Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

Strufaldi, Maria Wany Louzada; Souza, Fabíola Isabel Suano de; Puccini, Rosana Fiorini; Franco, Maria do Carmo Pinho

doi:10.1590/1806-9282.62.04.347

Cited by 6 publications

(4 citation statements)

References 14 publications

(20 reference statements)

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“…Many studies have shown the importance of the family history of dyslipidemia for the development of various cardiometabolic alterations, 17 , 18 however, the present study is one of the few that analyzes Brazilian children. Similar to the results found in the present study, a family history of dyslipidemia was a risk factor for its development in Chinese children.…”

Section: Discussionmentioning

confidence: 91%

O Histórico Familiar Está Associado À Presença De Dislipidemia Em Crianças Pré-Escolares

Filgueiras

Vieira

Ribeiro

et al. 2019

Rev. paul. pediatr.

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Objective: To evaluate the association between family history and the presence of dyslipidemia in children.Methods: A cross-sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson's chi-square test was used to identify associations, and Student's t-test was used to compare means. A Poisson regression analysis was performed to assess the independent association between family history and the presence of dyslipidemia in children.A significance level of 5% was adopted.Results: Children of parents with dyslipidemia had higher serum concentrations of total cholesterol and triglycerides. In a regression analysis after adjustments, the presence of dyslipidemia in the father or in the mother (OR: 2.43; 95%CI 1.12-5.27), as well as the presence of dyslipidemia in both the father and the mother (OR: 5.62; 95%CI 2.27-13.92) were associated with hypertriglyceridemia in children. Children of parents with dyslipidemia had a higher prevalence of elevated low-density lipoproteins (LDL-c) (OR:1.52; 95%CI 1.18-1.97).Conclusions: An investigation of the family history of dyslipidemia should be made as part of the protocol to verify the presence of hypertriglyceridemia and dyslipidemia in children.Keywords: Child; Parents; Dyslipidemia; Hypertriglyceridemia; Cardiovascular diseases.Objetivo: Avaliar a associação entre história familiar e presença de dislipidemias em crianças.Métodos: Estudo transversal com 257 crianças de 4 a 7 anos de idade do município de Viçosa, Minas Gerais. Foram realizadas avaliações do estado nutricional e do perfil lipídico (colesterol total e frações e triglicerídeos), além do registro de história de dislipidemia dos pais. Para análise estatística, foi utilizado o teste do qui-quadrado de Pearson para identificar associações e teste t de Student para comparação de médias. Foi realizada análise de regressão de Poisson para avaliar a associação independente entre história familiar e a presença de dislipidemia em crianças, sendo adotado o nível de significância estatística de 5%.Resultados: Crianças com pais dislipidêmicos apresentaram maiores concentrações séricas de colesterol total e triglicerídeos. Na análise de regressão após ajuste, a presença de dislipidemia no pai ou na mãe (RP: 2,43; IC95% 1,27) bem como a presença de dislipidemia no pai e na mãe (RP: 5,62; IC95% 2,92) estiveram associadas à hipertrigliceridemia nas crianças. Crianças com pais e mães dislipidêmicos apresentaram maior prevalência de lipoproteína de baixa densidade (LDL-c) elevada (RP: 1,52; IC95% 1,18-1,97). Conclusões:A investigação da história familiar de dislipidemia deve fazer parte de protocolos para verificar a presença de hipertrigliceridemia e dislipidemias na infância. Palavras INTRODUCTIONDyslipidemia occurs when lipoproteins are metabolically altered such that high serum con...

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Section: Discussionmentioning

confidence: 91%

O Histórico Familiar Está Associado À Presença De Dislipidemia Em Crianças Pré-Escolares

Filgueiras

Vieira

Ribeiro

et al. 2019

Rev. paul. pediatr.

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“…We also found higher odds of having NWO in adolescents who had a family history of dyslipidemia. The family history of diseases, such as dyslipidemias, can help in the tracking of various cardiometabolic changes [37,38], since it is based on heredity, eating habits and shared lifestyle [39]. In this way, the investigation of family history for chronic diseases can be useful in assessing the cardiometabolic risk of adolescents.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with normal-weight obesity in adolescents

et al. 2022

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A new phenotype of obesity has been studied: normal-weight obesity (NWO), which describes individuals with normal-weight by body mass index (BMI) and excess body fat. Despite normal-weight, individuals with NWO have a higher cardiometabolic risk. There is still a gap in the literature on the subject, especially in adolescents, as studies with this population are scarce. Therefore, this study aims to investigate the sociodemographic factors, family history of chronic non-communicable diseases, body perception, lifestyle and food consumption associated with NWO in adolescents. This is a cross-sectional study, conducted with 506 normal-weight adolescents aged 10 to 19 years, of both sexes. Weight and height were obtained and BMI/age was calculated. Body fat analysis was performed using dual-energy X-ray absorptiometry. Sociodemographic data, level of physical activity, food consumption, body self-perception and lifestyle habits were also obtained. Logistic regression with hierarchical approach was used to analyze the associations. The odds of NWO are greater with age (OR=1.14; 95% CI=1.04-1.26), lower in male adolescents (OR=0.21; 95% CI=0.11-0.41) and higher in those with a history of familial dyslipidemia (OR=1.81; 95% CI=1.01-3.28). Adolescents satisfied with their body (OR=0.30; 95%CI 0.16-0.56) and physically active (OR=0.44; 95% CI=0.24-0.81) have a lower odds of NWO, compared to the others. In addition, it was observed that the odds of NWO is greater among adolescents who use sweeteners (sugar substitutes) (OR=3.84; 95% CI=1.70-8.65). The factors associated with NWO were female sex, older age, positive family history of dyslipidemia, lower body satisfaction, lower level of physical activity and greater use of sweeteners.

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“…Together, TC/HDL-C and TGL/HDL-C ratios may reflect the balance between these lipoproteins and could serve as a useful marker for cardiovascular risk. These relations have been evaluated in adults and children with and without obesity [31][32][33].…”

Section: Plos Onementioning

confidence: 99%

Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study

et al. 2023

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Background Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS. Methods This was an observational study. A total of 107 children and adolescents aged 6–18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios. Results Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled. Conclusion Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.

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Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

Cited by 6 publications

References 14 publications

O Histórico Familiar Está Associado À Presença De Dislipidemia Em Crianças Pré-Escolares

O Histórico Familiar Está Associado À Presença De Dislipidemia Em Crianças Pré-Escolares

Factors associated with normal-weight obesity in adolescents

Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study

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