The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease

Geraldes, Silvano Salgueiro; Sueur, André Nanny Vieira Le; Sant’Ana, Paula Bilbau; Azevedo, Maria Gabriela Picelli de; Takahira, Regina Kiomi; Melchert, Alessandra; Lourenço, Maria Lúcia Gomes; Mamprim, Maria Jaqueline; Guimarães-Okamoto, Priscylla Tatiana Chalfun

doi:10.1016/j.tcam.2019.100389

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Serum concentration of urea, creatinine, albumin, potassium and phosphorus were performed in a Cobas Mira Plus Roche enzyme measurement device according to the manufacturers and commercially available kits’ specifications (Bioclin®, Roche Diagnostic, Belo Horizonte, Minas Gerais, Brazil) [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

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C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

Azevedo

Geraldes

Sant’Anna³

et al. 2022

PLoS ONE

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In chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests’ evaluation (CI = 0.59–0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals.

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Section: Methodsmentioning

confidence: 99%

“…Urine was aseptically collected by cystocentesis in the first and last-moments, and urine protein to creatinine ratio was determined by colorimetric method (Bioclin®, Roche Diagnostic, Rotkreuz, Switzerland) [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

Azevedo

Geraldes

Sant’Anna³

et al. 2022

PLoS ONE

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“…Hemodialysis is the most common treatment, routinely performed three times a week at a hemodialysis center [ 33 ]. For commercial hemodialysis, blood is removed through a dialysis catheter located in the right atrium or superior vena cava, externally filtered, and then re-supplied to the blood through the same catheter [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

A Closed-Loop Autologous Erythrocyte-Mediated Delivery Platform for Diabetic Nephropathy Therapy

Feng

Huang

et al. 2022

Nanomaterials

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Failure to control blood glucose level (BGL) may aggravate oxidative stress and contribute to the development of diabetic nephropathy (DN). Using erythrocytes (ERs) as the carriers, a smart self-regulatory insulin (INS) release system was constructed to release INS according to changes in BGLs to improve patients’ compliance and health. To overcome the limited sources of ERs and decrease the risk of transmitting infections, we developed an in vitro, closed-loop autologous ER-mediated delivery (CAER) platform, based on a commercial hemodialysis instrument modified with a glucose-responsive ER-based INS delivery system (GOx-INS@ER). After the blood was drained via a jugular vein cannula, some of the blood was pumped into the CAER platform. The INS was packed inside the autologous ERs in the INS reactor, and then their surface was modified with glucose oxidase (GOx), which acts as a glucose-activated switch. In vivo, the CAER platform showed that the BGL responsively controlled INS release in order to control hyperglycemia and maintain the BGL in the normal range for up to 3 days; plus, there was good glycemic control without the added burden of hemodialysis in DN rabbits. These results demonstrate that this closed-loop extracorporeal hemodialysis platform provides a practical approach for improving diabetes management in DN patients.

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The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease

Cited by 2 publications

References 15 publications

C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

A Closed-Loop Autologous Erythrocyte-Mediated Delivery Platform for Diabetic Nephropathy Therapy

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