Metaplastic squamous cell carcinoma of the breast: A case report and literature review

Graziano, Luciana; Filho, Paschoal Graziano; Bitencourt, Almir Galvão Vieira; Soto, Daniel Bernal; Hiro, Alexandre; Nunes, Cíntia Camillo

doi:10.1590/1806-9282.62.07.618

Cited by 13 publications

(23 citation statements)

References 5 publications

(12 reference statements)

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“…Clinically, these patients had been reported to present with an average palpable breast lump size of more than 4 cm at diagnosis, which is larger than that of breast adenocarcinoma (2). Though metaplastic cancer of high grade squamous subtype has been known to be rapidly growing (3), the extent of rapid growth is not well documented as all the reports relied on the patient's account and may hence have recall bias.…”

Section: Case Presentationmentioning

confidence: 99%

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Natural history of metaplastic squamous cell breast cancer: a case report and literature review on surgical management

2017

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Metaplastic squamous cell breast cancer is an extremely rare subtype, accounting for less than 1% of all invasive breast cancers. As a result, there is sparse data in literature relating to its presentation and management. We report the first known case of metaplastic squamous cell breast cancer which was detected on screening mammogram and followed up as the patient delayed her treatment. This case highlights the aggressive natural behaviour of this subtype and importance of early treatment. The surgical management of this rare entity was reviewed.

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Section: Case Presentationmentioning

confidence: 99%

“…There is little data on the optimal treatment regimen for metaplastic squamous cell breast cancer, and its management remains similar to that for IDCs (2). While review of the various treatment modalities has been reported for metaplastic squamous cell breast cancer, sparse reports have focused on surgical modality alone.…”

Section: Case Presentationmentioning

confidence: 99%

Natural history of metaplastic squamous cell breast cancer: a case report and literature review on surgical management

2017

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“…Significantly, the pathological type of the first resected malignant tumor in the right breast was IDC, but after adjuvant chemotherapy and radiotherapy, the type of the recurrent mass changed to metaplastic SCC This indicated that pathological phenotypes of tumors could transform one type to another, especially for those with metaplastic components (6). Graziano et al (12) reported that IDC of the breast could progress to metaplastic SCC after induction chemotherapy. Previous research revealed that long-standing breast implants and acute unilateral breast pain and enlargement might also cause secondary PSCC of the breast (13,14).…”

Section: Discussionmentioning

confidence: 99%

Change of Pathological Type to Metaplastic Squamous Cell Carcinoma of the Breast During Disease Recurrence: Case Report and Literature Review

Guo

Chen

et al. 2020

Front. Oncol.

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Background: Metaplastic squamous cell carcinoma (SCC) of the breast is a rare and heterogeneous group of primary breast malignancies. The etiology, pathogenesis, and proper treatment for this kind rare breast cancer are still unclear. Case presentation: We reported a case of a 55-year-old woman with a palpable lump in the inner quadrant of the right breast. She underwent a right breast mass resection and sentinel lymph node biopsy, which revealed that the tumor was an invasive ductal carcinoma, followed by four cycles of doxorubicin plus cyclophosphamide and four cycles of docetaxel as adjuvant chemotherapy, and then simultaneous integrated boost intensity modulated radiotherapy to the whole right breast. After 2 years' follow-up, she had biopsy-proven disease recurrence in the right breast, which revealed SCC, and a mammogram showed abnormalities in the lower inner quadrant of the right breast and left axillary lymph nodes. Then we performed bilateral breast modified radical mastectomy, which confirmed that the recurrent tumors were metaplastic SCC, followed by adjuvant chemotherapy and adjuvant radiotherapy of the left supraclavicular and apical axillary regions. There has been no recurrent or metastatic evidence in the 16 months' follow-up since the second surgery. Conclusion: This case report shows that evolution of pathology type in recurrent breast cancer after initial treatment is possible. Detailed pathologic and immunohistochemical analyses are needed for identification of this change. Surgery and adjuvant radiation and chemotherapy are appropriate treatments for recurrent primary SCC of the breast.

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“…[4,6] Five variants of MCB were suggested by Wargotz and Norris. [7] Subsequently, the World Health Organization laid down the defining criteria for these variants [2,8] [Table 2].…”

Section: Discussionmentioning

confidence: 99%

Metaplastic carcinoma of breast: Case series with cytohistological correlation

Sood

Gupta

Soin

2019

Indian J Med Paediatr Oncol

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Metaplastic carcinoma of breast (MCB) is a rare breast malignancy. It is important to differentiate metaplastic carcinoma from malignant phyllodes and primary breast sarcomas because of their differing biological behavior and prognosis. We report four cases of MCB diagnosed over the past 15 years. Retrospective review of patient records in a tertiary care setting to retrieve cases diagnosed as MCB. Patient records of the past 15 years (2002–2015) were retrieved. Four histopathologically diagnosed cases of metaplastic carcinoma out of a total of 880 archived cases of breast carcinoma were studied along with their cytopathology. Immunohistochemistry was performed on sections. MCB comprised 0.45% of all breast malignancies. The four cases of MCB included MCB with chondroid metaplasia, spindle cell carcinoma, adenosquamous carcinoma, and carcinosarcoma. All the tumors were invariably triple negative (estrogen receptor, progesterone receptor, and Her2/Neu negative) and expression of other epithelial and mesenchymal markers was variable. MCB is a rare breast malignancy. Differential diagnosis is related to the presence of heterologous elements and degree of atypia seen in the lesion. It is important to be aware of this entity as it carries a poor prognosis.

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Metaplastic squamous cell carcinoma of the breast: A case report and literature review

Cited by 13 publications

References 5 publications

Natural history of metaplastic squamous cell breast cancer: a case report and literature review on surgical management

Natural history of metaplastic squamous cell breast cancer: a case report and literature review on surgical management

Change of Pathological Type to Metaplastic Squamous Cell Carcinoma of the Breast During Disease Recurrence: Case Report and Literature Review

Metaplastic carcinoma of breast: Case series with cytohistological correlation

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