New tendencies in non-surgical periodontal therapy

Haas, Alex Nogueira; Furlaneto, Flávia Aparecida Chaves; Gaio, Eduardo José; Gomes, Sabrina Carvalho; Palioto, Daniela Bazan; Castilho, Rogerio M.; Sanz, Mariano; Messora, Michel Reis

doi:10.1590/1807-3107bor-2021.vol35.0095

Cited by 25 publications

(26 citation statements)

References 167 publications

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“…Non-surgical periodontal therapy (NSPT) is the treatment of choice as phase 1 in cases of periodontitis, as recommended by EFP S3 level clinical practice guidelines [ 23 ]. Its primary aim is to reduce the overall microbial burden and reduce inflammation of periodontal tissues; however, many published randomized controlled investigations have also shown an improvement of oxidative stress parameters and/or antioxidative status with or without a particular adjuvant [ 34 , 35 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…The hyaluronic acid (HA) adjunctive treatment study group ( n = 50) received non-surgical periodontal therapy, including subgingival instrumentation, followed by HA application to the existing pockets, while the control group ( n = 50) received only non-surgical periodontal therapy without HA application [ 23 ]. The non-surgical one-session instrumentation (full mouth debridement) for both groups was applied at the baseline and after six weeks.…”

Section: Methodsmentioning

confidence: 99%

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The Influence of Hyaluronic Acid Adjunctive Therapy of Periodontitis on Salivary Markers of Oxidative Stress: Randomized, Controlled Clinical Trial

et al. 2022

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Periodontitis is a common oral disease affecting the tooth-supporting tissues. Bacteria have been long viewed as the main causative factor in its development; however, many investigations have proved that aberrant immune and inflammatory response and the resulting misbalance between the damage caused by reactive oxygen species and the antioxidant capacity of tissues may be an underlying factor in disease progression that reduces healing potential. The objective of the current trial is to assess the outcomes of the addition of hyaluronic acid (HA) to standard non-surgical periodontal therapy (NST) on some major oxidative stress markers in saliva. HA-based gel designed for dental application was used and the measurements were taken after 3 months. HA adjunctive therapy had a significantly greater increase in markers with antioxidant properties as well as total antioxidant capacity compared to standard NST alone. Furthermore, clinically measured levels of gingival inflammation (bleeding on probing-BOP) and periodontal destruction (clinical attachment loss-CAL) were significantly correlated with these markers, and the correlation was negative. This investigation demonstrates that HA may indeed express antioxidant properties and improve the antioxidant capacity of periodontal tissues, thus improving the prognosis for the teeth and the results of periodontal therapy. Further investigations will be necessary to determine the duration of these effects over time.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Influence of Hyaluronic Acid Adjunctive Therapy of Periodontitis on Salivary Markers of Oxidative Stress: Randomized, Controlled Clinical Trial

et al. 2022

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“…Periodontal therapy aims to reduce infection and inflammation, applying a more comprehensive range of interventions in a gradual and steady process [8]. The first step marks the control of supragingival biofilm by the patient and the professional, as well as those recognized risk factors in the aetiopathogenesis of periodontal conditions [9,10]. In periodontitis patients, the first step is a prerequisite before applying the second step, based on the elimination of subgingival biofilm and calculus, which is the basic method of periodontal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…This could be due to microbial factors which are unable to convert the imbalanced infectious process to a more homeostatic/commensal balance, possibly due to subgingival biofilm remnants in the periodontal pocket after SRP [14], and/or tissue influx by periodontopathic bacteria [15] or the preservation of a due inflammatory process despite subgingival debridement. Therefore, there is a continuous search for adjunctive therapies that can improve the outcomes of subgingival instrumentation while considering the patients' health, potential adverse effects, availability, and cost [10,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies

Al‐Shibani¹

2022

Cureus

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This systematic review aimed to assess scientific data of existing literature to identify the efficacy of resolvins (Rv) in the treatment of periodontitis. The electronic databases, Web of Science (WOS), Medline/PubMed, The Cochrane Library, Scopus, and Saudi digital library (SDL), were searched for eligible studies in the field of periodontics. A thorough analysis of the retrieved literature provided five articles that were assessed and included in this systematic review. The quality of these studies was assessed by updated Essential Animal Research: Reporting of In-Vivo Experiments (ARRIVE) guidelines. The five included studies were published between 2005 and 2018 and investigated resolvins as a treatment approach in experimental periodontitis of animals. Among the study animals employed, New Zealand white rabbits were used in three studies, Wistar rats and Albino mice in two studies, respectively. Four studies have evaluated eicosapentaenoic acid-derived RvE1, and one study evaluated docosahexaenoic acid-derived RvD2. Oraltopical application of Rv was followed in four studies, and intra-peritoneal Rv injection was administered in one study. The study duration in these studies have ranged between 4-12 weeks, and the Rv dose was between 0.1 μg to 0.5 μg. One study evaluated the influence of RvE1 topical application on both the prevention and treatment of experimental periodontitis. Resolvins (RvE1 and RvD2) have been studied in periodontitis-induced animal models to assess their potential role in periodontal inflammation resolution. There are promising preclinical data of using resolvins as a treatment modality in experimental periodontitis. Resolvins have been demonstrated to inhibit the destructive inflammatory process and alveolar bone loss in laboratory-induced periodontitis under controlled experimental conditions.

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“…In addition to vitamin D and calcium, multiple newer non-surgical modalities for periodontal disease have been investigated. These non-surgical modalities include probiotics, prebiotics/synbiotics, statins, pro-resolving mediators, omega-6 and -3 therapy, ozone therapy, and epigenetic therapy [ 17 ], as well as photodynamic therapy (specifically as an adjunct therapy) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium and Vitamin D Supplementation as Non-Surgical Treatment for Periodontal Disease with a Focus on Female Patients: Literature Review

Dalipi

Dragidella

2022

Dentistry Journal

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Periodontal disease is a complex disease that involves an imbalance between the oral microbiota and an individual’s inflammatory response. Moreover, the inflammatory response contributes to further imbalance; if left untreated, periodontal disease may result in tooth loss. Vitamin D is intricately involved in the regulation of calcium–phosphate homeostasis and bone mineral metabolism; considering that periodontal surgery usually includes regenerative therapy, adequate vitamin D and calcium levels are essential. The benefits of vitamin D and calcium supplementation have been demonstrated in situations where deficiency is associated with adverse outcomes, such as periodontal disease and maternal health. However, knowledge and attitudes about supplementation, as well as the actual levels of supplementation, vary greatly in the general population; they also differ between men and women. The aim of this review is to discuss how vitamin D and calcium supplementation affect oral and periodontal health, especially in women. Additionally, this review provides suggestions for public health strategies regarding vitamin D and calcium supplementation, as well as the effects of both types of supplementation on maternal oral health.

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New tendencies in non-surgical periodontal therapy

Cited by 25 publications

References 167 publications

The Influence of Hyaluronic Acid Adjunctive Therapy of Periodontitis on Salivary Markers of Oxidative Stress: Randomized, Controlled Clinical Trial

The Influence of Hyaluronic Acid Adjunctive Therapy of Periodontitis on Salivary Markers of Oxidative Stress: Randomized, Controlled Clinical Trial

Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies

Calcium and Vitamin D Supplementation as Non-Surgical Treatment for Periodontal Disease with a Focus on Female Patients: Literature Review

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