SARS-CoV-2 association with hemoglobin and iron metabolism

Mancilha, Elaine Maria Borges; Oliveira, José Salvador Rodrigues de

doi:10.1590/1806-9282.20210555

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…The reduced availability of serum iron results in a low transferrin saturation ratio that affects the Hb synthesis and erythropoiesis (RBCs production), leading to anemia of inflammation [69,71]. This decreased circulation of RBCs perpetuates hypoxemia and prevents tissue oxygenation, which is already difficult in patients with acute COVID-19 respiratory syndrome [72]. In fact, alterations in iron metabolism are associated with hypoxemia in COVID-19 patients [45,73].…”

Section: Anemia and Iron Dysmetabolism In Covid-19mentioning

confidence: 99%

Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects

Russo¹,

Tellone

Barreca

et al. 2022

IJMS

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Several diseases (such as diabetes, cancer, and neurodegenerative disorders) affect the morpho-functional aspects of red blood cells, sometimes altering their normal metabolism. In this review, the hematological changes are evaluated, with particular focus on the morphology and metabolic aspects of erythrocytes. Changes in the functionality of such cells may, in fact, help provide important information about disease severity and progression. The viral infection causes significant damage to the blood cells that are altered in size, rigidity, and distribution width. Lower levels of hemoglobin and anemia have been reported in several studies, and an alteration in the concentration of antioxidant enzymes has been shown to promote a dangerous state of oxidative stress in red blood cells. Patients with severe COVID-19 showed an increase in hematological changes, indicating a progressive worsening as COVID-19 severity progressed. Therefore, monitored hematological alterations in patients with COVID-19 may play an important role in the management of the disease and prevent the risk of a severe course of the disease. Finally, monitored changes in erythrocytes and blood, in general, may be one of the causes of the condition known as Long COVID.

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Section: Anemia and Iron Dysmetabolism In Covid-19mentioning

confidence: 99%

Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects

Russo¹,

Tellone

Barreca

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…1 ). Such manifestations can be observed during the infection of COVID-19, which often disappear after the resolution of the infection [ 22 ]. Due to the rapid spread of the virus, it is necessary to take necessary precautions regarding the risk factors that make these patients more vulnerable to this disease.…”

Section: Covid-19 In Patients With Anemia and Haematological Malignan...mentioning

confidence: 99%

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

Kakavandi,

Hajikhani,

Azizi

et al. 2024

Cell Commun Signal

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Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living with haematological disorders and malignancies (HDMs). Because individuals with moderate to severe immunodeficiency are likely to undergo persistent infections, shed virus particles for prolonged periods, and lack an inflammatory or abortive phase, this represents an overall risk of morbidity and mortality from COVID-19. In cases suffering from HDMs, further investigation is needed to achieve a better understanding of triviruses and a group of related variants in patients with anemia and HDMs, as well as their treatment through vaccines, drugs, and other methods. Against this background, the present study aimed to delineate the relationship between HDMs and the novel COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Besides, effective treatment options for HDM cases were further explored to address this epidemic and its variants. Therefore, learning about how COVID-19 manifests in these patients, along with exploiting the most appropriate treatments, may lead to the development of treatment and care strategies by clinicians and researchers to help patients recover faster.

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“…Because COVID-19 may be to blame for the reduced RBC circulation that maintains hypoxemia and prevents tissue oxygenation, which is already difficult in patients with acute COVID-19 respiratory syndrome, as well as a decrease in HB level that results in anemia, changes in iron metabolism are related to hypoxemia in COVID-19 patients (52,53,54) .…”

Section: Red Blood Cells (Rbcs) and Hemoglobinmentioning

confidence: 99%

Complete Blood Count and saliva parameters as an indicator for infected patients with coronavirus covid-19

et al. 2023

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Background: Coronavirus, which causes respiratory illness, has been a public health issue in recent decades. Because the clinical symptoms of infection are not always specific, it is difficult to expose all suspects to qualitative testing in order to confirm or rule out infection as a test. Methods: According to the scientific studies and investigations, seventy-three results of scientific articles and research were obtained using PubMed, Medline, Research gate and Google Scholar. The research keywords used were COVID-19, coronavirus, blood parameters, and saliva. Results: This review provides a report on the changes in the blood and saliva tests of those who are infected with the COVID-19.COVID-19 is a systemic infection that has a substantial influence on the hematological system and hemostasis, thus deviations from normal levels of laboratory tests, including the blood and saliva test show that specific testing for detecting COVID-19 infection is required. Conclusions: The blood and saliva tests aid in the clinical monitoring of the patient's health. It has advantages such as the following: it has non-invasive properties, low cost, and good stability, addition to minimum risk of infection transport.

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SARS-CoV-2 association with hemoglobin and iron metabolism

Cited by 6 publications

References 23 publications

Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects

Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches

Complete Blood Count and saliva parameters as an indicator for infected patients with coronavirus covid-19

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