Translation and validation of Hyperhidrosis Disease Severity Scale

Varella, Andrea Yasbek Monteiro; Fukuda, Juliana Maria; Teivelis, Marcelo Passos; Campos, José Ribas Milanez de; Kauffman, Paulo; Cucato, Gabriel Grizzo; Puech-Leão, Pedro; Wolosker, Nelson

doi:10.1590/1806-9282.62.09.843

Cited by 22 publications

(19 citation statements)

References 11 publications

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“…The HDSS is a scale for the assessment of disease severity and daily life impairment in patients with hyperhidrosis. It is a single item asking the patient to rate the severity of their hyperhidrosis on a four‐point scale 4,15 . The DLQI consists of 10 questions concerning patients’ perception of the impact of skin diseases on aspects of their QoL over the last week 16 .…”

Section: Methodsmentioning

confidence: 99%

Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III randomized controlled trial*

et al. 2020

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Summary Background The Hyperhidrosis Quality of Life Index (HidroQoL©) is a validated patient‐reported outcome measure capturing the quality of life of people affected by hyperhidrosis. Objectives We aimed to extend the validity evidence to physician‐confirmed diagnosis of primary axillary hyperhidrosis. Methods Data from a phase III randomized placebo‐controlled clinical trial were used (n = 171). Confirmatory factor analysis was carried out to confirm the a priori two‐factor structure of the HidroQoL. Internal consistency was assessed using Cronbach’s α. Intraclass correlation coefficients (ICCs) were calculated to evaluate test–retest reliability after days –7 to –4. Convergent validity was assessed using correlations with the Dermatology Life Quality Index (DLQI), the Hyperhidrosis Disease Severity Scale (HDSS) and gravimetric sweat production. Known groups were analysed to evaluate discriminative validity. Responsiveness after 29 days was assessed and minimal important difference (MID) values were calculated using both anchor‐ and distribution‐based approaches. All analyses were carried out for total HidroQoL and its two domains. Results The two‐factor structure of the HidroQoL was confirmed. Internal consistency and test–retest reliability were strong (Cronbach’s α 0·81–0·90; ICCs 0·89–0·93). Correlations with other outcome measures were in line with a priori hypotheses. The HidroQoL discriminated between different severity groups (P ≤ 0·001) and showed sensitivity to change towards improvement (P < 0·001). An MID value of 4 is proposed for the total scale. Conclusions This study supports excellent measurement properties including clinical applicability of the HidroQoL in primary axillary hyperhidrosis and suggests a MID of 4 be applied to clinical trial data.

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Section: Methodsmentioning

confidence: 99%

Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III randomized controlled trial*

et al. 2020

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“…It has been employed by almost every single PH prevalence study to this date and was recently translated and validated into Portuguese. [26]…”

Section: Methodsmentioning

confidence: 99%

Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro

et al. 2019

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BackgroundHyperhidrosis is a pathological condition defined by excessive sweating beyond thermoregulatory physiological needs, which can cause substantial psychological impact and impairment of daily activities. Studies regarding its prevalence, however, are scarce and vary widely in their findings. The population of medical students is a particularly interesting subset for its recurring demand of physical contact during patient examination or procedures, and the potential for professional adversity. We aimed at furthering the comprehension of this disease prevalence and characteristics among medical students.MethodsQuestionnaires inquiring about the presence and characteristics of Primary Hyperhidrosis (PH) were applied through either written or digital means to all eligible medical students enrolled in three Medical Schools in the State of Rio de Janeiro who agreed to take part in the study. Demographic data regarding gender, ethnicity, current age, weight and height was collected in addition to clinical data (sweat site, age of onset, familial history, severity and previous treatments). Severity was evaluated through the Hyperhidrosis Disease Severity Scale (HDSS) and a symptoms survey.FindingsOur response rate was roughly 1/3 of all eligible students (900/2700). PH prevalence was 20.56% (185/900). It was similar between men and women (23.08% and 19.41%, respectively) and strongly associated with family history of the disease (Prevalence Ratio of 4.27). Regarding ethnicity, of the total sample 73.78% (664/900) self-declared white, among which 19.28% (128/664) had PH. Mixed-race and other ethnicities encompassed 26.22% (236/900) of the sample, among which 24.15% (57/236) had PH. Most positive subjects (64.32%) presented associated forms of PH. Overall involvement of each site (both associated and isolated) was: 63.78% axillary, 50.81% palmar, 43.24% plantar, 20.54% craniofacial, 18.38% facial flushing and 2.16% gustatory sweating. Mean current age was 23.11(±4.04) years for PH patients, and age of onset was ≤18 years in 93.94% of cases. Regarding body mass index (BMI), 71.09% of PH patients had BMI<25kg/m2 and only 4.69% presented BMI≥30kg/m2, none ≥35kg/m2. Some degree of life quality impairment was reported by 89.20% of PH patients, and 23.89% had HDSS 3 or 4 (moderate to severe).ConclusionsPH prevalence among Rio de Janeiro medical students was 20.56%, similar between men and women, predominating associated presentations, axillary, palmar and plantar sites, strong familial history, age of onset before 18 years, and some degree of life impairment.

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“…Score 1 indicates absence of excessive sweating; score 2 moderate hyperhidrosis, with 3 and 4 corresponding to severe hyperhidrosis. Studies have shown a good correlation with gravimetric indices where a two-point reduction in scale indicates an 80% drop in sweat production [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

A prospective controlled randomized multicenter study to evaluate the severity of compensatory sweating after one-stage bilateral thoracic sympathectomy versus unilateral thoracic sympathectomy in the dominant side

Hamilton

Tedde

Wolosker

et al. 2020

Contemporary Clinical Trials Communications

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Objective To evaluate the contribution that unilateral thoracic sympathectomy in dominant side or two-stage bilateral thoracic sympathectomy can have as strategies to reduce the incidence of compensatory sweating after sympathectomy for palmar hyperhidrosis. Methods This is a prospective, controlled, randomized multicenter trial of 200 participants with palmar hyperhidrosis, which will be randomized into two arms: (a) one-stage bilateral thoracic sympathectomy (control arm); or (b) unilateral thoracic sympathectomy in dominant side (intervention arm). At six months the participants submitted to unilateral procedure can make the contralateral surgery if they wanted it, creating a third group called two-stage bilateral sympathectomy. Participants will be evaluated for the degree of sweating by the Hyperhidrosis Disease Severity Scale (HDSS) and of quality of life questionnaires. Results 96 participants out of the 200 proposed have been included so far, with 48 participants randomized to each arm. From the sample 61 (63.5%) are female, with a mean age of 24 (20–32) years. There were exclusive palmar hiperhydrosis in 14 cases (14.5%), palmar and plantar hyperhidrosis in 36 (37.5%) cases, palmar and axillar hyperhidrosis in 12 (12,5%) cases and palmar-axillary-plantar hyperhidrosis in 34 (35,4%) cases. The age at the beginning of the disease was childhood (78%), with mean of time of disease 15 (11–22) years. Conclusions If one or both hypothesis: (a) unilateral sympathectomy in dominant hand is a satisfactory treatment; b) two-stage bilateral sympathectomy causes less compensatory sweating than in one stage are confirmed there is a chance that surgical therapy for palmar hyperhidrosis can be changed for better.

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Translation and validation of Hyperhidrosis Disease Severity Scale

Cited by 22 publications

References 11 publications

Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III randomized controlled trial*

Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III randomized controlled trial*

Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro

A prospective controlled randomized multicenter study to evaluate the severity of compensatory sweating after one-stage bilateral thoracic sympathectomy versus unilateral thoracic sympathectomy in the dominant side

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