Aumento da carga de dengue no Brasil e unidades federadas, 2000 e 2015: análise do Global Burden of Disease Study 2015

Abstract

ABSTRACT:Objective: To describe the main metrics on dengue generated by Global Burden of Disease (GBD) Study 2015, for Brazil and its 27 federated units, in the years 2000 and 2015. Methods: The metrics described were: incidence and mortality rates by dengue, standardized by age, years of life lost (YLL), years lived with disability (YLD), and disability-adjusted life years (DALY) (in absolute frequency and age-standardized rates). The estimated metrics were presented with uncertainty intervals (UI 95%) for the years 2000 and 2015, accompanied by the relative percentages of changes. Results: The number of cases increased 232.7% and the number of deaths increased 639.0% between 2000 and 2015 in the country. The incidence rate varied 184.3% and the mortality rate was low, but with an increase of 500.0% in the period evaluated. The YLL, YLD, and DALY rates increased 420.0, 187.2, and 266.1%, respectively. In 2015, DALY was similar among women and men (21.9/100,000). The DALY increased more than double in all the Brazilian federated units. Conclusion:The marked increase in dengue over the years is associated with the introduction and/or circulation of one or more serotypes of the transmitter virus and an increasing proportion of patients affected by the severe form of the disease. Despite the low mortality rate of the disease in comparison between the years of study, the disease contributes to the loss of healthy years of life in Brazil as it affects a large number of people, from all age groups, causing some degree of disability during the infection and deaths, especially, in children.

Spatial and temporal distribution of dengue in Brazil, 1990 - 2017

“…In the period between 1990 and 2016, there was an increase in the incidence and consequent increase of dengue burden and the increase in the Disability-adjusted life-years (DALYs) of Neglected Tropical Diseases (NTDs).Dengue represented the third highest proportion of DALY in the period and the main cause among NTDs in 2016, with the highest absolute number of new cases in Brazil [27]. DALY increased more than double in all Brazilian states in the period from 2000 to 2015 [28]. The dengue lethality rate was relatively low [25,28].…”

“…DALY increased more than double in all Brazilian states in the period from 2000 to 2015 [28]. The dengue lethality rate was relatively low [25,28]. It should be borne in mind that dengue contributes to the loss of healthy life years due to its high incidence, affects all age groups and causes disability during symptomatic infection [28].…”

“…Despite the efforts and intensification of the control measures, there are critiques on the effectiveness of the PNCD [38] based on the increase in the last years of the number of severe cases, hospitalizations and deaths [27,28,35,39]. The incidence and mortality indices point to the need to improve the organization of response to dengue epidemics in an attempt to avoid severe cases, requiring an effort to mobilize managers and the population, with a permanent training program for health professionals, as well as intensification of intersectoral prevention and incentive actions for popular participation.…”

Distribution and breeding sites of Aedes aegypti and Aedes albopictus in 32 urban/peri-urban districts of Mozambique: implication for assessing the risk of arbovirus outbreaks

“…Dengue, chikungunya and Zika are among the most important mosquito-transmitted viruses worldwide. Their global burden of these diseases has increased rapidly in the last decades [ 1 , 2 ]. An estimated 390–500 million cases of dengue occur every year [ 1 , 3 ].…”

Dengue Fever and Aedes aegypti in indigenous Brazilians: seroprevalence, risk factors, knowledge and practices

“…Dengue remains an important public health problem in Brazil . In northeastern Brazil, the state of Ceará is characterised by the recurrent occurrence of epidemics since 1986 with an incidence of over 1000 cases/100 000 inhabitants and high mortality , isolation of the four dengue serotypes and cocirculation of the Chikungunya and Zika viruses since 2015 .…”