Potential link between SARS-CoV-2 and Kawasaki disease: importance of dentists for the diagnosis

Martelli, Hercílio; Machado, Renato Assis; Martelli, Daniella Reis Barbosa; Barbosa, Mauro Costa; Bonan, Paulo Rogério Ferreti; Coletta, Ricardo D.

doi:10.1590/1807-3107bor-2021.vol35.0047

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This mechanism could also be the basis of early manifestations of COVID-19, such as taste alteration and xerostomia [ 95 ]. The immune response to infection could activate Langerhans cells and lymphocytes, leading to vasculitis and thrombocytopenia, causing oral lesions related to vascular disorders (e.g., petechiae) [ 19 , 41 , 92 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review

Orilisi

Mascitti

Togni

et al. 2021

IJERPH

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Background: COVID-19 disease first appeared in 2019 and quickly spread worldwide, causing a global pandemic. The oral cavity represents a target of SARS-CoV-2, and oral lesions are observed in both non-hospitalized and hospitalized patients. This systematic review aims to investigate the frequency of oral manifestations in COVID-19 hospitalized patients. Methods: An electronic search was conducted in PubMed, Scopus, and Web of Science databases, including articles published up to September 2021. The review protocol was based on PRISMA-P. The risk of bias of the studies was assessed using the Joana Briggs Institute. The certainty of evidence was assessed using the GRADE instrument. Results: Fifty-nine articles were included: 19 case reports, 17 case series, 2 case-control studies, 13 cross-sectional studies, 4 observational studies, and 4 retrospective studies. Oral ulcers, cheilitis, and tongue lesions were more common in patients before hospitalization, while perioral pressure ulcers, macroglossia, blisters, and oral candidiasis were more recurrent in patients during hospitalization. The first could be related directly to COVID-19, while the latter could be caused by medical devices, treatments, prone position, and immunological impairment. Conclusions: An accurate oral examination during the hospital admission of all confirmed COVID-19 cases is encouraged to recognize oral early manifestations and to apply appropriate treatments.

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Section: Discussionmentioning

confidence: 99%

Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review

Orilisi

Mascitti

Togni

et al. 2021

IJERPH

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“…After titles and abstracts screening, 37 studies remained. Reading these study texts resulted in exclusion of 19 more studies due to: (3) study design as letter to the editor, 3,11,12 (5) review article, [13][14][15][16][17] (8) because they did not evaluate or report or have the oral manifestations, 18,19 (2) due to patients being older than 18-year-old, 20,21 and (1) the patients had underlying diseases. 22 A manual search for articles identified eight more studies.…”

Section: Resultsmentioning

confidence: 99%

Oral manifestations of multisystemic inflammatory syndrome in children (MIS‐C) and Kawasaki disease associated to COVID‐19: A systematic review

Nascimento

Araujo

Silva

et al. 2021

Special Care in Dentistry

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Aims: Multisystemic inflammatory syndrome in children (MIS-C) is a condition noted in some children asymptomatic but positive to Sars-cov-2 antibody and it presents clinical and laboratory changes similar to Kawasaki disease (KD). Oral changes have also been observed. This systematic review evaluated oral manifestations detected in children with MIS-C and KD associated to COVID-19. Methods and Results: This work was registered at PROSPERO (#CRD42020225909), following PRISMA guidelines. A comprehensive research was conducted in MEDLINE, Web of Science, EMBASE, LILACS, Scopus, and Grey Literature through August 2021, based on original research evaluating children diagnosed with MIS-C or KD related to COVID-19. Two authors independently screened all retrieved references. Twenty five selected studies evaluated 624 children, mean age 8.78 years. The assessment of the risk of bias (ROB) showed that most of them presented low ROB. Oral manifestations were erythematous mucous membrane, oral ulcers lesions, dry, swollen and cracked lips, and strawberry tongue. Conclusion: MIS-C and KD share the same oral manifestations and their identification may lead to an early diagnosis.

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