Prevalência de câncer colorretal associado ao papilomavírus humano: uma revisão sistemática com metanálise

Pelizzer, Thaisa; Dias, Caroline Pietá; Poeta, Júlia; Torriani, Tânia; Roncada, Cristian

doi:10.1590/1980-5497201600040009

Cited by 22 publications

(19 citation statements)

References 28 publications

(44 reference statements)

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“…However, it suggests that colonoscopy is the most effective screening method to prevent CRC deaths (34) . Also, despite of dietary factors evaluated in population attributable fraction (35) , there is a growing tendency to consider the association between human papillomavirus (HPV) and CRC (36) . Since it is one of the most common sexually transmitted diseases and the association with the incidence of this type of cancer, the importance of the early diagnosis of oncogenic HPV infection is now discussed for prevention of new cases.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Mortality for Colorectal Cancer in Brazil and Regions, by Sex, 1996-2015

Dutra

Parreira

Guimarães

2018

Arq. Gastroenterol.

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BACKGROUND: Colorectal cancer is among the three most frequent neoplasms in Brazil, being a public health problem. OBJECTIVE: To describe distribution pattern of colorectal cancer mortality in Brazil and regions, according to sex, between 1996 and 2015. METHODS: Values of standardized and stratified mortality rates by sex between 1996 and 2015 were used, through polynomial regression models and joinpoint analysis. RESULTS: It was observed that, for linear trends in mortality rates, for both sexes, there is a statistically significant trend increasing in both models, with rates and trends, and higher for men than for women, respectively, 7.3% per year (R2=0.95, P<0.001) and 6.5% per year (R2=0.87, P<0.001). It is observed a difference in magnitude and behavior of trend between the regions. CONCLUSION: It is understood that it is important to know the trend of rates in order to define priority populations for early interventions that increase survival and reduce mortality.

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Section: Discussionmentioning

confidence: 99%

Evolution of Mortality for Colorectal Cancer in Brazil and Regions, by Sex, 1996-2015

Dutra

Parreira

Guimarães

2018

Arq. Gastroenterol.

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“…Previous studies on HPV in CRC are conflicting (24). While some of them report HPV DNA in 31 −53% of CRC, others identified no HPV DNA (25, 26). Moreover, some Authors recognized transcriptional activity of the HPV E6/E7 oncogenes critical to HPV's role in carcinogenesis, while others not (27–29).…”

Section: Discussionmentioning

confidence: 99%

Putative Role of Circulating Human Papillomavirus DNA in the Development of Primary Squamous Cell Carcinoma of the Middle Rectum: A Case Report

et al. 2019

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Here we present the case of a patient affected by rectal squamous cell carcinoma in which we demonstrated the presence of Human Papillomavirus (HPV) by a variety of techniques. Collectively, the virus was detected not only in the tumor but also in some regional lymph nodes and in non-neoplastic mucosa of the upper tract of large bowel. By contrast, it was not identifiable in its common sites of entry, namely oral and ano-genital region. We also found HPV DNA in the plasma-derived exosome. Next, by in vitro studies, we confirmed the capability of HPV DNA-positive exosomes, isolated from the supernatant of a HPV DNA positive cell line (CaSki), to transfer its DNA to human colon cancer and normal cell lines. In the stroma nearby the tumor mass we were able to demonstrate the presence of virus DNA in the stromal compartment, supporting its potential to be transferred from epithelial cells to the stromal ones. Thus, this case report favors the notion that human papillomavirus DNA can be vehiculated by exosomes in the blood of neoplastic patients and that it can be transferred, at least in vitro , to normal and neoplastic cells. Furthermore, we showed the presence of viral DNA and RNA in pluripotent stem cells of non-tumor tissue, suggesting that after viral integration (as demonstrated by p16 and RNA in situ hybridization positivity), stem cells might have been activated into cancer stem cells inducing neoplastic transformation of normal tissue through the inactivation of p53, p21, and Rb. It is conceivable that the virus has elicited its oncogenic effect in this specific site and not elsewhere, despite its wide anatomical distribution in the patient, for a local condition of immune suppression, as demonstrated by the increase of T-regulatory (CD4/CD25/FOXP3 positive) and T-exhausted (CD8/PD-1positive) lymphocytes and the M2 polarization (high CD163/CD68 ratio) of macrophages in the neoplastic microenvironment. It is noteworthy that our findings depicted a static picture of a long-lasting dynamic process that might evolve in the development of tumors in other anatomical sites.

