Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review

Margutti, Karen Mello de Mattos; Schuch, Natielen Jacques; Schwanke, Carla Helena Augustin

doi:10.1590/1981-22562017020.160155

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…TNF-α, IL-6, CRP, albumin, WBC count and ESR were found to be associated with low physical performance, muscle strength or muscle mass in older people [8, 9, 13, 14, 16], but other studies failed to find this association [10, 11, 13, 17]. To date, TNF-α, IL-6, albumin and CRP have shown a relation with the development of low muscle strength or muscle mass over time [8, 13–15], however, the current body of evidence fails to reveal a marker of chronic inflammation that is univocally associated with measures of sarcopenia in older people [18, 19].…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

et al. 2019

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Background Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients. Methods Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia. Results A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = − 0.005; 95% CI = − 0.007, − 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = − 0.126; 95% CI = − 0.189, − 0.063) and lower relative skeletal muscle mass (β = − 0.179; 95% CI = − 0.274, − 0.084). Lower albumin levels were significantly associated with lower gait speed (β = − 0.020; 95% CI = − 0.011, − 0.028) and handgrip strength (β = − 0.596; 95% CI = − 0.311, − 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia. Conclusions In geriatric outpatients , erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia. Electronic supplementary material The online version of this article (10.1186/s12877-019-1253-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

et al. 2019

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“…In its systematic review study, Marguti et al stated that follistatin was only weakly correlated with the physical performance of the elderly. 16 The subgroup analysis of the sarcopenia and normal groups showed a significant negative relationship between waist circumference and follistatin levels. The greater the waist circumference, the lower the follistatin level in the elderly group who did not experience sarcopenia.…”

Section: Discussionmentioning

confidence: 94%

“…The results of this study are consistent with the results of a systematic review study by Marguti KM et al in 2017, which found that follistatin (and 4 other biomarkers) was not associated with sarcopenia. 16 The study by Choi K et al in 2020 also found that follistatin levels were not associated with the incidence of sarcopenia in patients with hepatocellular carcinoma (HCC). 17 Different results were obtained ultimately leading to hypertrophy and muscle growth.…”

Section: Discussionmentioning

confidence: 99%

The relationship between follistatin and sarcopenia in elderly

Aryana

Putrawan

Purnami

et al. 2022

IJBS

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Introduction: Sarcopenia is a multifactorial condition characterized by progressive and comprehensive mass loss accompanied by skeletal muscle strength or function. It can be triggered by physical inactivity, hormonal changes, energy, protein intake, oxidative stress and inflammatory processes. The state of inactivity underlying sarcopenia is related to follistatin levels. Methods: an analytical cross-sectional study conducted in Posyandu or Elderly Associations in Denpasar City with subjects aged ≥60 years old started from January 2021 to September 2021. The data collected were anthropometric measurements, muscle mass, grip strength, walking speed and serum follistatin levels. Sarcopenia was diagnosed based on the AWGS criteria. Bivariate analysis was performed using the Mann-Whitney analysis to determine the difference in the mean of the independent variables and the Spearman's test to determine the relationship between sarcopenia and follistatin levels. Results: 75 subjects were selected, and 15 (20%) subjects were diagnosed with sarcopenia. The results of the Spearman correlation test of upper arm circumference, waist circumference, calf circumference, SMI, walking speed, hand grip strength and follistatin levels only found a significant negative relationship between waist circumference and follistatin levels r= -0,309, p= 0,016. No differences in mean follistatin levels with sarcopenia and non-sarcopenia group p= 0,516. There was no significant relationship between follistatin levels and sarcopenia p= 0,615. Conclusion: There is no correlation between follistatin levels and sarcopenia in the elderly. However, follistatin is inversely correlated with waist circumference.

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“…Thus, there is an imbalance between fat mass and muscle mass that results in an inflammatory process due to changes in anabolic and catabolic mediators. With the reduction of concentrations of anabolic hormones such as testosterone, growth hormone (GH), insulin and IGF-1, catabolism is observed, which prevents muscle synthesis 30 .…”

Section: Discussionmentioning

confidence: 99%

Low muscle reserve in older adults and associated factors

Guerra

Fernandes

Silva

et al. 2022

Rev. bras. geriatr. gerontol.

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Objective To estimate the prevalence of low muscle reserve and identify associated factors in older people. Method Cross-sectional study carried out with 784 non-institutionalized older people (60 years or older), living in Viçosa, Minas Gerais, in 2009. The characteristics of interest were sociodemographic, life habits, health and anthropometric conditions. Low muscle reserve (LMR) was defined as leg circumference (LC) < 33 cm for women and < 34 cm for men. Descriptive analysis, bivariate and multiple analysis were performed, using Poisson regression with robust variance, to identify the factors independently associated with the outcome of interest. Results More than half of the sample consisted of women (52.9%), more frequently younger seniors (60 – 69 years old :49.5%), with a maximum of four years of study (79.9%). The prevalence of low muscle reserve was 21.7% (95%CI 18.9%-24.7%) and the independently associated factors were the age group from 70 to 79 years (PR:1.31; 95%CI: 0.96-1.795), 80 years or older (PR:1.64; 95%CI:1.12-2.70), history of hospitalization (PR: 1.46; 95%CI: 1.02-2.09) and low weight (PR: 5.45; 95%CI: 3.77-7.88). Conclusions The prevalence of LMR in the sample is expressive, it is related to older age, hospitalization and low weight. LC monitoring is important for tracking changes related to low muscle reserve in older people and associated factors should be considered in anthropometric assessments for this population.

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Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review

Cited by 9 publications

References 30 publications

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

The relationship between follistatin and sarcopenia in elderly

Low muscle reserve in older adults and associated factors

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