Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus

Koçak, Mehmet Zahid; Aktas, Gülali; Erkuş, Edip; Sıncer, İsa; Tel, Burçin Meryem Atak; Duman, Tuba Taslamacıoğlu

doi:10.1590/1806-9282.65.1.9

Cited by 107 publications

(107 citation statements)

References 16 publications

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“…These data agreed with Zeng et al, [12] which reported that UACR was higher in cases with diabetes with nephropathy than in cases with diabetes without nephropathy. Our results disagreed with results of Kocak et al, [13] who reported that there was no considerable difference of statistical significance among the two studied groups in UACR as it has been reported that a decline in the renal function of cases with DM was not always accompanied by an increased UACR.…”

Section: Discussioncontrasting

confidence: 99%

Study of Ischemia-Modified Albumin as Marker of Vascular Injury in Diabetic Nephropathy

Abd-Elaziz¹,

Hodeib

Shahba

et al. 2021

JAMMR

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Background: Diabetes mellitus (DM) is strongly correlated to ischemia caused by stress that is involved in dysfunction of endothelium leading to angiopathy, particularly diabetic nephropathy (DN). Immediately after occlusion of an artery, free radical production paired with reduced antioxidant defensive response and related ischemia in DM result in changes in the tertiary structure of human serum albumin; therefore, it is called ischemia-modified albumin (IMA). The aim of our work was to evaluate IMA as marker of vascular injury in DN. Patients and Methods: This trial was conducted on 25 normal individuals as a control group (I) and 75 cases with type II DM. Cases have been subdivided into Group II: 25 diabetic cases with normal albumin in urine, Group III: 25 diabetic cases with albumin in urine and glomerular filtration rate >60 ml/min/1.73m2 and Group IV: 25 diabetic cases with albuminuria and glomerular filtration rate <60ml/min/1.73m2. Medical history, clinical features and laboratory investigations which include the serum IMA have been carried out to all cases. Results: Compared to the control group, considerably greater serum levels of IMA have been reported in Diabetic cases there had been a wide variation in IMA among the 4 groups. There were considerable +ve correlations among serum IMA and DM duration, blood urea, serum creatinine, UACR, FBS, PPBS and HBA1c. A considerable -ve correlation among serum IMA and eGFR was observed. IMA had an optimal cutoff value≥90 ng/ml with 0.92 area under ROC curve, 96% sensitivity and 92% specificity (p-value<0.001). Conclusion: IMA could function as a glycemic control marker and a sensitive indicator for DN.

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Section: Discussioncontrasting

confidence: 99%

Study of Ischemia-Modified Albumin as Marker of Vascular Injury in Diabetic Nephropathy

Abd-Elaziz¹,

Hodeib

Shahba

et al. 2021

JAMMR

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“…These proinflammatory muscle growth factors can be induced through autocrine/paracrine manner and cause muscle dysfunction, triggering and sustaining the development of the SO. 33 Moreover, multiple factors in the inflammatory response are closely associated with chronic conditions including obesity, 34 metabolic syndrome, 35 type 2 diabetes 36,37 and coronary heart disease, 38 which all promote to SO. Studies have shown that inflammatory factors are associated with type 2 diabetes, and the increase in white blood cells is mainly due to neutrophil count, while the neutrophil to lymphocyte ratio (NLR) in type 2 diabetes patients is increased compared with the healthy control group.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

Yin¹,

Zhang²,

Wang³

et al. 2021

DMSO

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Objective Sarcopenic obesity is associated with several negative health outcomes. However, there are only a few studies on the relationship between SO and metabolic diseases such as diabetes, hypertension, and abnormal lipid metabolism in Chinese adults. The aim of this work was to evaluate the association between SO and hypertension, diabetes, and abnormal lipid metabolism in Chinese adults, and explore the prediction of SO using relevant anthropometric indicators. Materials and Methods All participants underwent a questionnaire interview for the collection of demographic data. Thereafter, they underwent physical examination for the measurement of anthropometric variables, which was performed using bioelectrical impedance analysis. Biochemical measurements were determined according to standard laboratory procedures used for the evaluation of blood parameters. Results We included 14,926 patients aged 35–74 years old. The mean age of the participants was 56.75 ± 9.76 years old, and 39.80% of them were male. The mean body mass index (BMI) was 24.94 ± 3.40 kg/m 2 , and the overall prevalence of SO was 65.1%. The results showed that shorter people; people with faster heart rate; heavier weight; lower waist circumference (WC), BMI, triglyceride level, total cholesterol, and low-density lipoprotein cholesterol levels; and higher high-density lipoprotein cholesterol level are at risk for SO. Conclusion The prevalence of SO is high (65.1%) in Chinese adults aged 35–74 years old. The occurrence of SO is related to hypertension, diabetes, and abnormal lipid metabolism. BMI, WC, and waist-hip ratio may be predictive indicators of SO. The incidence of SO may be reduced by timely intervention and health education for persons at risk of the condition.

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“…5 Hyperuricemia has drawn much attention in recent decades, as patients with hyperuricemia often present with metabolic diseases, cardiovascular diseases and cardiometabolic related complications. 6,7 Regarding diabetes, various longitudinal studies have demonstrated that higher baseline levels of serum uric acid increased the risk of developing type 2 diabetes, and a meta-analysis of 11 cohort studies including 42,834 participants indicated a 17% increase in the risk of type 2 diabetes for each 1 mg/dl increase in SUA. [8][9][10] Thus, how uric acid contributes to the pathophysiology of type 2 diabetes deserves research.…”

Section: Introductionmentioning

confidence: 99%

The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study

Huang

Wang

et al. 2021

DMSO

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Purpose Higher serum levels of uric acid (SUA) are associated with an increased risk of developing type 2 diabetes. Meanwhile, insulin resistance and beta-cell dysfunction are critical factors that mediate the progression from normal glucose tolerance to impaired fasting glucose (IFG) and type 2 diabetes. We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes. Patients and Methods We used cross-sectional data from the China Health and Nutrition Survey to examine the association. Insulin resistance and beta-cell dysfunction were estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index and homeostasis model assessment of beta-cell function (HOMA-beta) index, respectively. The associations were analyzed by using partial correlation analysis and multivariate logistic regressionl analysis. Results SUA levels were positively associated with fasting glucose, fasting insulin, HOMA-IR in the total population. After adjustment for age, drinking, smoking, living area, daily dietary nutrient intake, body mass index (BMI), estimated glomerular filtration rate (eGFR), hypertension, and dyslipidemia, compared with participants in the lowest quartile of SUA, the adjusted odds ratios for the fourth quartiles were 1.56(1.09-2.24) for IFG, 1.51(1.27-1.78) for insulin resistance, and 1.06(0.88-1.27) for beta-cell dysfunction. In the subgroup analysis, no interactions were found between serum uric acid and age, drinking status, smoking status, BMI, hypertension, or dyslipidemia (all p for interaction>0.05). Conclusion In nondiabetic individuals, SUA levels are independently associated with IFG and insulin resistance, while no significant association exists between SUA and beta-cell dysfunction.

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Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus

Cited by 107 publications

References 16 publications

Study of Ischemia-Modified Albumin as Marker of Vascular Injury in Diabetic Nephropathy

Study of Ischemia-Modified Albumin as Marker of Vascular Injury in Diabetic Nephropathy

The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study

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