Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents

Abstract

Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.

Association between Selected Polymorphisms rs12086634, rs846910, rs4844880, rs3753519 of 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) and the Presence of Insulin Resistance in the Polish Population of People Living in Upper Silesia

“…The authors Gasparin et al [ 26 ] studied the association of the presence of the G allele rs846910 of the HSD11B1 gene with overweight and obesity in children and adolescents. The authors showed that the G allele (rs846910) of the HSD11B1 gene was significantly statistically associated with being overweight ( p = 0.039).…”

The correlation between APOE expression and the clinical characteristics and prognosis of patients with endometrial cancer

“…[4,5] Studies have confirmed that apolipoprotein E (APOE) gene is related to dyslipidemia and obesity. [6,7] In recent years, APOE has attracted widespread attention as an important protein related to tumorigenesis and metastasis. [8][9][10] Studies have shown that APOE is an effective biomarker for evaluating lymph node metastasis in patients with non-small cell lung cancer.…”