Can SHED or DPSCs be used to repair/regenerate non-dental tissues? A systematic review of in vivo studies

Daltoé, Felipe Perozzo; Mendonça, Priscila Pedra; Mantesso, Andréa; Deboni, Maria Cristina Zindel

doi:10.1590/1807-3107bor-2014.vol28.0037

Cited by 33 publications

(33 citation statements)

References 32 publications

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“…According to investigations [Miura et al, 2003;Petrovic and Stefanovic, 2009;Kerkis and Caplan, 2012;Annibali et al, 2014, Daltoé et al, 2014, SHED proved to have multilineage differentiation capacity into other MSC ( table 1 ), with the ability to differentiate in vitro and in vivo into osteoblasts, odontoblasts, chondrocytes, adipocytes, and skin and neural cells.…”

Section: Properties Of Shedmentioning

confidence: 98%

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Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature

Saez

Sasaki

Neves

et al. 2016

Cells Tissues Organs

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Adult stem cells research has been considered the most advanced sort of medical-scientific research, particularly stem cells from human exfoliated deciduous teeth (SHED), which represent an immature stem cell population. The purpose of this review is to describe the current knowledge concerning SHED from full-text scientific publications from 2003 to 2015, available in English language and based on the keyword and/or abbreviations ‘stem cells from human exfoliated deciduous teeth (SHED)', and individually presented as to the properties of SHED, immunomodulatory properties of SHED and stem cell banking. In summary, these cell populations are easily accessible by noninvasive procedures and can be isolated, cultured and expanded in vitro, successfully differentiated in vitro and in vivo into odontoblasts, osteoblasts, chondrocytes, adipocytes and neural cells, and present low immune reactions or rejection following SHED transplantation. Furthermore, SHED are able to remain undifferentiated and stable after long-term cryopreservation. In conclusion, the high proliferative capacity, easy access, multilineage differentiation capacity, noninvasiveness and few ethical concerns make stem cells from human exfoliated deciduous teeth the most valuable source of stem cells for tissue engineering and cell-based regenerative medicine therapies.

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Section: Properties Of Shedmentioning

confidence: 98%

“…Nevertheless, there are no in vivo studies in humans because of the relative novelty of this research area, and there is most likely insufficient research to enable the approval of human testing or clinical protocols [Daltoé et al, 2014].…”

Section: Properties Of Shedmentioning

confidence: 99%

Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature

Saez

Sasaki

Neves

et al. 2016

Cells Tissues Organs

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“…MSC was first isolated from the adult dental pulp by Gronthos et al [45] and, then, from primary dentition extracted during periodontal and oral surgery [46]. DPSC from primary dentition presented higher proliferative capacity and differentiation potential, compared to DPSC from permanent teeth [47]. Still, scientific interest has lately turned to adult DPSC because the processing and storage of stem cells from primary dentition is not possible for the majority of the population [29].…”

Section: Dental Pulp Stem Cells (Dpsc) Role In Periodontal Regenerationmentioning

confidence: 99%

Advanced Regenerative Techniques Based on Dental Pulp Stem Cells for the Treatment of Periodontal Disease

Seciu¹,

Crăciunescu²,

Zarnescu³

2019

Periodontology and Dental Implantology

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Recent progress in periodontology intended to reduce the risk represented by periodontal disease for systemic disorders and general human health condition. In this chapter, we overview the advantages and limitations of current techniques based on occlusive membranes for periodontal regeneration. Special emphasis is paid to advanced techniques using stem cells from dental pulp for the regeneration of bone defects caused by the chronic periodontal disease. Stem cells isolation, in vitro expansion and characterization techniques are presented. Therapeutic strategies of stem cells delivery using natural polymeric carriers are discussed. Stem cell-scaffold constructs application in bone tissue engineering is proposed, taking into account the marked decline of healing, and regenerative processes in elderly individuals. Future researchers envisage multiple effects of engineered constructs with antimicrobial, anti-inflammatory, and regenerative activity for periodontal treatment.

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“…Five general bone progenitor cell types are currently been used for bone regeneration: embryonic stem cells; fetal stem cells (e.g., fetal mesenchymal stem cells [MSCs]); human umbilical vein endothelial cells; induced pluripotent stem cells (iPSCs) [22,23]; and adult stem cells (e.g., bone marrow stromal cells, bone marrow-derived MSCs, adipose-derived MSCs [24,25], muscle-derived MSCs) [26,27], dental pluripotent stem cells [28], and iPSCs. Thus far, bone marrow-derived MSCs have shown the greatest bone repair potential.…”

Section: Cell-based Therapiesmentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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Can SHED or DPSCs be used to repair/regenerate non-dental tissues? A systematic review of in vivo studies

Cited by 33 publications

References 32 publications

Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature

Stem Cells from Human Exfoliated Deciduous Teeth: A Growing Literature

Advanced Regenerative Techniques Based on Dental Pulp Stem Cells for the Treatment of Periodontal Disease

The Potential Impact of Bone Tissue Engineering in the Clinic

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