Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma

Wang, Mujun; Liu, Wei; Liu, Wenxing; Wang, Chao

doi:10.1590/1806-9282.20210822

Cited by 7 publications

(4 citation statements)

References 26 publications

(25 reference statements)

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“…However, studies have not fully revealed the functions of LINC00173 in other cancers. On the other hand, five reports predict that LINC00173 may be involved in the development of diseases through bioinformatics analysis [ 19 , 73 , 74 , 75 , 76 ], Thus, it is necessary to study the biological function and molecular mechanism of LINC00173 in human diseases by molecular experiments.…”

Section: Discussionmentioning

confidence: 99%

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

Mao

Liao

Tang

2022

Cancers

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Long non-coding RNAs belong to non-coding RNAs (ncRNAs) with a length of more than 200 nucleotides and limited protein-coding ability. Growing research has clarified that dysregulated lncRNAs are correlated with the development of various complex diseases, including cancer. LINC00173 has drawn researchers’ attention as one of the recently discovered lncRNAs. Aberrant expression of LINC00173 affects the initiation and progression of human cancers. In the present review, we summarize the recent considerable research on LINC00173 in 11 human cancers. Through the summary of the abnormal expression of LINC00173 and its potential molecular regulation mechanism in cancers, this article indicates that LINC00173 may serve as a potential diagnostic biomarker and a target for drug therapy, thus providing novel clues for future related research.

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Section: Discussionmentioning

confidence: 99%

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

Mao

Liao

Tang

2022

Cancers

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“…Shi et al investigated the role of lncRNA H19 in melanoma and found H19 was highly expressed in melanoma tissues compared to normal adjacent skin tissues and H19 expression levels were significantly higher in patients with metastatic melanoma compared to melanoma patients without distant metastasis ( p < 0.01) [ 24 ]. Similarly, long intergenic ncRNA 173 (LINC00173) expression was significantly higher in melanoma tissues compared to adjacent non-neoplastic tissues ( p < 0.01) and was expressed more frequently in melanoma patients with distant metastasis compared to patients at an earlier stage of melanoma [ 41 ]. Another study found that lncRNA LINC02249 expression was significantly elevated in cutaneous melanoma samples and a high expression of LINC02249 was associated with shorter overall survival in melanoma patients [ 42 ].…”

Section: Melanomamentioning

confidence: 99%

Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review

Natarelli,

Boby,

Aflatooni

et al. 2023

Life

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Non-coding RNAs (ncRNAs) have a significant regulatory role in the pathogenesis of skin cancer, despite the fact that protein-coding genes have generally been the focus of research efforts in the field. We comment on the actions of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the current review with an eye toward potential therapeutic treatments. LncRNAs are remarkably adaptable, acting as scaffolding, guides, or decoys to modify key signaling pathways (i.e., the Wnt/β-catenin pathway) and gene expression. As post-transcriptional gatekeepers, miRNAs control gene expression by attaching to messenger RNAs and causing their degradation or suppression during translation. Cell cycle regulation, cellular differentiation, and immunological responses are all affected by the dysregulation of miRNAs observed in skin cancer. NcRNAs also show promise as diagnostic biomarkers and prognostic indicators. Unraveling the complexity of the regulatory networks governed by ncRNAs in skin cancer offers unprecedented opportunities for groundbreaking targeted therapies, revolutionizing the landscape of dermatologic care.

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“…We were very pleased to read the article entitled “Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma” by Wang et al 1 In this study, the authors revealed that LINC00173 expression was abnormally elevated in melanoma and may serve as a novel biomarker for predicting diagnosis and clinical progression of melanoma patients. However, some concerns need to be raised from our opinion.…”

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confidence: 99%

Comment on “Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma”

Zhu

Wang³

2022

Rev. Assoc. Med. Bras.

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LETTERS TO THE EDITOR Dear Editor,We were very pleased to read the article entitled "Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma" by Wang et al. 1 In this study, the authors revealed that LINC00173 expression was abnormally elevated in melanoma and may serve as a novel biomarker for predicting diagnosis and clinical progression of melanoma patients. However, some concerns need to be raised from our opinion.The main problem of the study was that it lacks general demographic information, inclusion criteria, and exclusion criteria. There are some factors that affect the prognosis of the melanoma, including size of tumor, status of lymph node, distant metastasis, and complication. Inclusion and exclusion criteria should also be provided. Some chronic diseases such as hypertension and diabetes that affect prognosis should be excluded.Another concern is that the definition of high expression for LINC00173 was not provided. In this study, 163 melanoma tissues and their pair-matched nontumor specimens were obtained from patients who underwent radical resections at The First People's Hospital of Jinan City from May 2012 to July 2015. LINC00173 was first reported in 2017 2 . Therefore, we can assume that the researchers used frozen samples for the experiment. It is not clear whether freezing storage of general samples would lead to RNA degradation, and whether the researchers considered the effect of freezing time on RNA levels.

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Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma

Cited by 7 publications

References 26 publications

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

Long Intergenic Non-Protein Coding RNA 173 in Human Cancers

Regulatory miRNAs and lncRNAs in Skin Cancer: A Narrative Review

Comment on “Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma”

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