Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study

Esgalhado, Marta; Stockler‐Pinto, Milena Barcza; Cardozo, Ludmila F M F; Barboza, Jorge; Mafra, Denise

doi:10.1590/1678-4685-jbn-3802

Cited by 3 publications

(1 citation statement)

References 31 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data were also confirmed by Nygaard et al (2015), which further showed that single sessions of intense endurance exercise and heavy strength training led to transient increase of plasma concentration, without an increase in FNDC5 expression (Pang et al, 2018). However, on the other hand, a pivot study in hemo-dyalised patients proved that there was no correlation between intense intra-dialytic strength exercise and the increase of circulating irisin (Esgalhado et al, 2018). Also, the research group of Biniaminov et al (2018) investigated the association among resting irisin concentrations, regular physical activity and physical fitness in serum of healthy humans; they found that nor physical activity level, neither fitness status were related to resting irisin concentrations in healthy humans.…”

Section: Myokines and The Contracting Musclementioning

confidence: 99%

Extracellular Vesicles: Delivery Vehicles of Myokines

2019

View full text Add to dashboard Cite

Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial effects throughout the whole body. In particular, contracting skeletal muscle cells have the capacity to communicate with other organs through the release of humoral factors that play an important role in the mechanisms of adaptation to physical exercise. These muscle-derived factors, today recognized as myokines, act as endocrine and paracrine hormones. Moreover, exercise may stimulate the release of small membranous vesicles into circulation, whose composition is influenced by the same exercise. Combining the two hypotheses, these molecules related to exercise, named exer-kines, might be secreted from muscle cells inside small vesicles (nanovesicles). These could act as messengers in tissue cross talk during physical exercise. Thanks to their ability to deliver useful molecules (such as proteins and miRNA) in both physiological and pathological conditions, extracellular vesicles can be thought of as promising candidates for potential therapeutic and diagnostic applications for several diseases.

show abstract

Section: Myokines and The Contracting Musclementioning

confidence: 99%

Extracellular Vesicles: Delivery Vehicles of Myokines

2019

View full text Add to dashboard Cite

show abstract

Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

Gan

Chen

et al. 2021

Int Urol Nephrol

View full text Add to dashboard Cite

Impact of acute circuit training on irisin in younger and older overweight adults

Rioux

Brunt

Eadie

et al. 2021

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

Studies show aerobic exercise increases irisin and leads to health benefits. The impact of circuit training (CT) on irisin in overweight younger and older adults is unknown. The objectives were to determine whether, during an acute bout of CT, changes in irisin differed between overweight younger and older adults, and if irisin is associated with body composition, fitness level, or muscle strength. Inactive, overweight adults aged between 19-35 (25.9 ± 5.0; n=15) and 60-75 years old (67.7 ± 4.1; n=14) participated in this study. The primary exposure variable was an acute bout of CT (12-15 repetitions; 65-70% of 1-repetition maximum; 3 loops). The primary outcome measure was the concentration of irisin determined by ELISA before, during, and after exercise. Repeated measures analyses showed no effect of time on irisin levels during acute CT, and no interaction effect between age and time (p >0.05). No associations were observed between changes in irisin and body composition, fitness, or strength (p >0.05). In conclusion, acute CT doesn’t increase irisin in overweight individuals, nor is irisin associated with the measured outcomes. Further studies are needed to elucidate the release of irisin by different types of exercise across the lifespan. NCT03715088 NOVELTY: • Younger and older adults show a similar irisin response to an acute bout of circuit training. • Irisin response is not associated with measures of body composition, cardiorespiratory fitness, nor muscle strength.

show abstract

Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study

Cited by 3 publications

References 31 publications

Extracellular Vesicles: Delivery Vehicles of Myokines

Extracellular Vesicles: Delivery Vehicles of Myokines

Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

Impact of acute circuit training on irisin in younger and older overweight adults

Contact Info

Product

Resources

About