Protective Role of Ferulic Acid on Testis-Histoarchitecture and Oxidative Damages Induced by Dimethoate in Rats

Coexposure to exogenous neurotoxins, such as fluoride (F−) and dimethoate (DM), is a serious public health concern. In the current study, Wistar rats were exposed to DM (1/10th LD50) and F− (4.5 ppm) in drinking water individually as well as in combination continuously for 28 days and the effectiveness of ginger and quercetin was assessed in combating the oxidative stress-mediated combined toxic effects on blood and brain. Significant (p<0.05) reductions were observed in the levels of total antioxidant status (TAS), glutathione peroxidase (GPx), blood glutathione (GSH), activities of catalase (CAT), total thiols (TTH), superoxide dismutase (SOD), aryl esterase (AE), and acetylcholinesterase (AChE) whereas significant elevations (p<0.05) in malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were recorded in blood and brain of coexposed rats. Administration of ginger and quercetin significantly (p<0.05) ameliorated the combined F- and DM-induced hematotoxicity as well as neurotoxicity as indicated by the levels of markers of oxidative injury in brain and blood in coexposed rats, which showed significant (p<0.05) improvement. Moreover, pathological changes, such as neurodegeneration, perivascular edema, and gliosis, observed after combined F− and DM toxicity in the brain (cerebrum and cerebellum) were markedly reduced after ginger supplementation.

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Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Apaydın

Kalender

Baş

et al. 2023

Preprint

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Fenitrothion (FNT) is a known environmental contaminant used in public health and agriculture. Gallic acid (GA) is a phenolic compound found in numerous plants. This study analyzed the hepatotoxic and nephrotoxic effects of FNT and to evaluate the possible protective effect of gallic acid. FNT (1/25 LD50, 32 mg/kg body weight/day), and gallic acid (50 mg/kg body weight/day) were administrated to male rats by gavage for 28 days. In the present study, the renal (blood urea nitrogen, creatinine and uric acid levels) and liver (albumin, total protein, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, lactate dehydrogenase) function markers in the blood, acetylcholinesterase activities, antioxidant enzyme activities and malondialdehyde level as markers of oxidative stress, and histopathological changes were researched in liver and kidney tissues. Additionally, while superoxide dismutase, catalase, glutathione-S-transferase and glutathione peroxidase activities were decreased in the liver and kidney tissue of rats treated with fenitrothion, malondialdehyde level was significantly increased. Histopathological analyses showed many injuries occurred in the renal and hepatic tissue of fenitrothion-treated animals. Also, the supplementation of gallic acid with fenitrothion significantly improved fenitrothion-induced alterations in renal and liver function markers, antioxidant enzyme activities, acetylcholinesterase activities malondialdehyde levels, and histological features of tissues.

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Protective Role of Ferulic Acid on Testis-Histoarchitecture and Oxidative Damages Induced by Dimethoate in Rats

Cited by 3 publications

References 39 publications

The potential ameliorative impacts of rare earth element cerium in dimethoate induced toxicity in freshwater mussel Dreissena polymorpha

The potential ameliorative impacts of rare earth element cerium in dimethoate induced toxicity in freshwater mussel Dreissena polymorpha

Ameliorative Potential of Ginger (Zingiber officinale) following Repeated Coexposure with Fluoride and Dimethoate in Blood and Brain of Wistar Rats

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

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