mcr-1-carrying Enterobacteriaceae isolated from companion animals in Brazil

Kobs, Vanessa Cristine; Valdez, Rafael E.; Medeiros, Francielle de; Fernandes, Patrícia P; Deglmann, Roseneide Campos; Gern, Regina Maria Miranda; França, Paulo Henrique Condeixa de

doi:10.1590/1678-5150-pvb-6635

Cited by 6 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Colistin-resistance genes have also recently been detected in dogs in South Korea [ 23 ]. Further studies have assessed the occurrence of mcr-1 and mcr-2 producing Enterobacteriaceae in cats and other companion animals in Switzerland as well as other countries [ 24 , 43 , 44 , 45 , 46 , 47 ]. For the first time in France, we reported colistin-resistant bacteria carrying mcr genes in pets, although we cannot state if colistin resistance comes from contact with humans, food contamination, illegal colistin use, or environmental factors.…”

Section: Resultsmentioning

confidence: 99%

Screening of Colistin-Resistant Bacteria in Domestic Pets from France

Hamame

Davoust

Rolain

et al. 2022

Animals

View full text Add to dashboard Cite

Background: Pets are the closest animals to humans with a considerable risk of zoonotic transmission. This study aimed to screen colistin-resistant bacteria from stools of dogs and cats from Marseille, France. Screening of mcr genes in pets has never been reported in France. Methods: Fecal samples (n = 157) were cultivated on the selective Lucie-Bardet Jean-Marc-Rolain medium (LBJMR). Bacteria were identified using Microflex LS MALDI-TOF. The antibiotic resistance phenotype was investigated for several antibiotics (β-lactams, aminoside, cephalosporine, tetracycline, and sulfonamide). PCR techniques were performed to detect mcr genes. Results: A total of 218 bacteria were identified. For cats, intrinsically colistin-resistant bacteria were significantly higher than mcr-1 gene carriers (n = 4). Dogs had more bacteria with the mcr-1 gene (n = 10). Furthermore, cats had a high prevalence of Gram-positive bacteria (GPB), whereas dogs had GNB equal to GPB. The diversity of identified bacteria was due to the constitution of the pets’ microorganisms. Even though colistin use is monitored in France, pets harbor various colistin-resistant bacteria. Additionally, in this geographical area, bacteria bearing mcr-1 gene from dogs and cats were detected for the first time. Conclusions: The current study opens a new perspective: the spread of colistin resistance is independent of colistin use. What are the most factors related to the emergence of colistin resistance? The surveillance of pets must be considered a priority to avoid the spread of mcr genes. It is important to know the contribution that pets make to the pool of multidrug-resistant mcr-1-containing bacteria.

show abstract

Section: Resultsmentioning

confidence: 99%

Screening of Colistin-Resistant Bacteria in Domestic Pets from France

Hamame

Davoust

Rolain

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…In 2020, a Brazilian study described the isolation of mcr-1-positive E. coli, Enterobacter sp., and Klebsiella sp. from clinical samples [93]. Furthermore, mcr-1 and mcr-3.7 were detected in a single E. coli ST132 isolated from a fecal sample in China.…”

Section: Mcr Genes In Dogsmentioning

confidence: 92%

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

et al. 2022

View full text Add to dashboard Cite

Background: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through mcr genes in pets. The current study also highlights the health risks of the transmission of colistin resistance between pets and humans. Methods: We conducted a systematic review on mcr-positive bacteria in pets and studies reporting their zoonotic transmission to humans. Bibliographic research queries were performed on the following databases: Google Scholar, PubMed, Scopus, Microsoft Academic, and Web of Science. Articles of interest were selected using the PRISMA guideline principles. Results: The analyzed articles from the investigated databases described the presence of mcr gene variants in pets including mcr-1, mcr-2, mcr-3, mcr-4, mcr-5, mcr-8, mcr-9, and mcr-10. Among these articles, four studies reported potential zoonotic transmission of mcr genes between pets and humans. The epidemiological analysis revealed that dogs and cats can be colonized by mcr genes that are beginning to spread in different countries worldwide. Overall, reported articles on this subject highlight the high risk of zoonotic transmission of colistin resistance genes between pets and their owners. Conclusions: This review demonstrated the spread of mcr genes in pets and their transmission to humans, indicating the need for further measures to control this significant threat to public health. Therefore, we suggest here some strategies against this threat such as avoiding zoonotic transmission.

show abstract

“…A study conducted by Kobs et al [ 85 ], demonstrated the presence of the polymyxin resistance gene in pets from the Brazilian state of Santa Catarina. In his analysis, this study identified the first E. coli , Klebsiella spp., and Enterobacter spp.…”

Section: Incidence Of the Mcr Gene In Animal And A...mentioning

confidence: 99%

Gram-negative bacilli carrying mcr gene in Brazil: a pathogen on the rise

et al. 2023

View full text Add to dashboard Cite

The incidence of infections caused by resistant Gram-negative pathogens has become a critical factor in public health due to the limitation of therapeutic options for the control of infections caused, especially, by Enterobacteriaceae ( Escherichia coli and Klebsiella pneumoniae ), Pseudomonas spp., and Acinetobacter spp. Thus, given the increase in resistant pathogens and the reduction of therapeutic options, polymyxins were reintroduced into the clinic. As the last treatment option, polymyxins were regarded as the therapeutic key, since they were one of the few classes of antimicrobials that had activity against multidrug-resistant Gram-negative bacilli. Nonetheless, over the years, the frequent use of this antimicrobial has led to reports of resistance cases. In 2015, mcr ( mobile colistin resistanc e), a colistin resistance gene, was described in China. Due to its location on carrier plasmids, this gene is characterized by rapid spread through conjugation. It has thus been classified as a rising threat to public health worldwide. In conclusion, based on several reports that show the emergence of mcr in different regional and climatic contexts and species of isolates, this work aims to review the literature on the incidence of the mcr gene in Brazil in different regions, types of samples identified, species of isolates, and type of carrier plasmid.

show abstract

mcr-1-carrying Enterobacteriaceae isolated from companion animals in Brazil

Cited by 6 publications

References 19 publications

Screening of Colistin-Resistant Bacteria in Domestic Pets from France

Screening of Colistin-Resistant Bacteria in Domestic Pets from France

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

Gram-negative bacilli carrying mcr gene in Brazil: a pathogen on the rise

Contact Info

Product

Resources

About