Abstract:Ankylosing spondylitis, a form of axial spondyloarthritis (SpA), is a chronic inflammatory rheumatic disease and manifests itself by inflammatory back pain, radiographic sacroiliitis, and excess spinal bone formation, as well as non-skeletal manifestations such as uveitis, inflammatory bowel disease (IBD), or psoriasis 1 . Reported prevalence rates range between 0.1 and 0.5% 1,2 .Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with a key regulatory role in the inflammatory response, and impaired regulati… Show more
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