“Similitude in Modern Pharmacology”: two decades of studies contributing to the scientific basis of the homeopathic healing principle

“Similia Similibus Curentur”: The scientific grounding of the homeopathic therapeutic principle through the systematic study of the rebound effect of modern drugs

“…In accordance with its idiosyncratic nature, the rebound phenomenon appears in a small proportion of susceptible individuals; nevertheless, scientific pieces of evidence point to the occurrence of severe and fatal adverse events as a result of the paradoxical reaction of the body following the discontinuation of different categories of drugs. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 This corroborates the magnitude of the phenomenon, the need to be duly known by health care providers, and the benefits of its therapeutic application according to the similitude principle.…”

“…Bridging between the therapeutic similarity principle and modern scientific reason, hundreds of studies in the medical literature describe the occurrence of secondary reactions following and opposed to the primary actions of many categories of drugs, thus corroborating the homeopathic assumption. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 Such secondary action or reaction, which occurs automatically and instinctively to maintain the system homeostasis, is described by contemporary pharmacology and physiology as a rebound effect of drugs or a paradoxical reaction of the body, respectively. Analogously, the primary action of the drugs mentioned by Hahnemann represents the therapeutic, adverse, and side effects of modern drugs.…”

“…Since 1998, following the deductive Aristotelian reasoning employed by Hahnemann to validate the principle of therapeutic similitude, the authors have been scientifically grounding the homeopathic therapeutic principle through the systematic study of the rebound effect of several classes of modern drugs, 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 demonstrating the occurrence of a strong secondary and opposite reaction of the body after ceasing the primary action of the palliative or antagonist drugs ( Table 1 and Table 2 ).…”

“…These scientific pieces of evidence 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 demonstrate that the properties of the rebound effect of modern pharmacology are similar to the secondary action of homeopathic pharmacology ( Organon of medicine, paragraphs 59, 64, 69) 3 : 1) It induces a body reaction opposed to and of greater intensity compared to the primary action of drugs; 2) It takes place after the end of the primary action of the drug, and as the automatic manifestation of the body; 3) It does not depend on the type of drug, dose, treatment duration or category of symptoms (disease); 4) Its magnitude is proportional to the intensity of the primary action of the drug; and 5) It appears only in susceptible individuals (idiosyncrasy).…”

“Genomic Homeopathy” proposal: use of auto-isotherapic of DNA as a modulator of gene expression in chronic diseases

“…Homeopathic treatment is based on four scientific assumptions (principle of therapeutic similitude, homeopathic pathogenetic trials, prescription of individualized medicines in dynamized doses) validated in different lines of research 1,2 . Employing the principle of therapeutic similitude 3,4 as the central nucleus, homeopathy administers individualized medicines (according to the totality of symptoms) in dynamized doses (ultra-diluted and potentized), which cause similar disorders to those intended to be treated (homeopathic pathogenetic trials) 5,6 , with the aim of stimulating a vital (homeostatic) reaction of the body against its own illnesses.…”