Bone marrow cytological evaluation in dogs with chronic kidney disease

Abstract

Since anemia is indicated as an important compromising factor for the quality of life of dogs with chronic kidney disease (CKD), bone marrow cytological analysis may provide more information on the hematological profile these dogs and, therefore, allow clinicians to not only choose the most adequate treatment but also monitor the response to therapy. The aim of this study was to investigate the feasibility with sternal bone marrow puncture in chronic kidney disease (CKD) using only local anesthesia and check if the cytological analysis is helpful to determine the hematological status. We found that erythroid hypoplasia occurred only in terminal CKD patients, and that the bone marrows of dogs with CKD stages 2 and 3 were quantitatively similar to those of elderly dogs. All dogs tolerated the bone marrow puncture using only local anesthesia with lidocaine and bone marrow cytological evaluation may be a useful tool for hematopoietic evaluation of anemic dogs with CKD.Keywords: dog, anemia, myelogram, erythropoiesis, renal failure RESUMO Sendo a anemia apontada como um importante fator comprometedor da qualidade de vida dos cães portadores de doença renal crônica (DRC), a análise citológica da medula óssea poderia fornecer mais informações acerca do perfil hematológico desses animais

Persistent nonregenerative anemia in a 4‐year‐old cat

“…In one study, dogs with stage 2 CKD (serum Cr 1.75 ± 0.18 mg/dL) had mild anemia (40.99 ± 7.80%) compared with the control group (50.48 ± 4.36%), and mild hypocellularity was observed on examination of the bone marrow. Conversely, dogs with stage 4 CKD (serum Cr 7.33 ± 2.58 mg/dL) exhibited moderate anemia (28.87 ± 5.83%) and erythroid hypoplasia 19 . Another study reported anemia in only six of 26 cats with stage 2 CKD (blood Cr of 1.7‐2.5 mg/dL).…”