Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial

Abstract

Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial* Objective: Our study compared the effects of injectable platelet-rich fibrin (i-PRF) with those of corticosteroids in the treatment of erosive oral lichen planus (EOLP). Methodology: This split-mouth study included 24 individuals diagnosed histopathologically with bilateral EOLP. One bilateral lesion was injected with i-PRF, whereas the other was injected with methylprednisolone acetate in four sessions at 15-day intervals. Visual analog scale (VAS) for pain and satisfaction, oral health impact profile scale-14, and the lesion size were used. Results: The intragroup comparisons showed a significant decrease in VAS-pain and lesion size in both the i-PRF group (from 81.88±17.74 to 13.33±18.34, and from 4.79±0.41 to 1.88±1.08, respectively) and the corticosteroid group (from 80.21±17.35 to 23.33±26.81, and from 4.71±0.46 to 2.21±1.35, respectively) in the 6th month compared to baseline (p<0.001). Moreover, VAS-satisfaction increased significantly in both the i-PRF group (from 26.67±17.8 to 85.63±16.24) and the corticosteroid group (from 28.33±17.05 to 74.38±24.11) in the 6th month compared to baseline (p<0.001). However, no significant difference in any value occurred in the intergroup comparisons. Conclusion: In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. Therefore, the use of i-PRF may be considered an option in cases refractory to topical corticosteroid therapy. Biochemical and histopathological studies are required to reveal the mechanism of i-PRF action in EOLP treatment.

Current dental approaches in autoimmune bullous diseases

“…It has been shown that i-PRF can be as effective as corticosteroid injection, which is considered the gold standard in the treatment of EOLP lesions. 83 There is no clinical study involving i-PRF application in oral lesions of autoimmune bullous diseases.…”

Platelet-rich fibrin and its use in dentistry

“…Besides, recent research demonstrated that i-PRF has a positive and curative effect on erosive lichen planus (30). In another study, Johns et al (36) documented that pulp revascularization shows disinfection with photodynamic therapy combined with platelet-rich fibrin leads to satisfactory root development in necrotic immature teeth.…”

Ten years of injectable platelet‐rich fibrin

“…26 Two further studies demonstrated that i-PRF injections significantly improved symptomatic oral lichen planus. 27,28 In a final clinical study, Negah and colleagues investigated i-PRF administration for the management of root resorption in 10 healthy patients. 29 It was reported that the clinical evaluation resulted in the resolution of signs and symptoms through a 12-month follow-up period in all cases.…”

“…In a clinical study by Kiziltoprak and colleagues, higher palatal wound epithelialization and lower bleeding and pain scores were found in the i‐PRF group than in the control group 26 . Two further studies demonstrated that i‐PRF injections significantly improved symptomatic oral lichen planus 27,28 . In a final clinical study, Negah and colleagues investigated i‐PRF administration for the management of root resorption in 10 healthy patients 29 .…”