Disparidades na mortalidade de câncer colorretal nos estados brasileiros

Oliveira, Max Moura de; Latorre, Maria do Rosário Dias de Oliveira; Tanaka, Luana Fiengo; Rossi, Benedito Mauro; Curado, María Paula

doi:10.1590/1980-549720180012

Cited by 29 publications

(30 citation statements)

References 27 publications

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“…In Brazil, CRC is the second most frequent type of cancer in women and the third most frequent in men (5). A recent study observed an increase in rate of mortality from CRC in Brazil, for both men and women when comparing data from 1996 to 2012 (6). These tumors accounted for 5.1% of all death by cancer in men in 1996 and for 6.9% in 2012; for women, the rates increased from 6.9% in 1996 to 8.2% in 2012 (6).…”

Section: Introductionmentioning

confidence: 99%

“…A recent study observed an increase in rate of mortality from CRC in Brazil, for both men and women when comparing data from 1996 to 2012 (6). These tumors accounted for 5.1% of all death by cancer in men in 1996 and for 6.9% in 2012; for women, the rates increased from 6.9% in 1996 to 8.2% in 2012 (6). Therefore, although the incidence of these tumors in Brazil remains lower than that of developed, high-income countries, mortality rates are similar, reflecting the disparity in the mortality–incidence ratio occurring in Brazil (7, 8).…”

Section: Introductionmentioning

confidence: 99%

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Microbiota Profile and Impact of Fusobacterium nucleatum in Colorectal Cancer Patients of Barretos Cancer Hospital

et al. 2019

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Microbial diversity has been pointed out as a major factor in the development and progression of colorectal cancer (CRC). We sought to explore the richness and abundance of the microbial community of a series of colorectal tumor samples treated at Barretos Cancer Hospital, Brazil, through 16S rRNA sequencing. The presence and the impact of Fusobacterium nucleatum ( Fn ) DNA in CRC prognosis was further evaluated by qPCR in a series of 152 CRC cases. An enrichment for potentially oncogenic bacteria in CRC was observed, with Fusobacterium being the most abundant genus in the tumor tissue. In the validation dataset, Fn was detected in 35/152 (23.0%) of fresh-frozen tumor samples and in 6/57 (10.5%) of paired normal adjacent tissue, with higher levels in the tumor ( p = 0.0033). Fn DNA in the tumor tissue was significantly associated with proximal tumors ( p = 0.001), higher depth of invasion ( p = 0.014), higher clinical stages ( p = 0.033), poor differentiation ( p = 0.011), MSI-positive status ( p < 0.0001), BRAF mutated tumors ( p < 0.0001), and the loss of expression of mismatch-repair proteins MLH1 ( p < 0.0001), MSH2 ( p = 0.003), and PMS2 ( p < 0.0001). Moreover, the presence of Fn DNA in CRC tissue was also associated with a worse patient cancer-specific survival (69.9 vs. 82.2% in 5 years; p = 0.028) and overall survival (63.5 vs. 76.5%; p = 0.037). Here we report, for the first time, the association of F. nucleatum presence with important clinical and molecular features in a Brazilian cohort of CRC patients. Tumor detection and classification based on the gut microbiome might provide a promising approach to improve the prediction of patient outcome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiota Profile and Impact of Fusobacterium nucleatum in Colorectal Cancer Patients of Barretos Cancer Hospital

et al. 2019

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“…Este achado corrobora com a literatura pertinente 15,16 . De acordo com o sexo e faixa etária, os óbitos por CCR em Sergipe e no Nordeste, seguiram o padrão da literatura onde as mulheres constantemente aparecem com taxas ligeiramente superiores às dos homens, e os idosos são responsáveis pelos maiores índices 10,[17][18][19][20][21] . De uma perspectiva ampla, fatores intrínsecos ao envelhecimento como aumento do estresse oxidativo e queda no desempenho do sistema imunológico estariam diretamente relacionadas a maiores índices na população idosa 22 .…”

Section: Discussionunclassified

“…Embora a maioria dos fatores de risco que se relacionam aos hábitos alimentares e culturais estarem concentrados nas regiões Sul e Sudeste, o Nordeste apresenta menor disponibilidade de serviços de saúde especializados, assim como piores taxas de escolaridade, que interferem no processo de diagnóstico precoce, tratamento adequado e, consequentemente na manutenção de índices crescentes de mortalidade 27,28 . Existe a possibilidade de um cenário real onde as taxas seriam ainda maiores, visto que, especialmente, no Nordeste, um estudo que avaliou taxas de mortalidade por CCR em um período de 16 anos, constatou o sub-registro dos óbitos e suas variáveis (no SIM e no DATASUS), e o grande número de óbitos por causas mal definidas, reverbera em menores números de óbitos por causas específicas, último grupo este que abrange a taxa de mortalidade por CCR 17 . A orientação e educação direcionada aos profissionais de saúde, desde o início da sua formação acadêmica, é de suma importância para que haja uma adequada notificação da real causa do óbito e que esses dados sejam alimentados no sistema DATASUS de modo fidedigno, o que irá auxiliar pesquisas e políticas preventivas.…”

