Oxidative Stress of in-Ovo Ochratoxin A Administered during Chick Embryonic Development

Elsayed, Mae; Mohamed, NE; Hatab, M.H.; Elaroussi, M.A.

doi:10.1590/1806-9061-2017-0637

Cited by 10 publications

(7 citation statements)

References 30 publications

(38 reference statements)

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“…After 19 d of incubation, the blood and organ samples exhibited a high degree of thyroid hormone, and liver tissue showed megalocytosis and degeneration of liver cells in OTA injected chicks. These results confirmed that OTA exposure during the embryonic stage would lead to extensive oxidative damage and organ damage ( Elsayed et al., 2019 ). The schematic representation of OTA carryover from feed to various parts of chicken is given in Fig.…”

Section: Contamination Of Ota In the Feed Of Meat-producing Animalssupporting

confidence: 76%

Ochratoxin A: Carryover from animal feed into livestock and the mitigation strategies

et al. 2021

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This review aims to highlight the effects of ochratoxin A (OTA) in the feed of meat-producing animals. The accumulation of OTA in feed and its distribution in various farm animals were compared and evaluated. Primarily, the oral administration of OTA-contaminated feed and the predisposition in an animal's vital organ were critically examined in this work. The collated reports show that OTA directly associated with endemic nephropathy and its high concentration leads to degeneration of liver cells, and necrosis of intestinal and lymphoid tissues. At present, limited reports are available in the recent literature on the problems and consequences of OTA in feed. Therefore, this review focused on the OTA carryover from feed to farm animals and the interaction of its secondary metabolites on their biochemical parameters. Hence, this report provides greater insights into animal health related to OTA residues in meat and meat products. This article also explores mitigation strategies that can be used to prevent the carryover effects of OTA in livestock feeds and the effects in the food chain.

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Section: Contamination Of Ota In the Feed Of Meat-producing Animalssupporting

confidence: 76%

Ochratoxin A: Carryover from animal feed into livestock and the mitigation strategies

et al. 2021

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“…However, blood samples collected in research with CE do not always allow this analysis because it is not easy and takes time. Therefore, alternatives samples have been used to assess these parameters, such as amniotic fluid and allantoic fluid (5,7,46). In this work, we compared the biochemical analyses of serum and allantoic fluid and observed that the values found for the two samples were not always similar.…”

Section: Discussionmentioning

confidence: 97%

Physiological Changes in Chicken Embryos Inoculated With Drugs and Viruses Highlight the Need for More Standardisation of This Animal Model

Sommerfeld

Mundim

Silva

et al. 2021

Preprint

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Background: Several works have been developed using the Gallus gallus embryo as an experimental model to study the toxicity of drugs and infections. Studies that seek to standardise the evaluated parameters are needed to better understand and identify the viability of chicken embryos (CE) as an experimental model. Therefore, we sought to verify whether macroscopic, histopathological, blood count, metabolites and/or enzymes changes and oxidative stress in CE of different ages are peculiar to the model. To achieve this goal, in ovo assays were performed injecting a virus (Gammacoronavirus) and two drugs (filgrastim and dexamethasone) that cause known changes in adult chickens and other animals. Results: Embryo response to virus and drug challenges may not occur as expected for adult chickens and even different species. While macroscopic and microscopic damage was visible in the case of viral infections, the white blood cell count and inflammation biomarkers did not change. Filgrastim (FG) testing did not result in the expected effects for CE. On the other hand, with dexamethasone (DX), changes in blood parameters and biomarkers were inherent to the model and depended on the stage of CE development.Conclusions: Our work reinforces the importance of standardization and correct use of the model so that the results of infection, toxicity and pharmacokinetics are recorded.

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“…However, blood samples collected in research with CE do not always allow this analysis because it is not easy and takes time. Therefore, alternatives samples have been used to assess these parameters, such as amniotic uid and allantoic uid 5,7,33 . In this work, we compared the biochemical analyses of serum and allantoic uid and observed that the values found for the two samples were not always similar.…”

Section: Discussionmentioning

confidence: 99%

Physiological Changes in Chicken Embryos Inoculated with Drugs and Viruses Highlight the Need for More Standardisation of This Animal Model

Sommerfeld

Mundim

Silva

et al. 2021

Preprint

View full text Add to dashboard Cite

Several works have been developed using the Gallus gallus embryo as an experimental model to study the toxicity of drugs and infections. Studies that seek to standardise the evaluated parameters are needed to better understand and identify the viability of chicken embryos (CE) as an experimental model. Therefore, we sought to verify whether macroscopic, histopathological, blood count, metabolites and/or enzymes changes and oxidative stress in CE of different ages are peculiar to the model. To achieve this goal, in ovo assays were performed injecting a virus (Gammacoronavirus) and two drugs (filgrastim and dexamethasone) that cause known changes in adult chickens and other animals. Embryo response to virus and drug challenges may not occur as expected for adult chickens and even different species. While macroscopic and microscopic damage was visible in the case of viral infections, the white blood cell count and inflammation biomarkers did not change. Filgrastim (FG) testing did not result in the expected effects for CE. On the other hand, with dexamethasone (DX), changes in blood parameters and biomarkers were inherent to the model and depended on the stage of CE development. Our work reinforces the importance of standardization and correct use of the model so that the results of infection, toxicity and pharmacokinetics are recorded.

show abstract

Oxidative Stress of in-Ovo Ochratoxin A Administered during Chick Embryonic Development

Cited by 10 publications

References 30 publications

Ochratoxin A: Carryover from animal feed into livestock and the mitigation strategies

Ochratoxin A: Carryover from animal feed into livestock and the mitigation strategies

Physiological Changes in Chicken Embryos Inoculated With Drugs and Viruses Highlight the Need for More Standardisation of This Animal Model

Physiological Changes in Chicken Embryos Inoculated with Drugs and Viruses Highlight the Need for More Standardisation of This Animal Model

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