The Association Between Sarcopenic Obesity and Hypertension, Diabetes, and Abnormal Lipid Metabolism in Chinese Adults

Abstract

Objective Sarcopenic obesity is associated with several negative health outcomes. However, there are only a few studies on the relationship between SO and metabolic diseases such as diabetes, hypertension, and abnormal lipid metabolism in Chinese adults. The aim of this work was to evaluate the association between SO and hypertension, diabetes, and abnormal lipid metabolism in Chinese adults, and explore the prediction of SO using relevant anthropometric indicators. Materials and Methods All participants underwent a questionnaire interview for the collection of demographic data. Thereafter, they underwent physical examination for the measurement of anthropometric variables, which was performed using bioelectrical impedance analysis. Biochemical measurements were determined according to standard laboratory procedures used for the evaluation of blood parameters. Results We included 14,926 patients aged 35–74 years old. The mean age of the participants was 56.75 ± 9.76 years old, and 39.80% of them were male. The mean body mass index (BMI) was 24.94 ± 3.40 kg/m 2 , and the overall prevalence of SO was 65.1%. The results showed that shorter people; people with faster heart rate; heavier weight; lower waist circumference (WC), BMI, triglyceride level, total cholesterol, and low-density lipoprotein cholesterol levels; and higher high-density lipoprotein cholesterol level are at risk for SO. Conclusion The prevalence of SO is high (65.1%) in Chinese adults aged 35–74 years old. The occurrence of SO is related to hypertension, diabetes, and abnormal lipid metabolism. BMI, WC, and waist-hip ratio may be predictive indicators of SO. The incidence of SO may be reduced by timely intervention and health education for persons at risk of the condition.

Prevalence and risk factors of sarcopenia without obesity and sarcopenic obesity among Chinese community older people in suburban area of Shanghai: A cross-sectional study

“…We also found that males have a significantly higher risk for SO than females (OR = 1.981, 95% CI: 1.351-2.904). These results were not consistent with previous studies, which were mostly conducted in urban areas (Wagenaar et al, 2021;Yin et al, 2021). It may be due to the difference in PA levels between males and females in the Chongming District.…”

Association of Obesity, Sarcopenia, and Sarcopenic Obesity With Hypertension in Adults: A Cross-Sectional Study From Ravansar, Iran During 2014–2017

“…Sarcopenic obesity represents a combination of sarcopenia and obesity, which means unusual muscle loss, coinciding with fat accumulation (23). Studies suggest that when obesity and muscle loss co-exist, they can synergistically increase the risk of several diseases (23,24). According to cohort studies conducted in Korea (14,25) and the United States (26), sarcopenic obesity was related to increasing the risk of hypertension.…”

Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

“…When sarcopenia and obesity coexist, this condition is called sarcopenic obesity (SO). SO is a geriatric syndrome and a critical risk factor for death among elderly [ 6 , 7 ]. T2DM is characterized by insulin resistance, increased advanced glycation end-products (AGEs), a proinflammatory phenotype and oxidative stress, which can lead to micro- and macro-vascular complications [ 8 , 9 ].…”

“…The prevalence of sarcopenia in T2MD is reported to be high, especially in patients with poor glycemic control [ 4 – 6 ]. Skeletal muscle inflammation is the key to muscle loss and an important step in sarcopenia.…”