Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion

Anselmo, Natassia Alberici; Paskakulis, Leticia Colombo; Garcias, Renata Correia; Botelho, Fernanda Fortuci Resende; Toledo, Giovana Queda; Cury, Maria Fernanda Ribeiro; Carvalho, Natiele Zanardo; Mendes, Glória Elisa Florido; Iembo, Tatiane; Bizotto, Thaís Santana Gastardelo; Cury, Patrí­cia Maluf; Chies, Agnaldo Bruno; Carlos, Carla Patrícia

doi:10.1590/1678-46a85-jbn-3819

Cited by 10 publications

(16 citation statements)

References 41 publications

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“…Male Wistar rats were divided into six groups [n: six per group: (1) control, (2) 75 mg of Brazil nut (BN), (3) 150 mg BN, (4) ischemia-reperfusion (IR), (5) IR with 75 mg BN, and (6) IR with 150 mg BN and submitted to BN daily seven days prior to surgery for IR, with animals sacrificed 48 h thereafter. Reduced oxidative stress-including elevated expression of inducible nitric oxide synthase (iNOS), nitrotyrosine renal expression, and plasma thiobarbituric acid reactive substances (TBARS), was observed in mice pretreated with BN (similar results with both doses) [19]. Male mice C57BL/6J fed either a common feed or fat-rich diet (45% or 21.5% energy from walnuts) for six weeks showed a decrease in MAPK changes and a reduction in lipid peroxidation [20].…”

Section: Studies In Animal Modelsmentioning

confidence: 85%

“…Nutrients show antioxidant activities, especially vitamin E and phenolic compounds [9], with nuts standing out as a source of both [10]. In vitro studies [11][12][13][14][15][16][17][18], animal models [19][20][21][22][23][24], observational studies [25], and randomized trials [26][27][28][29][30][31][32] suggest the potential benefit of including different nuts in the diet to improve biomarkers of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Santos¹,

Quadros²,

Weschenfelder³

et al. 2020

Nutrients

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Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants—like polyphenols and vitamin E—on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-κB and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease.

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Section: Studies In Animal Modelsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Santos¹,

Quadros²,

Weschenfelder³

et al. 2020

Nutrients

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“…Hart, et al repeated [9] the free-low control conditions (FF) and reactive hyperemia (RH) trials under hyperoxic conditions (FF + 100% O 2 and RH + 100% O 2 ) in skeletal gastrocnemius muscle of patients with peripheral artery disease. Anselmo, et al attenuated [10] IR-induced renal changes, with reduction of plasmatic phosphorus as well as reducing kidney expression of iNOS, nitrotyrosine and macrophage in lux after pretreatment with 75 mg of Brazil nuts. Tarui, et al evaluated [11] the outcome and risk factors related [11] with increased creatinine phosphorus kinase in patients undergoing minimally invasive cardiac operation in mitral valve problem.…”

Section: Discussionmentioning

confidence: 99%

The alterations effects in phosphorus of erythropoietin and U-74389G

Τsompos¹,

Panoulis²,

Triantafyllou³

et al. 2020

Int J Bone Marrow Res

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Aim: This study calculated the eff ects on serum phosphorus (P) levels, after treatment with either of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain infl uence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment. Materials and methods:The 2 main experimental endpoints at which the serum P levels were evaluated was the 60 th reperfusion min (for the groups A, C and E) and the 120 th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, the groups C and D after Epo administration; whereas the groups E and F after the L administration. Results:The fi rst preliminary study of Epo presented a non signifi cant hyperphosphoremic eff ect by 2.46% + 2.02% (pvalue = 0.2168). However, the second preliminary study of U-74389G presented a non signifi cant hypophosphoremic eff ect by 1.09% + 2.01% (pvalue = 0.5771). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that L is at least 0.4455128-fold [0.4445589 -0.4464687] more hypophosphoremic than Epo (pvalue = 0.0000). Conclusion:The anti-oxidant capacities of U-74389G ascribe at least 0.4455128-fold [0.4445589 -0.4464687] more eff ects than Epo (pvalue = 0.0000).The alterations effects in phosphorus of erythropoietin and U-74389G https://www.heighpubs.org/hbmr https://doi.

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“…The IR procedure consisted of right nephrectomy and occlusion of the left renal artery with a non-traumatic vascular clamp for 30 min under anesthesia (xylazine 10 mg/Kg + ketamine 85 mg/Kg). 12 - 14 …”

Section: Methodsmentioning

confidence: 99%

“…Twenty-five fields of the renal juxtamedullary region were evaluated in one slide from each animal to obtain an average of the scores performed as previously described. 14 - 16 …”

Section: Methodsmentioning

confidence: 99%

Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion

et al. 2018

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Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion

Abstract: Low intake of BN prior to IR-induced kidney injury improves renal function by inhibition of macrophage infiltration and oxidative stress.

Cited by 10 publications

References 41 publications

Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

The alterations effects in phosphorus of erythropoietin and U-74389G

Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion

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