Production, solubility and antioxidant activity of curcumin nanosuspension

Abstract

Curcumin is a powerful bioactive agent and natural antioxidant, but it is practically water-insoluble and has low bioavailability; a possible solution to this obstacle would be formulations of curcumin nanoparticles. Surfactants such as tween 80 can be used to stabilize low-solubility molecules preventing particle aggregation. The objectives of this study were the preparation of a suspension with curcumin nanoparticles in tween 80, the testing of pure curcumin solubility and of a simple mixture of curcumin with tween 80 and nanosuspension in water and ethanol as solvents, and finally the assessment of the antioxidant activity. We prepared the nanosuspension by injecting a curcumin solution in dichloromethane at low flow in water with tween 80 under heating and ultrasound. The analysis of particles size was conducted through dynamic light scattering; the non-degradation of curcumin was verified through thin-layer chromatography. The analyses of antioxidant activity were carried out according to the DPPH method. The method applied to reduce the particles size was efficient. Both the curcumin suspension and nanosuspension in tween 80 increased its solubility. Curcumin and the formulations presented antioxidant activity.

Evaluation of Release Kinetics and Mechanisms of Curcumin and Curcumin-β-Cyclodextrin Inclusion Complex Incorporated in Electrospun Almond Gum/PVA Nanofibers in Simulated Saliva and Simulated Gastrointestinal Conditions

“…To determine the loading efficiency of curcumin in the almond gum/PVA nanofibers, approximately 10 mg of the nanofibers were added to 5 ml of 50% ethanol aqueous solution and agitated for 24 h at room temperature to completely dissolve [22]. The absorbance of the samples was read at 425 nm after filtration through a 0.45 μm filter [23,24]. The amount of curcumin presented in the samples was calculated using calibration curves.…”

Molluscicidal Activities of Curcumin-Nisin Polylactic Acid Nanoparticle (PLA) on Adult Snail Intermediate Hosts of Schistosomes and Fasciola spp.

“…The snails were brought to the Parasitology Laboratory of the Department of Zoology, University of Ibadan for the study. Snail culture Twenty five (25) adult snails each of B. pfeifferi, L. natalensis and B. globosus were transferred separately into a culture jar (aquarium) lined with transparent polythene bags containing dechlorinated tap water. The snails were fed with blanched dried lettuce (Lactuca sativa), and CaCO 3 pellets were used as calcium supplements.…”

Filme ativo de acetato de celulose incorporado com nanosuspensão de curcumina

“…marca Vetec Cód. 749 Lote 1103476; mistura simples preparada com 22,2% de curcumina em tween 80; nanosuspensão de curcumina preparada com 22,2% de curcumina em tween 80 produzida conforme Carvalho et al [15] ; acetona P.A. 99,6% marca Neon ref.…”