“…Although some studies have evaluated the potential of irrigation solutions (12,14,(16)(17)(18), others have assessed the potency of different devices such as instrumentation along with an irrigation solution (19), endodontic brushes (20), nickel-titanium rotary instruments (21), apical negative pressure (ANP) irrigation using the EndoVac system and a Self-Adjusting File (SAF) (ReDent-Nova, Ra'anana, Israel) (22), the RinsEndo system (D€ urr Dental, Bietigheim, Germany) (23), laser-activated irrigation (24,25), and sonically and ultrasonically activated irrigation (26,27). Many studies have found that it is difficult to remove Ca(OH) 2 from the apical third of the root canal system (20,23,(28)(29)(30)(31). However, a narrative review reported that ultrasonically activated irrigation seems to be more effective for the removal of Ca(OH) 2 than other techniques (32).…”