Morphology, Crystalline Structure and Chemical Composition Of MAO Treated Ti-15Zr-Mo Surfaces Enriched with Bioactive Ions

Sousa, Tiago dos Santos Pereira de; Costa, Natália de Araujo da; Corrêa, Diego Rafael Nespeque; Rocha, L. A.; Grandini, Carlos Roberto

doi:10.1590/1980-5373-mr-2019-0005

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…Experiments have been carried out using 3D-printed titanium scaffolds in sheep and the results were found to be unsatisfactory in terms of bone ingrowth at 12 weeks (13). Studies have shown that the changing surface morphology and preparing bioactive coatings of the material can significantly impact the biocompatibility of 3D-printed porous titanium alloys (14,15). Therefore, it is crucial to modify the coated surface of 3D-printed porous titanium alloy scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Ni¹,

Jing²,

Xiong³

et al. 2022

Ann Transl Med

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Background: Three-dimensional (3D) printing technology has been widely used in orthopedics; however, it is still limited to the change of macroscopic structures. In order to further improve the biological properties of 3D-printed porous titanium scaffolds, this study introduced micro-arc oxidation (MAO) technology to modify the surface of porous titanium scaffolds and construct bioactive coatings on the surface of porous titanium scaffolds to improve the biocompatibility and osseointegration ability of the material.Methods: For in vitro experiments, human bone marrow stem cells (hBMSCs) were seeded onto untreated scaffolds (control group) and MAO-treated scaffolds (experimental group). After 24 h of co-culture, cytotoxicity was observed using live/dead staining, and cell/scaffold constructs were retrieved and processed for the assessment of cell morphology by using scanning electron microscopy (SEM). Cell proliferation was detected using the Cell Counting Kit-8 (CCK-8) assay after 3, 7, and 14 days of co-culture. The levels of alkaline phosphatase (ALP) in the cell supernatant were detected after 7 and 14 days of co-culture. For in vivo experiments, micro-computed tomography (micro-CT) and Masson Goldner's staining were used to evaluate bone ingrowth and osseointegration at 4 and 8 weeks postoperatively.Results: In vitro experiment results confirmed that the two groups of scaffolds were non-cytotoxic and the cell adhesion status on the MAO-treated scaffolds was better. Over time, cell proliferation and ALP levels were higher in the MAO-treated group than in the untreated scaffolds. In the in vivo experiments, the MAOtreated scaffolds showed better bone ingrowth and osseointegration than the untreated group at different time points. Conclusions:The MAO-treated porous titanium scaffold formed a uniform and dense bioactive coating on the surface, which was more conducive to cell adhesion, proliferation, and differentiation and showed better osseointegration and bone ingrowth in vivo.

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Section: Introductionmentioning

confidence: 99%

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Ni¹,

Jing²,

Xiong³

et al. 2022

Ann Transl Med

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“…Sousa et al developed alloys of the Ti-15Zr-Mo system (Mo = 0, 5, 10, and 15 wt%) and performed surface modification via MAO (300 V and 2.5 A) to functionalize the surface of the alloys with the elements calcium, phosphorus, and magnesium [ 19 ]. The XRD analysis showed that the formed ceramic layers have low crystallinity, and the crystalline phases are TiO 2 anatase and rutile, tetragonal zirconia, and CaCO 3 .…”

Section: Resultsmentioning

confidence: 99%

“…To carry out the surface modification process via MAO, an aqueous solution comprised calcium acetate monohydrate (C 4 H 6 CaO 4 H 2 0) of Reagen/Ultrapure Chemical of Brazil, β-glycerol phosphate (C 3 H 7 Na 2 O 6 P 5H 2 0) from Sigma-Aldrich (St. Louis, MO, USA) and magnesium acetate tetrahydrate (C 4 H 6 MgO 4 4H 2 O) from Sigma-Aldrich at a molar concentration of 0.35, 0.02, and 0.1 M, respectively [ 19 ]. The electrolyte was stirred for approximately four hours to ensure a good homogeneity of the solution.…”

Section: Methodsmentioning

confidence: 99%

Surface Characterization of New β Ti-25Ta-Zr-Nb Alloys Modified by Micro-Arc Oxidation

2023

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The technique of surface modification using electrolytic oxidation, called micro-arc oxidation (MAO), has been used in altering the surface properties of titanium alloys for biomedical purposes, enhancing their characteristics as an implant (biocompatibility, corrosion, and wear resistance). The layer formed by the micro-arc oxidation process induces the formation of ceramic oxides, which can improve the corrosion resistance of titanium alloys from the elements in the substrate, enabling the incorporation of bioactive components such as calcium, phosphorus, and magnesium. This study aims to modify the surfaces of Ti-25Ta-10Zr-15Nb (TTZN1) and Ti-25Ta-20Zr-30Nb (TTZN2) alloys via micro-arc oxidation incorporating Ca, P, and Mg elements. The chemical composition results indicated that the MAO treatment was effective in incorporating the elements Ca (9.5 ± 0.4 %atm), P (5.7 ± 0.1 %atm), and Mg (1.1 ± 0.1 %atm), as well as the oxidized layer formed by micropores that increases the surface roughness (1160 nm for the MAO layer of TTZN1, 585 nm for the substrate of TTZN1, 1428 nm for the MAO layer of TTZN2, and 661 nm for the substrate of TTZN2). Regarding the phases formed, the films are amorphous, with low crystallinity (4 and 25% for TTZN2 and TTZN1, respectively). Small amounts of anatase, zirconia, and calcium carbonate were detected in the Ti-25Ta-10Zr-15Nb alloy.

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Effect of heat treatment on the phases, pore size, roughness, wettability, hardness, adhesion, and wear of Ti-25Ta MAO coatings for use as biomaterials

Kuroda,

de Mattos,

Grandini

et al. 2023

J Mater Sci

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Morphology, Crystalline Structure and Chemical Composition Of MAO Treated Ti-15Zr-Mo Surfaces Enriched with Bioactive Ions

Cited by 11 publications

References 29 publications

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Surface Characterization of New β Ti-25Ta-Zr-Nb Alloys Modified by Micro-Arc Oxidation

Effect of heat treatment on the phases, pore size, roughness, wettability, hardness, adhesion, and wear of Ti-25Ta MAO coatings for use as biomaterials

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