Entry of dengue virus serotypes and their geographic distribution in Brazilian federative units: a systematic review

Abstract

Objective: To describe the entry of Dengue virus (DENV) serotypes in Brazil and its federative units. Methods: A systematic review of studies published between 1980 and 2018 in databases and in the gray literature was performed using descriptors related to the years of entry of the DENV serotypes. Additionally, experts and official sources of information (Brazilian Ministry of Health) were consulted. Results: From 100 publications selected for the systematic review, 26 addressed the entry of DENV serotypes in the North region of the country, 33 in the Northeast, 24 in the Southeast, 14 in the Central-West, and five in the South. DENV-1 and DENV-4 were introduced in the North region in 1981. DENV-2 was introduced in the Southeast in 1990. DENV-3 was introduced in the North in 1999. Conclusion: The rapid expansion of dengue throughout the Brazilian territory was verified from the second half of the 1980s, with the gradual entry of the four serotypes, which resulted in the emergence of epidemics of arbovirus, which are currently verified in the country. Considering the epidemiology of the disease, more information should be disseminated and published in the wide-ranging scientific literature for a better understanding of the spread and circulation of DENV serotypes.

Acute kidney injury associated with dengue virus infection: a review

“…Dengue is a viral infection transmitted by arthropods, whose vector is the female mosquito of the genus Aedes, mainly Aedes aegypt 8 . This infection is caused by an RNA virus of the Flaviviridae family, which has different serotypes: DENV-1, DENV-2, DENV-3 and DENV-4 [9][10][11] . Recently, the existence of a fifth serotype (DENV-5) of isolates in Malaysia was postulated during an outbreak in 2007 12,13 .…”

Epidemiological profile of arboviruses in two different scenarios: dengue circulation vs. dengue, chikungunya and Zika co-circulation

“…Another factor potentially related to the fluctuation of dengue cases is the (re)introduction and/or predominance of different serotypes and/or viral genotypes [ 7 , 8 , 34 ]. The four DENV serotypes circulated in different Brazilian regions during 2011–2013 [ 10 , 35 , 36 ], however, to the best of our knowledge, there is no description of which serotypes circulated in Recife during this period. Despite this, it is important to consider that 2011 was the probable year of introduction of DENV-4 in Pernambuco state [ 10 ], which may have contributed to the cases of 2011 and 2012.…”

“…The four DENV serotypes circulated in different Brazilian regions during 2011–2013 [ 10 , 35 , 36 ], however, to the best of our knowledge, there is no description of which serotypes circulated in Recife during this period. Despite this, it is important to consider that 2011 was the probable year of introduction of DENV-4 in Pernambuco state [ 10 ], which may have contributed to the cases of 2011 and 2012. Unfortunately, the lack of surveillance on DENV serotypes (and/or genotypes) makes it difficult to discuss changes in dengue numbers from a herd immunity or ADE perspective.…”

“…The number of dengue cases and deaths is the result of a complex interaction among viral, host and environmental factors. The introduction of new serotypes and the antibody-dependent enhancement (ADE) phenomenon have been often associated with DENV infections and/or outbreaks [4][5][6][7][8][9][10]. Environmental factors, such as temperature, humidity and rainfall, which may influence the population of vector mosquitoes, also contribute to the increase in dengue numbers [11][12][13][14].…”

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

“…In the 1980s, there was an expansion of dengue throughout the Brazilian territory, with the gradual emergence of the four serotypes, which resulted in the emergence of arbovirus epidemics that are still observed in the country [58]. Regarding the epidemiological profile of dengue in Brazil between 2014 and 2019, dengue cases were predominant in the Southeast and Midwest regions, with a predominance of serotype 2 (DENV-2) [59].…”