Epileptic seizures in children with congenital Zika virus syndrome

Alves, Lucas Victor; Cruz, Danielle Di Cavalcanti Sousa; Linden, Ana Maria Campos van der; Falbo, Ana Rodrigues; Mello, Maria Júlia Gonçalves de; Paredes, Camila Esteves; Silva, Germanna Virgínya Cavalcanti; Figueirôa, José Natal; Bezerra, Patrícia Gomes de Matos

doi:10.1590/1806-9304201600s100003

Cited by 25 publications

(39 citation statements)

References 9 publications

(12 reference statements)

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“…According to Goldstein & Slomski , epilepsy is also present in other congenital infections, about 40% in toxoplasmosis and much less frequent in cytomegalovirus and herpes congenital infection. In the present study, the majority of the children presented these symptoms, corroborating with Alves et al, , who performed a cohort study showing that children with CZS had a high incidence of epileptic seizures with early onset, with spasm being the most observed type of crisis.…”

Section: Discussionsupporting

confidence: 92%

“…These data are also demonstrated in the United Nations Development Program (UNDP), which describes the social and economic impact that Zika virus, as well as other diseases, cause to a much greater extent in low-income populations, since they are people who have less access to treated water, sanitation, and education regarding daily health care as well as those in higher housing density per household. All these factors facilitate the proliferation of the vector hence the population becoming more vulnerable (PNUD, 2017 In the present study, the majority of the children presented these symptoms, corroborating with Alves et al, 2016, who performed a cohort study showing that children with CZS had a high incidence of epileptic seizures with early onset, with spasm being the most observed type of crisis.…”

Section: Ta B L Esupporting

confidence: 87%

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Dental changes in children with congenital Zika syndrome

et al. 2019

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Objective To describe oral alterations in children with congenital Zika syndrome (CZS). Methods This was a case series, whose research instrument was a structured questionnaire, associated with the use of medical record data and extra and intraoral clinical examination. Results Thirty‐two children were evaluated, the majority male (18/32%–56.3%), mean age 22 months (SD = 2.71). It was also observed that the majority of the patients (19/32%–59.4%) presented a low family income. All the children had a mean head circumference of 29.43 cm (SD = 1.42). Regarding the alterations, an ogival‐shaped palate was observed in 14 children (43.7%), and delayed chronology of eruption was observed in 15 children (46.9%), of whom 7 children (21.9%) did not present eruption of the upper left lateral incisor (p = .0002) and upper right lateral incisor (p = .002) until the moment of analysis. Additionally, 03 children with yellowish dental pigmentation were identified in erupted teeth after the onset of phenobarbital use. Enamel hypoplasia was identified in 9 children (28.1%) and only one child with ankyloglossia. Conclusion CZS may present delayed chronology of eruption, ankyloglossia, ogival‐shaped palate, and enamel hypoplasia, requiring dental follow‐up aimed at prevention, promotion, and rehabilitation of the health of these children.

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Section: Discussionsupporting

confidence: 92%

Section: Ta B L Esupporting

confidence: 87%

Dental changes in children with congenital Zika syndrome

et al. 2019

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“…Among the case series in which researchers report epilepsy, 5,10,12,51,63 a variety of EEG abnormalities were found, with multifocal discharges being the most prevalent; onset in early infancy was also documented. Only 1 report documented the clinical types of seizures 63 ; 17 of 40 (43%) seizures were described as spasms.…”

Section: Figurementioning

confidence: 99%

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Linden²,

et al. 2018

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Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities and epilepsy in infants with evidence of congenital ZIKV infection and provide information on the impact of these conditions. Specific scenarios are used to illustrate the complex clinical course in infants with abnormalities that are consistent with congenital Zika syndrome. A search of the English-language medical literature was done to identify motor abnormalities and epilepsy in infants with evidence of congenital ZIKV infection by using Medline and PubMed, Embase, Scientific Electronic Library Online, Scopus, the OpenGrey Repository, and the Grey Literature Report in Public Health. Search terms included "Zika" only and "Zika" in combination with any of the following terms: "epilepsy," "seizure," "motor," and "cerebral palsy." Clinical features of motor abnormalities and epilepsy in these children were reviewed. Thirty-six publications were identified; 8 were selected for further review. Among infants with clinical findings that are consistent with congenital Zika syndrome, 54% had epilepsy and 100% had motor abnormalities. In these infants, impairments that are consistent with diagnoses of cerebral palsy and epilepsy occur frequently. Pyramidal and extrapyramidal motor abnormalities were notable for their early development and co-occurrence. Prompt identification of potential disabilities enables early intervention to improve the quality of life for affected children. Long-term studies of developmental outcomes and interventions in children with congenital ZIKV infection are needed.

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“…Of all children, 85.4% had irritability, the most common symptom described, followed by pyramidal and extrapyramidal symptoms (56.3%), epileptic seizures (50.0%), and dysphagia (14.6%) 7 . As for the series by Alves et al 8 , which included 106 children with congenital ZIKV syndrome, 37.7% of the children had epileptic seizures in the observation period, with a median of 192-day crisis occurrence until the first report, from the date of birth. 43.3% of the seizures were characterized as spasms, 22.7% generalized tonic attacks, 20.5% were partial, and 4.5% were other types of seizures.…”

Section: Discussionmentioning

confidence: 99%

Clinical aspects of congenital microcephaly syndrome by Zika virus in a rehabilitation center for patients with microcephaly

Almeida

Martins²,

Almendra³

et al. 2019

Rev. Assoc. Med. Bras.

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OBJECTIVE: In this study, we intend to identify the prevalence of clinical variables in children with microcephaly.METHODS: This is a cross-sectional and observational study with data collected from medical records of patients admitted to the microcephaly outpatient clinic of a referral center in Teresina-PI. Demographic (gender and age) and clinical data (presence of epilepsy, dysphagia, irritability, and associated comorbidities) were collected. The frequency of Zika virus as a probable etiology was determined from computed tomography patterns and the exclusion of other etiologies by serological tests.RESULTS: A total of 67 patient records were evaluated, of which 31 were male and 36 were female, with a mean age of 1 year and 10 months. The most prevalent clinical variables were epilepsy, present in 47 children (70.2%), and irritability in 37 (55.2%). Also with a high frequency, 22 had dysphagia (32.8%), and 13 had musculoskeletal comorbidities (19.4%). Only three patients in the sample had cardiac abnormalities (4.5%), and no endocrine comorbidity was found. A total of 38 children in the sample (56.7%) presented ZIKV as a probable etiology and, in these cases, there was a higher frequency of epilepsy and dysphagia compared to other etiologies, although not statistically significant.CONCLUSION: Epilepsy, irritability, dysphagia, and musculoskeletal comorbidities were the most frequent clinical variables in children with microcephaly. There was a high prevalence of congenital ZIKV microcephaly syndrome in this sample.

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Epileptic seizures in children with congenital Zika virus syndrome

Cited by 25 publications

References 9 publications

Dental changes in children with congenital Zika syndrome

Dental changes in children with congenital Zika syndrome

Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection

Clinical aspects of congenital microcephaly syndrome by Zika virus in a rehabilitation center for patients with microcephaly

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