The effect of kefir consumption on the lipid profile for individuals with normal and dyslipidemic properties: a randomized controlled trial

Abstract

Objective This research was conducted as a prospective, self-controlled, eight-week clinical trial to investigate the effect of kefir consumption on the lipid profile of individuals with normal and dyslipidemic properties. Methods Kefir microorganisms given to volunteer subjects were determined using classical microbial count methods and qReal-Time Polymerase Chain Reaction. The study was carried out with 23 volunteer hospital health personnel between the ages of 20 and 55 who met the research criteria and did not have any health problems. The volunteers regularly consumed kefir on an empty stomach for four weeks. In the last stage, the eight-week study was completed by making blood and anthropometric measurements of the subjects, who continued to be studied without kefir consumption for four more weeks. Results Considering the changes in the serum lipid profiles of 13 individuals with dyslipidemic symptoms during the 4-week period they consumed kefir, Total Cholesterol values decreased by 9.15% compared to initial values, LDL-Cholesterol values decreased by 10.64%, HDL-Cholesterol values decreased by 6.9%, and triglyceride values decreased by 2.46%. The changes in the serum lipid profiles of 13 individuals with dyslipidemic findings at the end of an eight-week study were a 5.71% decrease in total cholesterol values (p<0.018) considered statistically significant, as well as a 5.31% decrease in LDL-Cholesterol values (p<0.021); the HDL-Cholesterol results were found to be significant with an 8.58% decrease in the values (p<0.035) and insignificant with a 17.21% increase in the triglyceride values (p<0.926). We concluded that regular kefir consumption was effective in both women and men in lowering total cholesterol and LDL-Cholesterol from blood lipid profiles, especially in individuals with dyslipidemic symptoms, while this effect was not observed in normal individuals. Conclusion Kefir can positively affect the total cholesterol and LDL-Cholesterol blood parameters of dyslipidemic individuals with high serum lipid values.

The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review

“…However, Ghizi et al showed a decrease in serum LDL and triglycerides with kefir versus placebo in patients with metabolic syndrome, and an increase in serum high-density lipoprotein (HDL) was only observed in females [72]. Similarly, in a study including both patients with dyslipidemia and patients with normal lipid profiles, only patients with dyslipidemia displayed decreases in serum lipid concentrations, but this study did not involve a placebo group [73]. Comparable to the reported effects of kefir on immune outcomes in clinical studies, metabolic outcomes appear to be affected by host characteristics such as disease status and gender.…”

The potential preventive effect of probiotics, prebiotics, and synbiotics on cardiovascular risk factors through modulation of gut microbiota: A review

“…Previous studies have indicated that the strains of Bifidobacteria and Lactobacillus have been associated with a notable reduction in serum cholesterol levels (Rubin et al., 2022 ). The regular consumption of kefir has been shown to have a positive impact on reducing total cholesterol and LDL‐cholesterol levels in blood lipid profiles, particularly in individuals experiencing dyslipidemic symptoms (Yilmaz & Arslan, 2022 ).…”