Effect of multimode ultrasound assisted extraction on the yield of crude polysaccharides from Lycium Barbarum (Goji)

Muatasim, Rahma; Ma, Haile

doi:10.1590/1678-457x.14417

Cited by 17 publications

(9 citation statements)

References 34 publications

(41 reference statements)

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“…The aforementioned could explain the reason for the high yield at a dual‐frequency of 20–40 kHz. The result is supported by that of Muatasim et al (), who reported that enhanced cavitation efficiencies in dual‐frequency (20–40 kHz) resulted in a significant yield of 38.93% crude polysaccharides from Lycium barbarum .…”

Section: Resultssupporting

confidence: 76%

“…However, this technique has been associated with initiating the degradation of polysaccharides due to prolonged ultrasonic treatment (Dong et al, ). In recent times, alternative modes to mono frequency irradiation such as dual‐frequency (DFu) have emerged and reported to have a better cavitation and product yield through a simultaneous effect of low and high frequencies (Muatasim, Ma, & Yang, ).…”

Section: Introductionmentioning

confidence: 99%

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Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Chikari

Han

Wang

et al. 2020

J Food Process Engineering

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The study investigated the effect of dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and desalination on the yield, microstructure and antioxidant properties of Astragalus polysaccharides (APS). Extracts were desalinated for 10 (APS10), 20 (APS20), and 30 (APS30) minutes. A 28.40% experimental yield, well correlated to the response surface methodology predicted model was achieved. Thermodynamic parameters were non‐spontaneous, irreversible and endothermic. Moreover, ultrasound enhanced the desalination rate and did not alter the chemical structure in the APS. Fourier Transform Infrared Spectroscopy showed a similar spectrum in all the APS samples. High‐performance gel chromatography and scanning electron microscopy, respectively presented reduced molecular weights and altered microstructures in the samples. Monosaccharide analysis revealed the existence of xylose, mannose, galactose, glucose, arabinose, rhamnose, and ribose in the APS samples. Moreover, the APS20 showed strong hydroxyl and 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activities, thus showing its potency in reducing oxidative stress. Hence, this study demonstrates that coupled ultrasound and alcohol/salt ATPS is a sustainable technique, which generates high yields of simultaneously extracted products. Practical applications Astragalus root has been used as an effective complementary treatment to conventional medicine owing to its rich nutraceutical composition and its numerous health attributes. Commercialization of Astragalus supplements into functional foods and nutraceuticals requires continuous exploration of novel, low cost and reproducible methods that retain their bioactivity. In this work, a synergized and bio‐compatible dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase system was used to extract and purify Astragalus polysaccharides. Application of this technique in the nutraceutical industry reduces treatment time, lowers bulk energy consumption hence reducing energy costs. It promotes the use of low‐cost, non‐hazardous bio‐based solvents in treatment processes thus considerably reducing extraction costs and environmental degradation. Findings from this study exhibit the practicability of this technique in industrial application. It equips biotechnologists with information on improved, sustainable and safer ways of extracting and enriching the quality of nutraceutical compounds.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Chikari

Han

Wang

et al. 2020

J Food Process Engineering

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“…Some studies have recently shown that a multi‐frequency US method had better treatment efficiency than single‐frequency US method, such as in the degree of hydrolysis of casein, the extraction of biomacromolecules, and the structure modification of gluten protein (Muatasim et al., 2018; B. Xu et al., 2020; H. Zhang, Chen, et al., 2020). Phyllis Naa Yarley et al.…”

Section: Ultrasoundmentioning

confidence: 99%

“…The authors demonstrated that ultrasonic-treated CPs exhibited better emulsifying properties in an oil-in-water emulsion system but weaker rheological and gelling properties than the original CPs, mainly due to their molecular weight and chain conformations than the others (e.g., galacturonic acid content, DM, and amount of neutral sugar side chains). Some studies have recently shown that a multifrequency US method had better treatment efficiency than single-frequency US method, such as in the degree of hydrolysis of casein, the extraction of biomacromolecules, and the structure modification of gluten protein (Muatasim et al, 2018;B. Xu et al, 2020;…”

