Severe Acute Respiratory Syndrome by COVID-19 in pregnant and postpartum women

Abstract

Objectives: to evaluate the morbidity and mortality profile and factors associated with death due to severe acute respiratory syndrome (SARS) by COVID-19 in pregnant and postpartum women. Methods: this is a quantitative and retrospective research that analyzed the SIVEP-gripe Database (Influenza Epidemiological Surveillance Information System), from 01/01/2020 to 04/01/2021. All pregnant women and postpartum women diagnosed with SARS caused by COVID-19 in the State of Minas Gerais were included. After the descriptive analysis of the hospitalizations profile, the association between different exposure variables and the occurrence of death was evaluated. Results: of the 227 records obtained, 94.3% required hospitalization. Among hospitalizations in the Intensive Care Unit, 29.8% used invasive ventilatory support. Fifteen deaths were recorded. The most frequent clinical manifestations were: cough and fever; the predominant comorbidities were cardiovascular disease and diabetes mellitus. The variables “ICU stay”, “use of ventilatory support” and “heart disease” were associated with the occurrence of deaths. Conclusions: hospitalization was necessary for most pregnant women with SARS and the presence of previous heart disease increased the risk of death. Knowing the SARS morbidity and mortality profile is important in the definition of public health strategies aimed at reducing the impacts of COVID-19 during pregnancy and the puerperium.

Fatores associados à gravidade da COVID-19 em gestantes adolescentes brasileiras: estudo de base populacional

“…Entre as 282 gestantes adolescentes incluídas na análise, a mediana de idade foi de 17 (11)(12)(13)(14)(15)(16)(17)(18)(19) A taxa de internação em UTI foi elevada (14,5%).…”

“…No presente estudo pouco menos da metade das gestantes adolescentes com COVID-19 possuía comorbidade e tal condição dobrou o risco de precisar de UTI. A asma e as cardiopatias foram as mais frequentes, sendo as mesmas comorbidades encontradas em outras pesquisas nacionais com gestantes (14,17) (18) . Revisão sistemática que incluiu mais de 190 pesquisas e comparou mulheres gestantes e não gestantes apontou que a presença de comorbidade constitui fator de risco para piores desfechos entre mulheres grávidas (19) .…”

“…A Sociedade Brasileira de Cardiologia (20) , em posicionamento sobre a COVID- (17,21) . Pesquisas nacionais (21)(22) (21) .…”

“…no terceiro trimestre gestacional, estando essa taxa entre 45,8% e 66,7% das gestantes (14,17) . Dos sinais e sintomas observados nos estudos nacionais e internacional (14,17,(24)(25) , as gestantes adolescentes apresentaram com maior frequência febre e tosse.…”

Factors associated with COVID-19 severity among Brazilian pregnant adolescents: a population-based study

“…Among all 282 pregnant adolescents included in this study, the median age was 17 (11)(12)(13)(14)(15)(16)(17)(18)(19) years; most of them had brown skin color (68.8%), were in the third trimester of pregnancy (64.6%), and lived in urban or peri-urban areas (83.7%). Also, 37.7% lived in the Northeast region and 24.1% had completed the late years of elementary school; however, the education variable was absent in 45.0% of the cases (Table 1).…”