Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children

Gao, Liwang; Wu, Lijun; Zhang, Meixian; Zhao, Xiaoyuan; Cheng, Hong; Mi, Jie

doi:10.1590/1678-4685-gmb-2017-0107

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…No Brasil, Anghebem-Oliveira et al (2017), não encontraram associação entre o SNP rs1421085 e o diabetes gestacional. Na China, Gao et al (2018), demonstraram pela primeira vez que o SNP rs6499640 no FTO está associado ao aumento do LDL-Colesterol, colesterol total e triglicerídeos em meninas chinesas, porém não foram encontradas diferenças significativas entre este SNP e os níveis e lipídico em meninos. No Chile, Gonzalez-Rojas et al (2018), constatou que não existem diferenças antropométricas entre jovens chilenos com diferentes genótipos do polimorfismo rs17817449 da FTO.…”

Section: Resultsunclassified

A AÇÃO DOS POLIMORFISMOS DE NUCLEOTÍDEO ÚNICO (SNPs) SOBRE O GENE FTO, SUA RELEVÂNCIA E INFLUÊNCIA NA OBESIDADE: LEVANTAMENTO CIENCIOMÉTRICO

Filho

Massambani

Diegues

et al. 2021

Arq. Ciênc. Saúde Unipar

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A obesidade é caracterizada pelo aumento excessivo da gordura corporal e está ligada ao estilo de vida, ao meio ambiente e a genética do indivíduo. O equilíbrio entre ingestão e gasto energético é controlado por mecanismos neurais, hormonais, químicos e genéticos. Estudos sugerem que o gene FTO (Fat mass and obesity associated) atua como regulador primário do acúmulo de gordura corporal, quando associado a SNPs (Single Nucleotide Polymorphism) específicos, predispõe à obesidade. O propósito deste trabalho foi verificar a produção científica, analisar e catalogar os estudos de polimorfismos no gene FTO associados à obesidade e suas comorbidades. A busca por publicações entre 2009 e 2018 foi realizada na base de dados SciELO com a palavra-chave “FTO”. Foram encontrados 23 artigos originais dentro dos critérios da pesquisa que correlacionam o FTO à obesidade. O nome do autor principal, país, idioma, ano de publicação, título, objetivo, polimorfismo associado e os resultados dos estudos foram extraídos e organizados para facilitar a tabulação dos dados. Também foram pesquisados os números de citações de cada artigo, utilizando-se a plataforma Google Acadêmico. Embora o Brasil se encontre em primeiro lugar em produção científica para o gene FTO na base de dados prospectada, o número de artigos originais ainda é muito modesto. Assim, os resultados encontrados podem servir de subsídio no delineamento de novas pesquisas sobre os polimorfismos do gene FTO e as causas da obesidade.

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Section: Resultsunclassified

A AÇÃO DOS POLIMORFISMOS DE NUCLEOTÍDEO ÚNICO (SNPs) SOBRE O GENE FTO, SUA RELEVÂNCIA E INFLUÊNCIA NA OBESIDADE: LEVANTAMENTO CIENCIOMÉTRICO

Filho

Massambani

Diegues

et al. 2021

Arq. Ciênc. Saúde Unipar

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“…In a cohort of Romanian children and adolescents aged 2–17 years, Duicu et al found that the G allele carriers of the rs17817449 polymorphism had a higher average level of TG than the subjects with the TT genotype (1.12 vs. 0.39 mmol/L, p = 0.003) [ 129 ]. Gao et al investigated the association of the rs6499640 polymorphism with lipid levels in a group of Chinese children and adolescents and observed that the subjects with the GG or GA genotype had a higher average level of TG than those with the AA genotype among girls (0.94 vs. 0.75 mmol/L, p = 0.001), but not in boys [ 130 ].…”

Section: Some Genetic Polymorphisms Of Fto Increas...mentioning

confidence: 99%

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

et al. 2023

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Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphisms in intron 1, such as rs9939609 and rs9930506 polymorphisms, are significantly associated with the development of MetS in children and adolescents. Mechanistic studies reported that FTO polymorphisms lead to aberrant expressions of FTO and the adjacent genes that promote adipogenesis and appetite and reduce steatolysis, satiety, and energy expenditure in the carriers. The present review highlights the recent observations on the key FTO polymorphisms that are associated with child and adolescent MetS with an exploration of the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia in child and adolescent MetS.

