Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review

Abstract

To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99m Tc-eluate and 99m Tc-radiopharmaceuticals, as well as to assess doses calibrator reliability for routine purposes in hospital radiopharmacies. RCP was determined by different systems and radioactivity was quantified by TLC-scanner, doses calibrator and gamma-counter. Suitable and optimized systems were presented for RCP analyses. No significant differences were observed between radioactivity counting devices and, thus, doses calibrator showed reliability for RCP determination in hospital radiopharmacies. HIGHLIGHTS • ANVISA recommends the performance of quality control tests of 99m Tc-radiophamaceuticals. • Requirement of hospital radiopharmacy routine adaptation to ANVISA's recommendation. • Requirement of the radiochemical purity (RCP) methods validation. • Dose calibrator is reliable for RCP analysis in hospital radiopharmacies. •. Miranda, A.C.C.; et al.

Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

“…For instance, free pertechnetate has been found in thyroid upon lung scintigraphy due to unstable radiolabelled compound or complex [42]. Although such extrapulmonary distribution will not harm the organs, free radionuclides in significant amounts can disturb lung scintigraphy [43,44]. Therefore, standard quality control for radiopharmaceuticals, e.g., radiochemical purity, should also be performed in the lung scintigraphy.…”