Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients

Çelik, Abdullah; Karaaslan, Muhammet Buğra

doi:10.1590/1806-9282.20201127

Cited by 3 publications

(1 citation statement)

References 18 publications

(20 reference statements)

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“…An increased count of pro-inflammatory monocytes and a reduced level of anti-inflammatory HDL cholesterol have been considered novel markers of inflammation. As a result of these studies, the monocyte to HDL cholesterol ratio (MHR) has emerged as a novel marker for determining endothelial injury, inflammation, and oxidative stress [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

Aydin¹,

Eynel²,

Oruç³

et al. 2021

Cureus

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Introduction: Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) has emerged as a novel marker of endothelial injury, inflammation, and oxidative stress. This study aimed to investigate the effect of MHR on primary nephrotic syndrome (NS) and its relationship with the severity of proteinuria.Methods: This study enrolled 161 patients newly diagnosed with primary NS and 100 healthy individuals. Demographic characteristics of the patients, primary NS diagnosis, basal laboratory parameters, the amount of 24-hour urinary protein excretion, and MHR were recorded. The groups were compared regarding these parameters.Results: MHR was significantly higher in patients with primary NS compared with the healthy group (12.89 ± 4.86 and 9.71 ± 2.30, respectively; p < 0.001). There was no difference between the groups in terms of age and sex. The amount of protein in the 24-hour urine in patients with a diagnosis of primary NS was 6.91 ± 3.73 g/day. The correlation analysis showed a positive correlation between MHR and the amount of proteinuria (r = 0.519, p < 0.001) and creatinine level (r = 0.167, p = 0.034). The multivariate regression analysis found that the severity of proteinuria was independently correlated to MHR (p < 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off level for MHR in NS was 10.08 (area under the curve of 0.704, sensitivity of 68%, and a specificity of 62%). Conclusion:Our study is the first to compare the severity of proteinuria and renal functions with MHR in patients with primary NS. We believe that MHR can be used as a biomarker to determine inflammation, endothelial injury, and the level of oxidative stress, and may be useful to predict prognosis in patients with primary NS.

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Section: Introductionmentioning

confidence: 99%

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

Aydin¹,

Eynel²,

Oruç³

et al. 2021

Cureus

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The Predictive Role of Hematological Parameters in Hypertension

Meng

Sun

et al. 2023

Angiology

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Hypertension (HT) is a common chronic disease that often causes target-organ damage and severe complications, contributing to cardiovascular morbidity and mortality worldwide. Accumulating evidence suggests that inflammation plays a prominent role in the initiation and progression of HT. Multiple inflammatory biomarkers have been proposed to predict HT. Several new hematological parameters can reflect the inflammatory response and platelet activation. The major advantage of hematological parameters over conventional inflammatory markers is that they are relatively inexpensive and easily obtained from routine blood tests. Numerous studies have investigated several hematological parameters for their utility as predictive biomarkers for the diagnosis and prognosis of HT. Among them, the neutrophil to lymphocyte ratio (NLR), monocyte to high density lipoprotein cholesterol ratio (MHR), red cell distribution width (RDW), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and systemic immune-inflammation index (SII) have recently received attention. We searched PubMed and Embase databases (up to September 18, 2022) to assess the relationships between hematological parameters and HT. This review discusses the diagnostic and prognostic value of these hematological parameters in HT, providing an important basis for early screening, risk stratification, and optimal management of hypertensive patients.

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Comment on “Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients”

Qiu

Liu

2022

Rev. Assoc. Med. Bras.

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Dear editor,We are pleased to read the article published by Celik and Karaaslan 1 entitled "Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients". The results of this study revealed that the increased monocyte-tohigh-density lipoprotein cholesterol ratio level was associated with hypertension and increased left atrial volume indexes. This study may provide new information on the prevention measure to hypertensive patients with left atrial enlargement. However, according to our opinion, some concerns should be raised.The main concern is that baseline was inconsistent across two groups (Table 1). The monocyte-to-high-density lipoprotein cholesterol ratio may be increased with age. We found that the mean age in hypertension group was higher than that in the control group (53.1 years vs. 44.8 years). Thus, the age may be a confound factor that has an influence on the relationship between monocyte-to-high-density lipoprotein cholesterol

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Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients

Cited by 3 publications

References 18 publications

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome

The Predictive Role of Hematological Parameters in Hypertension

Comment on “Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients”

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