Section: Us Modification Of Polysaccharidesmentioning

confidence: 99%

Application of nonthermal processing technologies in extracting and modifying polysaccharides: A critical review

Zhang

et al. 2021

Comp Rev Food Sci Food Safe

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Polysaccharides are natural polymer compounds widely distributed in plants, animals, and microorganisms, most of which have a broad spectrum of biological activities to promote human health. They could also be used as texture modifiers in food industry due to their excellent rheological and mechanical properties. Many researchers have shown that nonthermal processing technologies have numerous advantages, such as high extraction efficiency, short extraction time, and environmental friendliness, in the extraction of polysaccharides compared with the traditional extraction methods. Moreover, nonthermal technologies could effectively change the physicochemical properties and structural characteristics of polysaccharides to improve their biological activities or processing properties. Therefore, a comprehensive summary about the extraction and modification of polysaccharides by nonthermal technologies, including ultrasound, high hydrostatic pressure, pulsed electric fields, and cold plasma, was provided in this review. In particular, the underlying mechanisms, processing operations, and current application status of these technologies were discussed. In addition, the applications of combining nonthermal techniques with other technological methods in polysaccharide extraction and modification were briefly introduced.

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“…LBP can promote the immune function of T, B, CTL, NK and macrophages, promote the production of cytokines such as IL-2, IL-3 and TNFβ, enhance the immune function of tumor-bearing, chemotherapy and radiation-damaged mice, and regulate neuroendocrine immune regulatory network (Muatasim et al, 2018). However, whether LBP has a protective effect in T2D-induced neuronal axonal transport disorder, or whether it can improve the impaired axonal transport, has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lycium Barbarum Polysaccharides (LBP) on the cognitive function of rats with type 2 diabetic encephalopathy

Zhao

et al. 2022

Food Sci. Technol

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This study aims to explore the molecular mechanism of neuronal axonal lesions caused by high glucose, and to investigate the protective effect of Lycium barbarum polysaccharide (LBP) on neuronal axon damage with in vitro models. A rat model of type II diabetic encephalopathy was established, and the rats were treated with LBP for 10 weeks. Morris water maze experiment was used to detect spatial learning and memory ability. Neuronal axon lesions were measured by in vivo neuron tracing experiment. Immunohistochemistry and Western-blot technology were employed to detect protein localization and expression. Combined with in vitro primary neuron culture, total internal reflection fluorescence microscopy was used to detect the effects of high glucose and LBP on neuronal axon transport. PI3K inhibitors LY294002 and an activator of insulin signaling pathway were used to investigate the possible molecular mechanism. In vivo and in vitro experiments showed that in the hippocampus tissue of STZ-induced type II diabetic encephalopathy model rats, neuronal axons were damaged, accompanied by hyperphosphorylation of Tau protein, which subsequently resulted in axonal transport damage and cognition dysfunction. LBP significantly reduced peripheral blood glucose and serum insulin levels in type II diabetic encephalopathy model rats, thereby alleviating peripheral insulin resistance. At the same time, LBP can significantly improve the learning and memory impairment and brain neuron axon pathology in model rats. LY294002 treatment can effectively block the PI3K/Akt signaling pathway. The phosphorylation level of Tau protein in the LY294002+ LBP treatment group is higher than that of the LBP intervention group, while the insulin treatment can effectively reverse the blocking effect of LY294002 on LBPs. LBP can reduce the phosphorylation level of Tau protein by up-regulating the PI3K/Akt/GSK3β signaling pathway, with a protective effect on neuronal axon damage, thereby improving the cognitive function performance of type II diabetic encephalopathy model rats.

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Effect of multimode ultrasound assisted extraction on the yield of crude polysaccharides from Lycium Barbarum (Goji)

Cited by 17 publications

References 34 publications

Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Application of nonthermal processing technologies in extracting and modifying polysaccharides: A critical review

Effect of Lycium Barbarum Polysaccharides (LBP) on the cognitive function of rats with type 2 diabetic encephalopathy

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