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“…Genotyping was performed by reverse hybridization using the INNO-LiPA HPV Genotyping Extra II Kit (Fujirebio Europe 1 ). The assay allows the identification of 32 HPV genotypes, currently known as high risk genotypes [16,18,31,33,35,39,45,51,52,56,58,59,68], probable high risk [26,53,66,70,73,82] and low risk [6,11,40,42,43,44,54,61,62,67,81,83,89].…”

Section: Plos Onementioning

confidence: 99%

“…There is a high discrepancy in the literature regarding the results of HPV prevalence in CRCs, ranging from 0 to 84.2% [39,[41][42][43][44]56]. Studies involving cases and controls show a higher frequency of the virus in the tumor tissue, but there are few investigations that use the non-tumor tissue adjacent to the tumor as a control (HPV prevalence ranging from 0% to 13.4%) [43,[57][58][59][60] as investigated in this study, or even other healthy colonic tissues (HPV prevalence ranging from 0% to 5.8%) [39,57].…”

Section: Plos Onementioning

confidence: 99%

“…The association of HPV with CRC has been investigated in several studies [39][40][41][42][43], however with controversial results. One of the main biases to prove such an association is the difficulty of studies demonstrating the presence of the virus in CRCs and precursor lesions, such as polyps and adenocarcinomas, and the absence of the virus in the adjacent normal tissue [41,43,44].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Human papillomavirus and the role of p16INK4a in colorectal carcinomas

et al. 2020

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Introduction Human papillomavirus (HPV) infection is associated with the development of anogenital and head and neck cancers. In recent years a potential role of HPV in colorectal cancer (CRC) has been suggested. Objective To investigate the presence of HPV in colorectal carcinomas and to study the role of p16 INK4a as a marker of transcriptionally active HPV infection. In addition, to investigate the correlation between these findings and the CRC prognostic factors. Methods Case control study with 92 cases of colorectal cancers, 75 controls of normal tissue adjacent to the tumor, and 30 controls of precursor lesions, including polyps and colorectal adenomas. Paraffinized samples were used, HPV detection and genotyping were performed by PCR and reverse hybridization by using the INNO LIPA kit, with SPF10 plus primers. The expression of the p16 INK4a protein was investigated using immunohistochemistry. Data analysis was performed using descriptive, univariate statistics and survival curves were calculated by using the Kaplan Meier and log-rank method. Results HPV was detected in 13% of the cases and the most prevalent genotype was HPV 16. HPV DNA was not detected in either control groups. The high expression of p16 INK4a was observed in 30% of the cases, but it was not associated to the presence of HPV. The overall survival was 53.3% and was influenced by prognostic factors such as later stage, lymph node and distant metastasis.

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Prevalência de câncer colorretal associado ao papilomavírus humano: uma revisão sistemática com metanálise

Cited by 22 publications

References 28 publications

Evolution of Mortality for Colorectal Cancer in Brazil and Regions, by Sex, 1996-2015

Evolution of Mortality for Colorectal Cancer in Brazil and Regions, by Sex, 1996-2015

Putative Role of Circulating Human Papillomavirus DNA in the Development of Primary Squamous Cell Carcinoma of the Middle Rectum: A Case Report

Detection of Human papillomavirus and the role of p16INK4a in colorectal carcinomas

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