A narrative review on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis versus hepatocellular carcinoma: do you mind?

Toman, Daniel; Şengül, İlker; Pelikán, A; Şengül, Demet; Vávra, P; Ihnát, Peter; Roman, Jan; Kayaalp, Cüneyt

doi:10.1590/1806-9282.20220268

Cited by 5 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of hepatic inflammation is an important feature of NAFLD, especially in patients with NASH. 24 Herein, our findings supported this fact as evidenced by increased hepatic levels of pro-inflammatory cytokines TNF-α and IL-1β in experimental mice with NAFLD. Components of T. spiralis and other parasite-derived products have been reported to have antiinflammatory properties that improve inflammatory disorders in various inflammation-related disease models, such as IBD, rheumatoid arthritis, and multiple sclerosis.…”

Section: ■ Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Yang,

He,

Yang

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by hepatic steatosis, inflammation, and fibrosis, as well as gut dysbiosis. No approved effective therapeutic medicine is available to date for NAFLD. Helminth therapy is believed to be a novel direction and therapeutic strategy for NAFLD. Our previous study showed that Trichinella spiralis-derived antigens (TsAg) had the potential for partially alleviating obesity via regulating gut microbiota. However, the effect of TsAg on NAFLD remains unclear. In this study, high-fat diet (HFD)-induced model mice were treated with TsAg and microbiota transplantation experiments, and alterations in the pathogenesis of nonalcoholic liver disease were assessed. The results showed that TsAg markedly reduced hepatic steatosis, improved insulin resistance, and regulated the abnormal expression of hepatic lipid-related genes. Of note, TsAg ameliorated hepatic inflammation by decreasing proinflammatory TNF-α and IL-1β, suppressing hepatic macrophage infiltration, as well as promoting M2 macrophage polarization. Moreover, TsAg reversed gut dysbiosis, as especially indicated by an increase in beneficial bacteria (e.g., Akkermansiaceae and Rikenellaceae). Furthermore, our study found that TsAg reduced LPS hepatic translocation and hepatic TLR4/NF-κB signaling, which further contributed to inhibiting hepatic inflammation. In addition, TsAg inhibited hepatic oxidative stress involving Nrf2/NQO-1 signaling. Microbiota transplantation showed that TsAg-altered microbiota is sufficient to confer protection against NAFLD in HFDinduced mice. Overall, these findings suggest that TsAg involving gut−liver axis and Nrf2/NQO-1 signaling is a novel promising candidate for NAFLD treatment. TsAg restores intestinal microbiota and intestinal barrier to inhibit bacteria and LPS translocation into the liver, contributing to reduce inflammation, oxidative stress, and hepatic steatosis in the liver of NAFLD mice. The effects were attributed to, at least in part, the inactivation of NF-κB pathway and the activation of Nrf-2/NQO-1 pathway. This study provides new insights for understanding immune modulation by T. spiralis-derived products as well as the potential application of TsAg as a modality for NAFLD.

show abstract

Section: ■ Discussionsupporting

confidence: 80%

“…The presence of hepatic inflammation is an important feature of NAFLD, especially in patients with NASH . Herein, our findings supported this fact as evidenced by increased hepatic levels of pro-inflammatory cytokines TNF-α and IL-1β in experimental mice with NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Yang,

He,

Yang

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

show abstract

“…They also added that mostly genetic background of the individuals is significant in the development of NAFLD. Additionally, Toman et al 14 reported that obesity, a condition that is related to elevated serum TG and cholesterol levels, may cause NAFLD. However, it was also reported that obesity may be protective in patients with lung lobectomy 15 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levels

Taskin

Bağcı

Turan

2023

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

OBJECTIVE:The aim of this study was to determine frequency and associations between APOA5 c.56C>G, -1131T>C, c.553G>T, and APOC3 -482C>T and SstI gene polymorphisms with hypertriglyceridemia. METHODS: Under a case-control study model, 135 hypertriglyceridemic and 178 normotriglyceridemic control participants were recruited. Polymerase chain reaction and restriction fragment length polymorphism methods were utilized for genotyping. Statistical calculations were performed by comparing allele and genotype frequencies between groups. Clinical characteristics were compared between groups and intra-group genotypes. RESULTS: APOC3 gene -482C>T and SstI polymorphic genotypes and allele frequencies were significantly higher in hypertriglyceridemic group (genotype frequencies, p=0.035, p=0.028, respectively). Regression analysis under unadjusted model confirmed that APOC3 -482C>T and SstI polymorphisms were significantly contributing to have hypertriglyceridemia (p=0.02, odds ratio [OR]=1.831 (95% confidence interval [CI] 1.095-3.060); p=0.04, OR=1.812 (1.031-3.183), respectively). APOA5 c.56C>G was in complete linkage disequilibrium with APOA5 c.553G>T polymorphism (D'=1). CONCLUSION: For the first time in a population sample from Turkey, among the five polymorphisms of APOA5 and APOC3 genes investigated, APOC3 -482C>T and SstI polymorphisms were associated with elevated serum TG levels, while APOA5 c.56C>G, -1131T>C, and c.553G>T polymorphisms were not.

show abstract

“…The same study reported that CD8+ cells greatly increase PD-L1 expression on cancer cell lines, and PD-L1 expression and CD8+ T-cell density showed a significant positive correlation in HCC patients. 35 , 36 , 37 , 38 , 39 …”

Section: Pd-1/pd-l1/pd-l2 and Their Role In Other Tumorsmentioning

confidence: 99%

Programmed cell death-1 and its ligands: Current knowledge and possibilities in immunotherapy

Gutić¹,

Božanović²,

Mandić³

et al. 2023

Clinics

Self Cite

View full text Add to dashboard Cite

A narrative review on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis versus hepatocellular carcinoma: do you mind?

Cited by 5 publications

References 18 publications

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Effect of Trichinella spiralis-Derived Antigens on Nonalcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Investigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levels

Programmed cell death-1 and its ligands: Current knowledge and possibilities in immunotherapy

Contact Info

Product

Resources

About