Clinicopathological analysis of salivary gland tumors over a 15-year period

Abstract

Clinicopathological analysis of salivary gland tumors over a 15-year period Abstract: Salivary gland tumors (SGT) are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group as well as anatomic location, histological type and clinical behavior of the tumor were recorded. Availability of complete information about these aspects was considered the inclusion criteria. Descriptive statistical analysis of the data was performed using the frequencies of categorical variables. Among the 2168 cases of tumors in the head and neck region, 243 (11.20%) cases were diagnosed in the salivary glands, 109 of which met the inclusion criteria: 85 (78%) benign tumors and 24 (22%) malignant tumors. Mean patient age was 46.47 years. The female gender accounted for 56 cases (51.4%) and the male gender accounted for 53 (48.3%). The major salivary glands were affected more (75.2%) than the minor glands. The most frequent benign and malignant SGTs were pleomorphic adenoma (81.2%) and adenoid cystic carcinoma (58.3%), respectively. In conclusion, pleomorphic adenoma and adenoid cystic carcinoma are the most frequent benign and malignant lesions, respectively. Comparing the present data with previous studies on SGTs, one may infer that some demographic characteristics and the predominance of malignant tumors vary in different geographic regions.

Perfil epidemiológico de neoplasias epiteliales de glándulas salivales

“…Por otro lado, las neoplasias malignas correspondieron a 19,5% de los casos registrados, resultado similar a series de Brasil 10,14 , pero que difieren a otros estudios a nivel mundial donde se reportan frecuencias entre 32-38% (Tabla 4). Lo anterior podría sugerir una variación geográfica en la frecuencia de las neoplasias malignas de glándulas salivales, así como variaciones locales en las modalidades de estudio diagnóstico y criterios de indicación quirúrgica, reduciendo el número de paciente operados por neoplasias benignas y afectando directamente a las frecuencias reportadas.…”

“…De acuerdo a la localización, las neoplasias de glándulas salivales fueron más frecuentes en glándula parótida (82,8%), seguido por la glándula submandibular (12,9%) y luego por las glándulas salivales menores (4,2%), lo cual es similar a varios resultados reportados en la literatura 6,10 . Sin em- bargo, hay algunos estudios que presentaron más casos en paladar que en glándula submandibular, por lo tanto, aún no existe un patrón definido 2,12,14 . No registramos ningún caso en glándula sublingual de manera similar a otros estudios 10,12,14 , lo cual confirma la rareza de tumores salivales en esta zona.…”

Immunohistochemical and karyometric similarities and differences of salivary gland tumors between pleomorphic adenoma, basal cell adenoma and polymorphous low grade adenocarcinoma

“…Male pljuvačne žlezde su mesta sa najčešćom frekvencijom malignih tumora 3,4 . Epidemiološki podaci prikazuju različitu učestalost u različitim etničkim grupama i delovima sveta, što dodatno otežava globalnu incidenciju ovih tumora 5,6 . Prosečna starost bolesnika je 46-47 godina, ali pik pojedinih tumora je u šestoj i sedmoj deceniji života 2 .…”

“…Minor salivary glands are the sites with the highest incidence of malignant tumors 3,4 . Epidemiological data show a different incidence in different ethnic groups and parts of the world, which further complicates the global incidence of these tumors 5,6 . The mean age of patients is 46-47 years, but the peak of some tumors is in the sixth and seventh decade of life 2 .…”

Uncovering the role of brain‐derived neurotrophic factor/tyrosine kinase receptor B signaling in head and neck malignancies

“…Salivary gland tumors (SGT) are a rare and heterogeneous group of neoplasms responsible for 3%‐5% of head and neck neoplasms . The main treatment option is surgery, leading to significant morbidity and variable survival rates.…”