Abstrak Latar belakang: Sarkopenia adalah sindrom yang ditandai dengan penurunan massa otot disertai penurunan kekuatan otot dan atau fungsi otot. Stres oksidatif dan proses inflamasi dikenal sebagai faktor pemicu untuk sarkopenia dengan melepaskan rangsangan katabolik interleukin-6 (IL-6) dan protein C-reaktif (CRP). Penelitian ini bertujuan untuk menentukan hubungan antara IL-6 dan kadar CRP terhadap parameter sarkopenia seperti massa otot, kekuatan pegangan, dan kecepatan berjalan. Metode: Penelitian ini menggunakan desain cross-sectional analitik yang dilakukan di Desa Pedawa, Kabupaten Buleleng, Bali pada bulan Agustus 2016. Sekitar 79 responden berusia ≥ 60 tahun menggunakan teknik sampling acak stratifikasi. Variabel yang dinilai yaitu parameter sarkopenia (massa otot, kekuatan pegangan, dan kecepatan berjalan) termasuk IMT, serta IL-6 dan pemeriksaan tingkat CRP. Uji korelasi spearman dan parsial digunakan untuk menilai korelasi antara parameter IL-6, CRP, dan sarkopenia. Hasil: Kadar IL-6 dan CRP tidak berkorelasi signifikan dengan tiga parameter sarkopenia. Kadar CRP berkorelasi dengan IL-6 (r = 0.37; p = 0.001) dan IMT (r = 0.29; p = 0.009). Pada kelompok pria, IL-6 hanya berkorelasi dengan CRP (r = 0.40; p = 0.011). Sedangkan pada kelompok wanita, IL-6 berkolerasi dengan CRP (r = 0.38; p = 0.017), kecepatan berjalan (r = 0.33; p = 0.037) serta CRP berkorelasi dengan IMT (r = 0.32; p = 0.049) dan massa otot total (r = -0.32; p = 0.043). Setelah penyesuaian untuk variabel IMT, IL-6 berkorelasi dengan CRP (r = 0.43; p = 0,001) dan massa otot total (r = -0.25; p = 0.026) serta secara signifikan berkorelasi pada kelompok kurus (IMT<18.5 kg/m2) (r = -0.50; p = 0.026). CRP tidak berkorelasi secara signifikan dengan tiga parameter sarkopenia pada uji spearman, korelasi parsial, dan uji korelasi spesifik spearman berdasarkan pada kelompok IMT. Kesimpulan: Kadar IL-6 berhubungan dengan penurunan massa otot total pada keseluruhan lansia desa Pedawa setelah penyesuaian variabel IMT. Kata kunci: IL-6, Protein C-Reaktif (CRP), Sarkopenia, Lanjut usia, Desa Pedawa. Abstract Background: Sarcopenia is a syndrome characterized by decreased muscle mass with decreased muscle strength and or muscle function. Oxidative stress and inflammatory processes are known as triggering factors for sarcopenia by releasing catabolic stimuli of interleukin-6 (IL-6) and C-reactive protein (CRP).This study aims to determine the relationship between IL-6 and CRP levels to sarcopenia parameter such as muscle mass, grip strength, and walking speed. Methods: This study was an analytic cross-sectional design conducted at Pedawa Village, Buleleng District, Bali in August 2016. About 79 respondents aged ≥ 60 years using stratified random sampling technique. The assessed variables were sarcopenia parameter (muscle mass, grip strength, and walking speed) including BMI, as well as IL-6 and CRP levels examination. Spearman and partial correlation test were used to assess the correlation among IL-6, CRP, and sarcopenia parameters. Results: IL-6 levels and CRP were not significantly correlated with the three parameters of sarcopenia. CRP levels correlated with IL-6 (r = 0.37; p = 0.001) and BMI (r = 0.29; p = 0.009). In the male group, IL-6 was only correlated with CRP (r = 0.40; p = 0.011). While in the women group, IL-6 correlated with CRP (r = 0.38; p = 0.017), walking speed (r = 0.33; p = 0.037) and CRP correlated with BMI (r = 0.32; p = 0.049) and total muscle mass (r = -0.32; p = 0.043). After adjustment to BMI variable, IL-6 was correlated with CRP (r = 0,43; p = 0,001) and total muscle mass (r = -0.25; p = 0.026) and significantly correlated in underweight groups (BMI<18.5 kg/m2) (r=-0.50; p=0.026). CRP was not significantly correlated with the three parameters of sarcopenia on Spearman, partial correlation, and Spearman's specific correlation test based on BMI group. Conclusion: IL-6 levels were associated with total muscle mass loss after BMI adjustmentin Pedawa village’s elderly as a whole. Keywords: IL-6, C-Reactive Protein (CRP), Sarcopenia, Elderly, Pedawa village.
Background: Frailty as a result of decreased in age-related physiological systems that causes change in health status vulnerabilities that can be triggered by minor stressor events. One of the factors related to frailty is body mass index (BMI). Objective: We aimed to examine the correlation between BMI and frailty of elderly men in Pemecutan Village, West Denpasar District. Methods: A cross-sectional analytic study was conducted in Busung Yeh Kangin and Busung Yeh Kauh Banjar, Pemecutan Village, West Denpasar District. Data were collected after informed consent had been obtained through interview methods, grip strength, walking speed and anthropometric measurements. Interviews, anthropometry and frailty was assessed by Frailty Phenotype Fried. The Spearman correlation test was used to determine the bivariate relationship. Result: A total of 62 elderly men subjects with mean age of 69.26±7.11 years old. Frailty syndrome occurred in 50% subjects (n=32). There was no correlation between BMI and frailty in this study (r = 0.07; p = 0.5). Conclusion: There was no correlation between BMI and frailty in this study. This shows frailty is not related with poor BMI.
Background: Age, muscle strength, gait speed, functional activity have correlation to another, because if have decrease of result, it will increase risk to making geriatric syndrome including sarcopenia and frailty, and giving high risk morbidity and mortality elderly, based on that we will compare handgrip strength, gait speed and activity of daily living in elderly people in population in community with population in nursing home because of that has been little explored this problem. Objective: This study aimed to investigate the comparison handgrip strength, gait speed and activity of daily living between community and nursing home in population-based elderly. Methods: This is an observational analytic study, data we collect from cross sectional study in community and nursing home. Handgrip strength, gait speed and activity of daily living score were recorded to statistical program; p<0.05 was considered as statistically significant. Results: Sixty two geriatric sample from community and nursing home. We use Mann-Whitney method. There is significant difference of handgrip strength, gait speed and activity of daily living between elderly living in community and elderly living in nursing home. Handgrip strength (17.8+6.6 VS 14.2+6.1; P=0.008), gait speed (0.53 ± 0.187 VS 0.36 ± 0.07; P=0.000) and activity of daily living (19.1 ± 1.8 VS 12.1± 4.6; P=0.000) Conclusion: Our study showed decrease handgrip strength, gait speed and activity of daily living in nursing home versus community dwelling and this can make increase risk severe morbidity and mortality in elderly at Bali.
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