Prevalence of vitamin D deficiency and its relationship with factors associated with recurrent wheezing

Peçanha, Mirna Brito; Freitas, Rodrigo de Barros; Moreira, Tiago Ricardo; Silva, Luiz Sérgio; Oliveira, Leandro Licursi de; Cardoso, Sílvia Almeida

doi:10.1590/1806-3713/e20170431

Cited by 17 publications

(19 citation statements)

References 20 publications

(27 reference statements)

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“…Preliminary observation of ours indicate insufficient vitamin D levels were found in 60% of adolescents of the city of Salvador, in the Northeast of Brazil of tropical climate with an average yearly temperature of 27 °C and estimated radiation of 5.9 kWh/m 2 [ 49 ]. Similar observations were reported in a population of South-eastern Brazil [ 50 ]. To explore this paradox, we hypothesized that genetic variants in vitamin D pathway genes may affect 25(OH)D levels and then may affect atopy and asthma in the Brazilian population.…”

Section: Introductionsupporting

confidence: 91%

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Galvão

Sena

Belitardo

et al. 2020

Allergy Asthma Clin Immunol

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Background Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels of 25-hydroxyvitamin D (25(OH)D), atopy, asthma and asthma severity in teenagers from Northeast Brazil. Methods This is a cross sectional study nested in a cohort population of asthma. 25(OH)D was quantified from 968 of 11–17 years old individuals by ELISA. Asthma diagnosis was obtained by using the ISAAC Phase III questionnaire. Specific IgE was determined by ImmunoCAP; genotyping was performed using the 2.5 HumanOmni Biochip from Illumina. Statistical analyses were performed in PLINK 1.07 and SPSS 22.1. Results After quality control, 104 Single Nucleotides Variants (SNVs) in vitamin D pathway genes, typed in 792 individuals, were included in the analysis. The allele A of rs10875694 on VDR was positively associated with atopy (OR = 1.35; 95% CI 1.01–1.81). The allele C of rs9279 on VDR , was negatively associated with asthma risk (OR = 0.66; 95% CI 0.45–0.97), vitamin D insufficiency (OR = 0.78; 95% CI 0.70–0.96) and higher VDR expression. Two variants in VDR were associated with asthma severity, the allele A of rs2189480 (OR = 0.34; 95% CI 0.13–0.89) and the allele G of rs4328262 (OR = 3.18; 95% CI 1.09–9.28). The combination of variants in CYP2R1 and CYP24A1 (GAC, to rs10500804, rs12794714 and rs3886163, respectively) was negatively associated with vitamin D production ( β = − 1.24; 95% CI − 2.42 to − 0.06). Conclusions Genetic variants in the vitamin D pathway affect vitamin D serum levels and, thus, atopy and asthma.

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Section: Introductionsupporting

confidence: 91%

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Galvão

Sena

Belitardo

et al. 2020

Allergy Asthma Clin Immunol

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“…In Brazil, information about vitamin D deficiency in healthy children is still scarce. Peçanha et al (2019) reported, in his study of 124 children with recurrent wheezing, a prevalence of vitamin D deficiency/insufficiency of 57.3%. Similar values were found by Peracchi et al (2014) studying children and adolescents with recurrent systemic lupus where the prevalence was 50%, but when compared with a control group, deficiency was found only among 20% of them.…”

Section: -8 Yearsmentioning

confidence: 97%

“…This shows us that such values may have been influenced by the underlying disease. Further studies on vitamin D in healthy children in Brazil are needed to establish an overview of such deficiencies (34,35) .…”

Section: -8 Yearsmentioning

confidence: 99%

Definition of Vitamin D Deficiency in Schoolchildren: Systematic Review With Meta-Analysis

Linden

Freitas

Hessel

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Vitamin D deficiency is being recognized as a pandemic due to the volume of people affected by the deficiency and the number of illnesses generated or stimulated by the deficiency. There is a lack of consensus in the literature on what is considered vitamin D deficiency [25(OH)D]. OBJECTIVE: This review brings together the most common levels of 25(OH)D found in healthy schoolchildren and what is considered deficient. METHODS: This systematic review was based on the literature accessed from the electronic databases: MEDLINE, EMBASE, LILACS, SCOPUS and WEB OF SCIENCE. The following descriptors were used in English, Portuguese and Spanish: “Vitamin D”; “Vitamin D deficiency”; “Nutritional Supplements” as well as all their synonyms. The meta-analysis was performed considering the random model. Inclusion criteria: healthy children aged 6 to 12 years, studies that had vitamin D levels, defined vitamin D deficiency. RESULTS: Of the 191 potentially eligible articles, only six articles were included, with 2618 students in total. The mean value of 25(OH)D was estimated at 18.11 ng/mL with 95% confidence interval. Among the articles found, three were considered deficiency levels below 20 ng/mL, one considered below 18 ng/mL, another below 15 ng/mL, and the latter below 11 ng/ mL. The prevalence of vitamin D deficiency among the articles was 48.6%, 7%, 98%, 64.63%, 19.5%, 28.4%, according to each classification used by the same. CONCLUSION: The most common definition in the literature of 25(OH)D deficiency in schoolchildren was at levels below 20 ng/mL. No side effects have been reported in studies that used fortification and/or vitamin D supplementation. Daily supplementation is more effective than seasonal supplementation. However, more studies are needed to define what can be considered as optimal levels of 25(OH)D in children.

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“…In an earlier study, a significantly lower mean 25(OH)D level was observed in patients with RW than in a healthy control group, and the level was negatively correlated with the duration of wheezing, number of wheezing episodes and systemic glucocorticoid need (34). Conversely, Pecanha and colleagues showed no association between 25(OH)D concentration and exacerbations, as assessed on the basis of hospitalizations, emergency department (ED) visits, and oral corticosteroid use in children with RW, but observed an association with onset of wheezing before the age of 1 year (35).…”

Section: Relationship Between Vitamin D Deficiency and Wheezing And/omentioning

confidence: 97%

The Role of Vitamin D Deficiency in Children With Recurrent Wheezing—Clinical Significance

et al. 2020

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Recurrent wheezing (RW) in infancy is one of the most frequent reasons for parents to consult health care providers and creates a significant global burden. Clinical course of RW is difficult to predict, also which infants will progress to asthma, since no valid biomarkers have been established. Identification of those infants with RW who are at risk of further recurrences and/or severe acute respiratory tract infection (ARTI) could help pediatricians to improve their therapeutic decisions. Increasing research interest is focused on the extra-skeletal actions of vitamin D (VD) and the clinical impact of VD insufficiency/deficiency. As VD deficiency could be a risk factor for causing RW in children, measurement of their serum level of 25-hydroxycholecalciferol [25(OH)D] is recommended. In the case of deficiency, VD administration is recommended in age-appropriate doses for at least 6 weeks, until achievement of normal blood 25(OH)D level, followed by supplementation as long as exposure to sun is inadequate. Higher doses of VD given in an attempt to prevent asthma development appear to be of no additional benefit. In children with severe ARTI, VD level is recommended to be assess.

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Prevalence of vitamin D deficiency and its relationship with factors associated with recurrent wheezing

Cited by 17 publications

References 20 publications

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Definition of Vitamin D Deficiency in Schoolchildren: Systematic Review With Meta-Analysis

The Role of Vitamin D Deficiency in Children With Recurrent Wheezing—Clinical Significance

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