Metastatic well differentiated squamous cell carcinoma in the prepuce of a dog: a report of clinicopathological, immunophenotypic and therapeutic approach

Abstract

Palavras-chave: metástase, tumor, pele, imuno-histoquímica, quimioterapia

Electrochemotherapy induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinoma

“…In general, the high Ki67 expression observed in SCC, especially in poorly differentiated SCC, is related to an aggressive phenotype 9,36,39,57 . However, in the lesions studied, the proliferation index was considered high despite the predominance of well-differentiated SCCs (83.3%), suggesting an aggressive phenotype despite the high degree of differentiation.…”

“…In this context, Auler et al . 57 reported a case of a dog with well-differentiated SCC in its foreskin with inguinal lymph node metastasis. This animal showed high Ki67 positivity in the tumor tissue as well as high expression levels of the growth factors HER-2 and epidermal growth factor receptor (EGFR).…”

Electrochemotherapy with bleomycin associated with doxorubicin induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinomas

“…Because ECT is a recent technique in Veterinary Medicine, a limited number of studies have demonstrated the ECT antitumoral effect in cSCC. In general, the high expression level of Ki67 observed in SCC, especially in poorly differentiated SCC, is related to an aggressive potential [9,34,37,49]. However, in the lesions studied, the proliferation index could also be considered high despite the predominance of well-differentiated SCC (83.3%), suggesting the aggressive potential, despite the degree of differentiation.…”

“…It should be noted that the complete evaluation of proliferation markers may be more effective in predicting the biological behavior of the tumor. In this context, Auler et al [49] reported the case of a dog with well-differentiated SCC in the foreskin with inguinal lymph node metastasis. This animal showed high Ki67 positivity in the tumor tissue, in addition to the high expression of the growth factors HER-2 and EGFR (epidermal growth factor receptor).…”

Tubular adenocarcinoma with squamous differentiation areas in a feline foreskin (Felis catus): A report of clinical-surgical, pathological, and therapeutic approach

“…However, there are reports of adenocarcinoma affecting the feline mammary glands (Amorim et al, 2004), intestine (Queiroz et al, 2017), apocrine/salivary glands (Fujiwara-Igarashi et al, 2017), prostate (Tursi et al, 2008), and uterus (Saraiva et al, 2015). In addition, there are also reports of neoplasms affecting the foreskin of dogs (Yaghoobi Yeganeh Manesh et al, 2014;Auler et al, 2014) and horses (Chacur et al, 2014).…”