Economic losses due to Vernonia rubricaulis poisoning in cattle

Soares, Marcelo Cezar; Pupin, Rayane C.; Guizelini, Carolina C.; Gaspar, Alberto O.; Gomes, Danilo Carloto; Brumatti, Ricardo Carneiro; Lemos, Ricardo A.A.

doi:10.1590/1678-5150-pvb-6075

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…In horses, this glycoside causes severe hepatocellular necrosis (Hill et al 1985, Bandarra et al 2010, Lorenzett et al 2017. Some plants also cause acute liver necrosis, such as Cestrum axillare, Cestrum parqui, Cestrum corymbosum, Cestrum intermedium, Sessea brasiliensis, Vernonia mollissima, Vernonia rubricaulis, Xanthium sp., and Dodonaea viscosa (Riet-Correa et al 1986, Chaulet et al 1990, Gava et al 1991, Marinho et al 2018, Soares et al 2018, Barbosa et al 2020, Pohl et al 2021, Zamboni et al 2021). These plants were not found on the property, allowing excluding them from the diagnosis, demonstrating the importance of an effective epidemiological study in these cases.…”

Section: Discussionmentioning

confidence: 99%

Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

et al. 2022

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Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats and edema and cerebral hemorrhage in horses. This plant can cause toxic pneumopathy in sheep, and there is only one report of the natural form and one of the experimental form in the State of Rio Grande do Sul. This study aimed to report an outbreak of the respiratory form of natural poisoning by T. micrantha in sheep. Six sheep developed clinical respiratory signs after consumption of the plant and four of them died and two recovered after treatment with dexamethasone. The sheep presented tachypnea, noisy breathing, edema of the face, eyelids, and vulva, and subcutaneous emphysema on the face and neck. Necropsy (Sheep 2, 3, and 4) showed uncollapsed, heavy, diffuse red lungs with evident costal impressions and a moderate amount of serosanguineous fluid flowed at section. The liver had a moderate diffuse evident lobular pattern. The histopathology of the lungs of the three necropsied sheep showed congestion and edema with the formation of hyaline membranes within accentuated diffuse alveoli, in addition to thickening of the alveolar septa due to mild to moderate diffuse type II pneumocyte hyperplasia and also mild to moderate diffuse infiltrate of macrophages, lymphocytes, plasma cells, and neutrophils in the lumen of alveoli, bronchi, and bronchioles. Sheep 3 also showed type II pneumocytes with enlarged and hyperchromatic nuclei, sometimes binucleated with evident nucleoli, and, in some regions, the pneumocytes were desquamated to the alveolar lumen forming small syncytia and mild multifocal hyperplasia in the bronchial epithelium. The anti-cytokeratin IHC evaluation showed marked diffuse intracytoplasmic staining in hyperplastic type II pneumocytes in the bronchiolar epithelium of the three evaluated sheep. The liver of the three sheep had mild multifocal centrilobular necrosis. It seems to be the second report of spontaneous poisoning by T. micrantha in sheep developing lung lesions described in Brazil and the first in the State of Santa Catarina.

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Section: Discussionmentioning

confidence: 99%

Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

et al. 2022

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“…The remaining cases occurred in cattle over one year old and in seven farms in the form of large outbreaks affecting 17-200 cattle. Epidemiological data and information on the economic impact caused by this type of plant poisoning are available (Soares et al 2018b).…”

Section: Discussionmentioning

confidence: 99%

Cattle diseases in Mato Grosso do Sul, Brazil: a 24-year survey (1995-2018)

et al. 2019

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We reviewed the records of 5,083 cattle necropsies performed from January 1995 to December 2018 and filed at the Laboratory of Anatomic Pathology (LAP) of the “Universidade Federal de Mato Grosso do Sul” (UFMS). These necropsies were performed either by LAP-UFMS faculty (22.33%) or by field veterinary practitioners (77.67%) who subsequently submitted material for histological evaluation at the LAP-UFMS. Conclusive diagnoses were reached in 46.21% of the protocols (2,349 cases), and approximately 65% of the cases were classified as inflammatory or parasitic diseases, with rabies being the most diagnosed disease (20.82% of total conclusive diagnosis). There were a large number of protocols in which the diagnosis was of nonsuppurative meningoencephalitis of unknown cause (NSMUC). Those were the main differentials for rabies and bovine herpesvirus-5 necrotizing meningoencephalitis (NME); that is, the number of rabies cases may be even higher if one considers that many cases of NSMUC might be undiagnosed rabies cases. Toxic and toxic-infectious diseases were the second most prevalent category, and botulism cases represented 41% of this category. The other categories corresponded to less than 20% of the total diagnoses and were distributed in decreasing order of frequency as degenerative diseases (9.79%), diseases caused by physical agents (3.87%), other diseases (2.13%), neoplasms and tumor-like lesions (1.79%), metabolic or nutritional disorders (1.75%) and congenital malformations (0.64%). The large number of inconclusive diagnoses was mainly due to improper conditions of mailed-in material for histopathological evaluation, namely, nonrepresentative samples of all organs, autolysis, and the absence of epidemiological and clinical-pathological information.

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“…The data provided by several investigations demonstrate than an important number of herbs and herbal products have been implicated in poisoning [44], health problems [45], and alterations in embryonic/fetal development in humans [46] and animals [47]. This latter toxic effect of plants comprises an important problem worldwide, not only for public health, where birth defects are one of the main preventable causes of morbidity, mortality, and childhood disability [48], but also in the economic sector, since in different parts of the world, the consumption of teratogenic plants by pregnant females produces a wide variety of congenital anomalies in livestock, generating, in this manner, considerable losses of capital for companies and local ranchers [49].…”

Section: The Teratogenic Effects Of Mexican Plantsmentioning

confidence: 99%

A Complete Review of Mexican Plants with Teratogenic Effects

Chamorro-Cevallos

Mojica-Villegas

García-Martínez

et al. 2022

Plants

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In Mexico, the use of medicinal plants is the first alternative to treat the diseases of the most economically vulnerable population. Therefore, this review offers a list of Mexican plants (native and introduced) with teratogenic effects and describes their main alterations, teratogenic compounds, and the models and doses used. Our results identified 63 species with teratogenic effects (19 native) and the main alterations that were found in the nervous system and axial skeleton, induced by compounds such as alkaloids, terpenes, and flavonoids. Additionally, a group of hallucinogenic plants rich in alkaloids employed by indigenous groups without teratogenic studies were identified. Our conclusion shows that several of the identified species are employed in Mexican traditional medicine and that the teratogenic species most distributed in Mexico are Astragalus mollissimus, Astragalus lentiginosus, and Lupinus formosus. Considering the total number of plants in Mexico (≈29,000 total vascular plants), to date, existing research in the area shows that Mexican plants with teratogenic effects represent ≈0.22% of the total species of these in the country. This indicates a clear need to intensify the evaluation of the teratogenic effect of Mexican plants.

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Economic losses due to Vernonia rubricaulis poisoning in cattle

Cited by 7 publications

References 19 publications

Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

Cattle diseases in Mato Grosso do Sul, Brazil: a 24-year survey (1995-2018)

A Complete Review of Mexican Plants with Teratogenic Effects

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