Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients

Abstract

OBJECTIVE:The aim of this study was to evaluate and compare C-reactive protein and C-reactive protein-to-albumin ratio performances in predicting mortality of geriatric patients who visited the emergency department. METHODS:The data of patients with COVID-19 and aged 65 years and above, who visited emergency department during the study period, were retrospectively analyzed. The data were obtained from an electronic-based hospital information system. The area under the receiver operating characteristic curve and the area under the curve were used to assess each cutoff value discriminatory for predicting mortality. RESULTS:The mean age of the population included in this study was 76 (71-82) years, while 52.7% were males. The sensitivity, specificity, and area under the curve values for C-reactive protein in terms of mortality were calculated as 71.01, 52.34, and 0.635%, respectively, while the sensitivity, specificity, and area under the curve values for C-reactive protein-to-albumin ratio were calculated as 75.74, 47.66, and 0.645%, respectively (p<0.001). In the pairwise comparison for the receiver operating characteristic curves of C-reactive protein and C-reactive protein-to-albumin ratio, no statistically significant difference was found.CONCLUSIONS: Geriatric patients are the "most vulnerable" patient group against the COVID-19. In this study, both C-reactive protein and C-reactive protein-to-albumin ratio were found to be successful in predicting mortality for geriatric COVID-19 patients.

Comment on: “Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients”

“…A previous study explored the clinical relevance of the C-reactive protein-to-albumin (CRP/CAR) ratio for in-hospital mortality in patients with coronavirus disease 2019 (COVID-19) 2 . In this study, the findings revealed that both CRP and CRP/CAR ratio were effective in predicting mortality in elderly COVID-19 patients 1 . However, from our point of view, there are several issues that need to be addressed further in this investigation.…”

“…We read with interest the article entitled “Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients.” 1 . A previous study explored the clinical relevance of the C-reactive protein-to-albumin (CRP/CAR) ratio for in-hospital mortality in patients with coronavirus disease 2019 (COVID-19) 2 .…”

The utility of hemoglobin, albumin, lymphocyte and platelet (HALP) score in predicting mortality among COVID-19 patients: a preliminary study

“…In the presence of nutritional problems, sepsis, severe trauma, malignancy, and severe inflammation, low albumin levels can be observed due to increased vascular permeability [15]. It has been shown that hypoalbuminemia is associated with mortality in critically ill patients [16]. In a study conducted in Italy, the data of 319 COVID-19 patients were examined, and when the patients were divided into survivor and nonsurvivor groups, the nonsurvivor group was determined to have lower albumin levels at the time of admission [17].…”

Relation between Orotracheal Intubation, Inflammatory Markers, Breathing and Voice in Post-COVID-19

“…COVID-19 may lead to oxidative damage thus triggering an intense inflammatory response in the human body, being an extremely complex event 9 . There are some biological markers that determine the inflammatory response from the elevation of its serum levels, among them the C-reactive protein (CRP) and the D-Dimer (DD) 3 , 10 , 11 as an indication of worsening of the COVID-19 condition.…”