Maternal folic acid consumption during gestation and its long-term effects on offspring's liver: a systematic review

Brasil, Flávia Bittencourt; Amarante, Luiz Henrique; Oliveira, Marcos Roberto de

doi:10.1590/1806-93042017000100002

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…14 Nowadays, some studies have evaluated the impact of FA maternal intake besides those related to nervous system disorder prevention. Previously our group reported by systematic review that such supplementation during gestation exerted protective effects on liver of offspring in adulthood, 24 avoiding deleterious epigenetic changes and improving the cell defenses, especially in hostile maternal conditions, such as, alcohol exposition and deprivation of protein. Several studies agree about the importance of FA intake during gestation as a way of to prevent congenital malformations, but, some of them have questioned what would be the ideal doses and proposed that the ingestion of high quantities could trigger of some damages to descendants.…”

Section: Gestation and Folic Acidmentioning

confidence: 99%

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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Supplementation with folic acid (FA) during gestation has been recommended by medical society all over the world, but some studies have shown that intake of high folic acid diet may unleash damages to the descendants. Objectives: Describing the effects of maternal supplementation with FA during gestation on offspring's kidney at late life stages. Data Source: It is a systematic review by which were consulted the following databases: Medline, through Pubmed, Lilacs, and SciELO. The research was performed using the keywords “Folic acid”, “Gestation” and “Kidney”. Study Selection: Eight studies were regarded for this systematic review. Data Collection: Only studies that evaluated folic acid consumption during gestation and its effects exclusively on descendants' kidney at several phases of life were regarded. Results: Gestational FA intake did not change the renal volume, glomerular filtration rate and the expression of some essential genes in the kidney of puppies whose dams were supplemented with FA. Maternal consumption of double FA plus selenium diet was effective in preserving antioxidant enzymes activity in the kidney of descendants from mothers exposed to alcohol. FA supplementation decreased some gross anomalies in the puppies caused by teratogenic drug despite of had not been effective in preventing some renal architectural damages. Conclusion: FA supplementation did not cause renal toxicity; it exerted an antioxidant protective effect and mitigated some renal disorders caused by severe aggressions.

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Section: Gestation and Folic Acidmentioning

confidence: 99%

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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“…Além dos defeitos do tubo neural, em estudos com ratos, segundo uma revisão sistemática 72 , afirmou-se que pode ocorrer hipometilação de genes no fígado dos descendentes caso a dieta da mãe durante a gestação tenha sido privada de proteína e ácido fólico. Porém, os autores afirmam que, com a ingestão de grandes quantidades de ácido fólico, mesmo que a dieta da mãe esteja baseada em baixas quantidades de proteína, se pode evitar a hipometilação desses genes, diminuindo a chance de ocorrerem mutações nas células do fígado.…”

Section: O áCido Fólico Na Embriogêneseunclassified

Transtorno do espectro autista e a suplementação por ácido fólico antes e durante a gestação

Maia

Menezes

Tenorio

et al. 2019

J. bras. psiquiatr.

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RESUMO Objetivo Elucidar se a suplementação com ácido fólico pouco antes da concepção e/ou durante a gestação pode estar realmente atrelado ao desenvolvimento do transtorno do espectro autista (TEA). Metódos Foi realizada uma revisão de literatura em base de dados, nos idiomas português e inglês, durante o período de novembro de 2017 até abril de 2018, com ênfase nas publicações mais recentes. Resultados Do total de 174 artigos, 87 compuseram este trabalho. Pesquisas apontam que o aumento dos casos de TEA se deve ao fato de que mais fatores genéticos estejam implicados na etiopatogênese neural. No entanto, a grande maioria dos artigos ressalta com maior precisão que há mais efeitos benéficos do uso de ácido fólico antes da concepção e durante a gestação na prevenção do TEA, assim como de outras anormalidades relacionadas aos defeitos do tubo neural. Conclusão Quando se analisa o risco-benefício da suplementação com ácido fólico nas doses recomendadas, 0,4 a 0,8 mg/dia, conclui-se que os benefícios sobrepujam os possíveis riscos de desenvolver o TEA.

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Biological Pathways Associated with Vitamins in Autism Spectrum Disorder

Gusso,

Prauchner,

Rieder

et al. 2023

Neurotox Res

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Maternal folic acid consumption during gestation and its long-term effects on offspring's liver: a systematic review

Abstract: Objectives: describing the effects of maternal supplementation with folic acid (FA)

Cited by 4 publications

References 52 publications

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Transtorno do espectro autista e a suplementação por ácido fólico antes e durante a gestação

Biological Pathways Associated with Vitamins in Autism Spectrum Disorder

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