Section: Discussionunclassified

Evolução comparativa e temporal das tendências de mortalidade por Câncer Colorretal em Sergipe e Nordeste no período de 2008 a 2018

Palmeira

Guimarães

Santos

et al. 2020

BJHR

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A incidência e as taxas de mortalidade por Câncer Colorretal (CCR) têm apresentado uma tendência mundial de crescimento. Objetivo: Analisar a evolução temporal e comparar as tendências de taxa de mortalidade por CCR no estado de Sergipe e no Nordeste brasileiro, no período de 2008 a 2018. Métodos: Estudo documental, de óbitos por CCR, no estado de Sergipe e na região Nordeste. Os dados foram coletados no Sistema de Informação em Mortalidade, do Departamento de Informática do Sistema Único de Saúde. A análise temporal foi realizada com aplicação do modelo de regressão por pontos de inflexão Joinpoint Regression Analysis. Resultados: Os óbitos por CCR em Sergipe e no Nordeste, foi predominante na região do cólon, seguido pelo reto e junção retossigmoide, prevaleceu nos idosos, com semelhança entre os sexos, porém ligeiramente maior nas mulheres. As taxas de mortalidade permaneceram crescentes entre 2008 e 2018, tanto em Sergipe como no Nordeste do Brasil. Em Sergipe, destacaram-se os seguintes pontos de inflexão (joinpoints), um aumento da mortalidade de 8,6% ao ano em mulheres e de 5,3% ao ano em homens, enquanto o Nordeste apresentou uma taxa de crescimento de 6,6% ao ano, para ambos os sexos. Conclusão: Necessita-se do fortalecimento e ampliação de medidas de promoção em saúde com ações preventivas, de diagnóstico precoce e de tratamento do CCR focadas no rastreamento da população, principalmente a mais idosa. A realização e manutenção dessas ações, a longo prazo, são comprovadamente capazes de impactar, positivamente na redução dos óbitos por essa afecção.

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“…In Brazil, CRC is the second most common cancer type for both women and men in the Southeast region (INCA, 2020). The new Brazilian mortalities rate of CRC showed an increase for both men and women when comparing data between 1996 and 2012 (Oliveira et al, 2018). A recent study by our group characterized the CRC in the Brazilian population, showing high prevalence in the APC (71.4%), TP53 (56.0%), KRAS (52.7%), PIK3CA (15.4%), and FBXW7 (10.9%) gene drivers, together with alterations in the MAPK/ERK, PIK3/AKT, NOTCH, and receptor tyrosine kinase signaling pathways (Dos Santos et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Pyknon-Containing Transcripts Are Downregulated in Colorectal Cancer Tumors, and Loss of PYK44 Is Associated With Worse Patient Outcome

et al. 2020

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Pyknons are specific human/primate-specific DNA motifs at least 16 nucleotides long that are repeated in blocks in intergenic and intronic regions of the genome and can be located in a new class of non-coding RNAs of variable length. Recent studies reported that pyknon deregulation could be involved in the carcinogenesis process, including colorectal cancer. We evaluated the expression profile of a set of 12 pyknons in a set of molecularly characterized colorectal cancer (CRC) patients. The pyknons ( PYK10 , PYK14 , PYK17 , PYK26 , PYK27 , PYK40 , PYK41 , PYK42 , PYK43 , PYK44 , PYK83 , and PYK90 ) expression was determined by qRT-PCR. A pilot analysis of 20 cases was performed, and consistent results were obtained for PYK10 , PYK17 , PYK42 , PYK44 , and PYK83 . Further, the expression of the selected pyknons was evaluated in 73 CRC cases. Moreover, in 52 patients, we compared the expression profile in both tumor and normal tissues. All five pyknons analyzed showed significantly lower expression levels in the tumor compared to normal tissue. It was observed an association between expression of PYK10 with TP53 mutations ( p = 0.029), PYK17 to histologic grade ( p = 0.035), and PYK44 to clinical staging ( p = 0.016). Moreover, levels of PYK44 were significantly associated with the patient's poor overall survival ( p = 0.04). We reported the significant downregulation of pyknons motifs in tumor tissue compared with the normal counterpart, and the association of lower PYK44 expression with worse patient outcome. Further studies are needed to extend and validate these findings and determine the clinical-pathological impact.

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Disparidades na mortalidade de câncer colorretal nos estados brasileiros

Cited by 29 publications

References 27 publications

Microbiota Profile and Impact of Fusobacterium nucleatum in Colorectal Cancer Patients of Barretos Cancer Hospital

Microbiota Profile and Impact of Fusobacterium nucleatum in Colorectal Cancer Patients of Barretos Cancer Hospital

Evolução comparativa e temporal das tendências de mortalidade por Câncer Colorretal em Sergipe e Nordeste no período de 2008 a 2018

Pyknon-Containing Transcripts Are Downregulated in Colorectal Cancer Tumors, and Loss of PYK44 Is Associated With Worse Patient Outcome

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