Cytotoxicity, and antimicrobial and physicochemical properties of sealers incorporated with Uncaria tomentosa

Caldas, Nathália Lima; Prado, Marina Carvalho; Carvalho, Nancy Kudsi; Senna, Plínio Mendes; Silva, Emmanuel João Nogueira Leal

doi:10.1590/1807-3107bor-2021.vol35.0086

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…A total of 13 articles were included in the scoping review: three studies for the primary outcome—studies describing a possible application of the tomentose claw extracts in endodontics: Herrera et al, 2016 [ 24 ], Herrera et al, 2010 [ 25 ], Caldas et al, 2021 [ 22 ]; 10 studies for the secondary outcome—studies that concerned the possible application of Uncaria tomentosa in medicine and oral pathology: Tay et al, 2015 [ 26 ], Tay et al, 2014 [ 21 ], Paiva et al, 2009 [ 27 ], Silva et al, 2021 [ 28 ], Vergiú 2006 [ 29 ], Caldas et al, 2010 [ 30 ]. …”

Section: Resultsmentioning

confidence: 99%

“…three studies for the primary outcome—studies describing a possible application of the tomentose claw extracts in endodontics: Herrera et al, 2016 [ 24 ], Herrera et al, 2010 [ 25 ], Caldas et al, 2021 [ 22 ];…”

Section: Resultsmentioning

confidence: 99%

“…Caldas et al, 2021 [ 22 ] instead reported that the bacterial load is further reduced when MTA and AH plus are mixed with herbal remedies derived from UT. These three in vitro microbiological studies, in association with the salivary cultural data of 100 patients reported in the study by Ccahuana-Vasquez et al, 2007 [ 20 ], suggest an antibacterial action that UT directs towards many bacteria involved in the persistence of endodontic lesions ( E. faecalis ), although the data of Vasquez et al do not show an inhibitory action for C. albicans and P. aeruginosa in the culture.…”

Section: Discussionmentioning

confidence: 99%

“…The data presented in the literature certainly demonstrate antibacterial and antifungal activity due to the presence of bioactive principles; it is also worth noting the anti-inflammatory capacity. These characteristics make UT extracts a suitable candidate in applications in endodontic use, because the antimicrobial activity demonstrated against Enterocccus faecalis is also expressed after the application of the endodontic gel, since the compound is partially adsorbed by the dentinal surface, and the antimicrobial effect is also expressed when the compound is present in formulations with other endodontic cements [ 22 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Applications in the dental field have been described both in the prevention and treatment of stomatitis and as an antibacterial [ 20 ] and anti-inflammatory [ 21 ] agent; it has also been investigated as an additive in irrigants, and specifically as gels and in endodontic cements, to exploit the ability of the active ingredients to be adsorbed by the tooth surface with a mechanism similar to CHX and to be released [ 22 ], successively slowly exerting its inhibitory action on bacterial proliferation.…”

Section: Introductionmentioning

confidence: 99%

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Application of the Extracts of Uncaria tomentosa in Endodontics and Oral Medicine: Scoping Review

Dioguardi

Spirito

Sovereto

et al. 2022

JCM

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Background: The main purpose of endodontic treatment is to eliminate the bacteria that are responsible for the contamination and infection of the internal surfaces in order to resolve any pulp or periapical pathology. In fact, some bacteria, such as Enterococcus faecalis, can escape the action of root canal irrigants by aggregating into a biofilm and penetrating deeply into the dentinal tubules. Uncaria tomentosa is a plant belonging to the Rubiaceae family and also commonly known as cat’s claw due to the shape and position of the spines; it is a traditional Peruvian medicinal plant of Amazonian origin. Applications in the dental field have been described both in the prevention and treatment of stomatitis and as an antibacterial and anti-inflammatory agent; it has also been investigated as an additive in irrigants and specifically as gels in endodontic cements. The aim of this scoping review is to summarize all the scientific evidence on the possible applications of Uncaria tomentosa extracts in endodontics and, more generally, in oral medicine, in order to understand whether the active ingredients extracted from Uncaria tomentosa can bring a real advantage in endodontics, in the reduction of endodontic failures and in the onset of recurrent endodontic lesions. Methods: The scoping review was carried out strictly following the PRISMA-ScR checklist; the search was carried out on five databases (PubMed, Scopus, Science Direct, EBSCO and Web of Science) and a register (Cochrane library). Results: The research produced a number of bibliographic sources totaling 2104. With the removal of duplicates, 670 were obtained; potentially eligible articles amounted to 23, of which only seven in vitro studies (four microbiological studies), five clinical studies (three randomized trials) and a case report were included. Conclusions: From the data in the literature, it can be stated that the active ingredients present in Uncaria tomentosa could represent an interesting product to be used in the endodontic field, both in endocanalary cements and as a gel.

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