Squamous cell carcinoma of the tongue in patients older than 45 years

Abstract

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Complete data from 60 cases were evaluated. They were more common in males (mean age = 63.9 years). Unexpectedly a high rate of tumors (38.3%) were in the base of the tongue (BT). Moderately and poorly differentiated SCCT were the most common. 16.7% presented lymph node invasion, 15% were recurrent tumors and BT carcinomas recurred more frequently. A high rate (81.7%) were stage II and 48.3% were low-risk patients. SCCTs in the studied population displayed different clinico-pathological and behavioral features compared with worldwide data. Our results suggest that BT tumors should be treated more aggressively than those in the mobile tongue. BT located tumors were more frequent than previously published. Additional frequency studies will define outcomes in age cohorts with a consensus cutoff for young and elderly populations. More population-based studies should be performed in Latin American regions to acquire accurate data on SCC incidence in elder subpopulations and to identify precisely the etiological factors in these patients.

Squamous Cell Carcinoma of Tongue: Analysis of Clinico Pathological Features

“…The predominant T stage in the present study is found to be T3 (44.4 %) while least common is found to be T1 (18.5 %). A study conducted in Mexico, reported T2 as common size of tumor found in their study (78.3%) [25]. These findings suggests that majority of patients seek medical help when size of lesion is already large or when it starts to disturb them.…”

Cell cycle markers and apoptotic proteins in oral tongue squamous cell carcinoma in young and elderly patients

“…A matter of controversy surrounds the ranges established for classification of young age (≤ 30 years 8 to ≤ 60 years 20 ), although OTSCC is more commonly observed at the ages of ≤ 40 years 2,10 and ≤ 45 years. 6,14,17 This lack of consensus hinders comparison with different studies. In the present study, patients aged ≤ 45 years were classified as young because this is the cutoff already established by our research group.…”

“…The cutoff age of 45 years was used following previously published recommendations. 5,6,11,14,17 Patients previously subjected to radiation therapy or chemotherapy were excluded. This study was approved by the Research Ethics Committee of Universidade Estadual da Paraíba (process no.…”

“…In recent years, there has been an increase in the overall incidence of oral tongue squamous cell carcinoma (OTSCC) in young patients 1,2,3 at a frequency that ranges from 0.13 to 12.76% among all cases of OTSCC. 2,3,4,5,6 Males are more frequently affected by OTSCC, regardless of age, although recent studies have indicated an increase in incidence among young women. 1,3 The etiopathogenesis of OTSCC in young patients is still widely discussed in the scientific literature because many patients are not exposed to the main risk factors, such as smoking and/or alcohol consumption.…”

Análise clínico-patológica de carcinoma epidermóide em assoalho bucal: Relato de caso

“…O sexo masculino apresenta uma maior predisposição para esse tipo de carcinoma, cuja aparição ainda pode estar associada, entre outros fatores, ao HPV, decorrente da infecção através do sexo oral (Ledesma-Montes et al, 2018). Esse tumor caracteriza-se por um comportamento biológico variável e é com frequência encontrado nas glândulas salivares maiores, especialmente na parótida.…”