The growth performances of DZ-white and Improved Horro chickens in three different agro-ecological zones were evaluated in the present study. 861 day-old unsexed chicks were randomly assigned to a 2×3 factorial arrangement in CRD involving two breeds (DZ-white and Improved Horro), three locations (Debre Berhan-L1, MelkaWerer-L2and Mekelle-L3 characterized as highland, lowland and midland respectively). FI, ADG, FCR. BW, BW gain and mortality were measured. Data were analyzed by GLM procedure of SAS .The result revealed that effect of breed on Initial BW,BW, BW gain, ADGFI was significantly (P ≤ 0.05) higher and FCR was significantly (P ≤ 0.05) better for DZ-white breed during the starter and grower phase. Among the locations significantly (P ≤ 0.05) higher BW was recorded on L1 and L3 at both phases. During the starter phase significantly (P ≤ 0.05) higher BW gain and ADG was recorded in the birds kept in L1 and L3. Birds consumed significantly (P ≤ 0.05) more feed on L1 during the starter phase. However, significantly (P ≤ 0.05) more feed were recorded on L1 and L3 during the grower phase and better FCR was recorded in L3 at both phases. Mortality was significantly (P ≤ 0.05) higher on L2at both phases. There was a significant (P ≤ 0.05) breed by location interaction for FI both at starter and grower phase and BW at grower phase. DZ-white exhibited the highest at L1 and L3, followed by DZ-white at L2 and Improved Horro at L3 and the lowest one was recorded for Improved Horro at L1 and L2.DZ-white was significantly (P≤0.05) superior in feed intake at L1 followed by Improved Horro at L1 and significantly (P≤0.05) lower feed intake was recorded in both breeds at L3 during the starter phase. However, DZ-white was significantly superior in feed intake at L1, followed by DZ-white at L3 and significantly (P≤0.05) lower feed intake was recorded in the Improved Horro across the location and DZ-white at L2 during the grower phase. In conclusion, the results of this study have demonstrated that DZ-white breeds had significantly enhanced speed of weight gain as well as growth and good feed conversion ratio. However, this study has also shown that Improved Horro chickens breeds have the genetic ability to grow fast if properly managed. Both chicken breeds are well adapted in highland and midland agro-ecology zone and their production performance was better than the chicken kept in lowland agro-ecology zone.