Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

Costa, Tereza Karla Vieira Lopes da; Barros, Mariana Silva; Braga, Renan Marrinho; Viana, Jéssika de Oliveira; Sousa, Frederico Barbosa de; Scotti, Luciana; Batista, André Ulisses Dantas; Almeida, Reinaldo Nóbrega de

doi:10.1590/1807-3107bor-2020.vol34.0094

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Even so, the combination of the two compounds (S)-(-) citronellal + MK was able to almost completely inhibit the nociceptive effect generated by glutamate, demonstrating that a synergistic action of effects may occur, thus signaling a possible mechanism of (S) )-(-) citronellal on a receptor other than glutamatergic NMDA. Some previous studies have shown similar effects for citronellal and other monoterpenes, as well as computational docking studies indicate glutamate receptors as possible targets for citronellal and monoterpenes in general, showing that more specific studies are needed to determine the real interference of citronellal monoterpene in these receptors (Assis et al, 2020;Santos et al, 2016, Costa et al, 2020Quintans-Junior et al, 2010).…”

Section: Discussionmentioning

confidence: 78%

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

et al. 2023

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Due to the complex nature of pain and the participation of physical, cognitive, psychological and behavioral aspects, pain management has several approaches. The use of medicinal plants in developing countries is quite expressive. Seeking new options for the treatment of emerging or debilitating diseases. Therefore, the present study seeks to elucidate the effects of the monoterpene, citronellal, differentiating its activity by isomers (R)-(+) and (S)-(-) citronellal. The study used several methods to evaluate the effects of citronellal isomers on motor coordination, nociceptive response, and the involvement of opioid, glutamatergic, and transient receptor pathways. The methods included rota-rod, hot-plate, and formalin tests, as well as the use of specific inhibitors and agonists. Data were analyzed using inferential statistics with a 95% confidence level. Both isomers did not significantly affect the motor coordination of the studied animals. The isomer (S)-(-) citronellal showed better results in relation to its structural counterpart, managing to have an antinociceptive effect in the formalin and hot plate tests with a lower concentration (100 mg/kg) and presenting fewer side effects, however, the this study was not able to elucidate the mechanism of action of this isomer despite having activity in studies with substances that act on specific targets such as glutamate and capsaicin, its activity was not reversed with the use of antagonists for pathways related to nociception. While the (R)-(+) citronellal isomer, despite showing total activity only at a concentration of 150 mg/kg, was able to determine its mechanism of action related to the opioid pathway by reversing its activity by the antagonist naloxone, being this is a pathway already correlated with nociception control treatments, however, it is also related to some unwanted side effects. In this way, new studies are sought to elucidate the mechanism related to the isomer (S)-(-) citronellal and a possibility of use in other areas related to the treatment of pain or inflammation.

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Section: Discussionmentioning

confidence: 78%

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

et al. 2023

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“…These results corroborate the effect observed in the writhing and formalin tests, suggesting that Es and Es/β-CD have centrally-acting antinociceptive activity. Recent previous studies have demonstrated the antinociceptive activity of monoterpenes, including 1,8-cineole [ 28 ] and geraniol [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its β-Cyclodextrin Inclusion Complex in Animal Models

Costa

Martins

Pessoa

et al. 2022

Plants

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(1) Background: estragole is a monoterpene found in the essential oils of several aromatic plants, which can be used for several pharmacological activities. The aim of this study was to evaluate the antinociceptive effect of estragole (Es) and its β-cyclodextrins inclusion complex (Es/β-CD). (2) Methods: the effects of Es and Es/β-CD on the central nervous system (CNS) were evaluated through open field and rota-rod assays, and the antinociceptive effect in formalin models, abdominal writhing induced by acetic acid, hot plate, tail flick test and plantar mechanical hyperalgesia. (3) Results: Es and Es/β-CD showed no alterations on the CNS evaluated parameters and the results suggested there was an antinociceptive action in the formalin, abdominal writhing, hot plate, tail flick tests and plantar mechanical hyperalgesia, proposing the involvement of the nitric oxide, glutamatergic signaling pathways, cyclic guanosine monophosphate and vanilloid pathways. (4) Conclusion: the results suggest that Es and Es/β-CD have a promising antinociceptive potential as a possible alternative for the pharmacological treatment of pain, also showing that the encapsulation of Es in β-cyclodextrins probably improves its pharmacological properties, since the complexation process involves much lower amounts of the compound, contributing to better bioavailability and a lower probability of adverse effect development.

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Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis

Rodriguez

Ouyang²,

Kandasamy³

2021

Behavioural Pharmacology

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Cannabis has been used for centuries for its medicinal properties. Given the dangerous and unpleasant side effects of existing analgesics, the chemical constituents of Cannabis have garnered significant interest for their antinociceptive, anti-inflammatory and neuroprotective effects. To date, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) remain the two most widely studied constituents of Cannabis in animals. These studies have led to formulations of THC and CBD for human use; however, chronic pain patients also use different strains of Cannabis (sativa, indica and ruderalis) to alleviate their pain. These strains contain major cannabinoids, such as THC and CBD, but they also contain a wide variety of cannabinoid and noncannabinoid constituents. Although the analgesic effects of Cannabis are attributed to major cannabinoids, evidence indicates other constituents such as minor cannabinoids, terpenes and flavonoids also produce antinociception against animal models of acute, inflammatory, neuropathic, muscle and orofacial pain. In some cases, these constituents produce antinociception that is equivalent or greater compared to that produced by traditional analgesics. Thus, a better understanding of the extent to which these constituents produce antinociception alone in animals is necessary. The purposes of this review are to (1) introduce the different minor cannabinoids, terpenes, and flavonoids found in Cannabis and (2) discuss evidence of their antinociceptive properties in animals.

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Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

Cited by 5 publications

References 32 publications

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers

Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its β-Cyclodextrin Inclusion Complex in Animal Models

Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis

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