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“…The adipose tissue cells are capable of synthesising and secreting biologically active substances, called adipokines [1]. They fulfil various biological functions, including the regulation of appetite and satiety, maintaining energy homeostasis, fat and carbohydrate metabolism, insulin sensitivity, regulation of vascular haemostasis, blood pressure, and inflammatory and immunological processes [2]. Omentin is a relatively recently described adipokine that appears to be associated with metabolic risk factors, but its role in the organism is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Omentin rs2274907 gene polymorphism and the risk of metabolic syndrome: a preliminary report

Suliga¹,

Kozieł²,

Cieśla³

et al. 2018

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Introduction: Omentin is a relatively recently examined adipokine that appears to be associated with metabolic risk factors and metabolic syndrome. Aim of the research: To analyse the relationship between omentin rs2274907 gene polymorphism and the risk of metabolic syndrome and its components. Material and methods: Genetic material and the clinical data of 219 individuals were analysed, including 108 with metabolic syndrome (MetS), diagnosed on the basis of International Diabetes Federation (IDF) criteria. Omentin rs2274907 mutation was detected using the PCR-RFLP method. Results: The genotype distribution showed no deviation from the Hardy-Weinberg equilibrium (χ 2 = 3.055; p = 0.080). No significant association was found between the Asp allele of omentin rs2274907 and MetS or its components, when compared to the Val allele (p = 0.198). The Val/Asp, Asp/Asp and Val/Asp + Asp/Asp genotypes also showed no association with MetS and its components when compared to Val/Val genotype (p = 0.662; p = 0.627; p = 0.938, respectively). Only a statistically insignificant tendency towards a more frequent occurrence of the Val/Asp genotype in subjects with MetS (42.60% vs. 34.24%) and more frequent occurrence of the Asp/Asp genotype in the control group (53.15% vs. 44.44%) was reported. Statistically significant correlations between omentin Val109Asp polymorphism and MetS risk and its components were not found in the model adjusted for age, sex, smoking habits or physical activity. Conclusions: The results of the conducted research did not show any significant relationship between omentin polymorphism Val109Asp and MetS risk. There were no associations of this polymorphism with any of the MetS components. It is necessary to conduct further research on a larger population. Streszczenie Wprowadzenie: Omentyna to jedna ze stosunkowo niedawno opisanych adipokin. Wydaje się, że ma ona związek z metabolicznymi czynnikami ryzyka i zespołem metabolicznym. Cel pracy: Analiza zależności pomiędzy polimorfizmem genu omentyny rs2274907 a ryzykiem wystąpienia zespołu metabolicznego (MetS) oraz jego elementów.

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Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children

Cited by 6 publications

References 23 publications

A AÇÃO DOS POLIMORFISMOS DE NUCLEOTÍDEO ÚNICO (SNPs) SOBRE O GENE FTO, SUA RELEVÂNCIA E INFLUÊNCIA NA OBESIDADE: LEVANTAMENTO CIENCIOMÉTRICO

A AÇÃO DOS POLIMORFISMOS DE NUCLEOTÍDEO ÚNICO (SNPs) SOBRE O GENE FTO, SUA RELEVÂNCIA E INFLUÊNCIA NA OBESIDADE: LEVANTAMENTO CIENCIOMÉTRICO

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Omentin rs2274907 gene polymorphism and the risk of metabolic syndrome: a preliminary report

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