Peri-implantitis as a “burden” disease

Abstract

Peri-implantitis as a "burden" disease The use of dental implants to restore partially and totally edentulous subjects is a successful treatment in Contemporary Dentistry. Overall, the global market of dental implants was valued at US$ 2,91 billion in 2016 with more than 8.809 million implants placed. 1 However, the prevalence of biological complications regarding dental implant supported restorations is growing in the same rate. A plethora of studies showed a main concern about this scenario, wherein the prevalence of peri-implant diseases ranged between 0.4 to 43% after 5 years. 2 The number of studies about peri-implantitis also raise in the same proportion in the last 30 years according PubMed (Figure), from 86 papers in the 90s' to a total of 1938 manuscripts until now.

Current Concepts on the Pathogenesis of Peri-implantitis: A Narrative Review

“…An acute inflammatory response is elicited at the moment after implant installation. 10 Complement activation plays a crucial role in the immune response cascade by identifying a foreign body’s presence and regulating macrophages monocytes’ chemotaxis and bone cells. 49 Macrophages also play a significant role in the foreign body response.…”

“…9 Peri-implantitis has currently become a substantial economic burden since implant therapy was estimated at the cost of US $2.91 billion in 2016. 10 Moreover, the number of studies regarding peri-implantitis in PubMed has risen in the past years from 86 articles in the 1990s to a total of 1,938 articles until 2018. 10 The consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions concluded that peri-implantitis is an inflammatory process of a microbial origin that causes bone loss.…”

“…10 Moreover, the number of studies regarding peri-implantitis in PubMed has risen in the past years from 86 articles in the 1990s to a total of 1,938 articles until 2018. 10 The consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions concluded that peri-implantitis is an inflammatory process of a microbial origin that causes bone loss. 3 In addition, several risk factors have been proposed as potential codrivers in this entity, including history of periodontitis and poor plaque control.…”

“… 9 Peri-implantitis has currently become a substantial economic burden since implant therapy was estimated at the cost of US $2.91 billion in 2016. 10 Moreover, the number of studies regarding peri-implantitis in PubMed has risen in the past years from 86 articles in the 1990s to a total of 1,938 articles until 2018. 10 …”

“… 10 Moreover, the number of studies regarding peri-implantitis in PubMed has risen in the past years from 86 articles in the 1990s to a total of 1,938 articles until 2018. 10 …”