Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

Munir, Misbakhul; Setiawan, Herlan; Awaludin, R.; Kett, Vicky L.

doi:10.1007/s40336-022-00527-3

Cited by 2 publications

(1 citation statement)

References 127 publications

(191 reference statements)

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“…Moreover, the hardware to scan have also been under constant upgrade in imaging modality’s functional characteristics and image enhancement tools, together with the computographics and the requisite software for signal enhancements, noise suppression, and better vision developments [ 118 ] of the region of interest in imaging. Magnetic particle imaging (MPI) for angiography and chronic kidney malfunctions [ 119 ], use of amine-functionalized MNPs [ 120 ], and nebulized MNPs use in pulmonary tracing [ 121 ], in essence, are dependent upon the nano-scale tracer materials’ properties optimized to detail the affected organs’ disparity against normal cells. Iron oxide nano-scale tracers with a multi-folds signal-to-noise ratio with enhanced spatial resolution have also been developed.…”

Section: Spions-inspired Magnetic Spectroscopy: Development Of a Medi...mentioning

confidence: 99%

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

et al. 2022

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Considerable efforts have been directed towards development of nano-structured carriers to overcome the limitations of anticancer drug, doxorubicin’s, delivery to various cancer sites. The drug’s severe toxicity to cardio and hepatic systems, low therapeutic outcomes, inappropriate dose–demands, metastatic and general resistance, together with non-selectivity of the drug have led to the development of superparamagnetic iron oxide nanoparticles (SPIONs)-based drug delivery modules. Nano-scale polymeric co-encapsulation of the drug, doxorubicin, with SPIONs, the SPIONs surface end-groups’ cappings with small molecular entities, as well as structural modifications of the SPIONs’ surface-located functional end-groups, to attach the doxorubicin, have been achieved through chemical bonding by conjugation and cross-linking of natural and synthetic polymers, attachments of SPIONs made directly to the non-polymeric entities, and attachments made through mediation of molecular-spacer as well as non-spacer mediated attachments of several types of chemical entities, together with the physico-chemical bondings of the moieties, e.g., peptides, proteins, antibodies, antigens, aptamers, glycoproteins, and enzymes, etc. to the SPIONs which are capable of targeting multiple kinds of cancerous sites, have provided stable and functional SPIONs–based nano-carriers suitable for the systemic, and in vitro deliveries, together with being suitable for other biomedical/biotechnical applications. Together with the SPIONs inherent properties, and ability to respond to magnetic resonance, fluorescence-directed, dual-module, and molecular-level tumor imaging; as well as multi-modular cancer cell targeting; magnetic-field-inducible drug-elution capacity, and the SPIONs’ magnetometry-led feasibility to reach cancer action sites have made sensing, imaging, and drug and other payloads deliveries to cancerous sites for cancer treatment a viable option. Innovations in the preparation of SPIONs-based delivery modules, as biocompatible carriers; development of delivery route modalities; approaches to enhancing their drug delivery-cum-bioavailability have explicitly established the SPIONs’ versatility for oncological theranostics and imaging. The current review outlines the development of various SPIONs-based nano-carriers for targeted doxorubicin delivery to different cancer sites through multiple methods, modalities, and materials, wherein high-potential nano-structured platforms have been conceptualized, developed, and tested for, both, in vivo and in vitro conditions. The current state of the knowledge in this arena have provided definite dose-control, site-specificity, stability, transport feasibility, and effective onsite drug de-loading, however, with certain limitations, and these shortcomings have opened the field for further advancements by identifying the bottlenecks, suggestive and plausible remediation, as well as more clear directions for future development.

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Section: Spions-inspired Magnetic Spectroscopy: Development Of a Medi...mentioning

confidence: 99%

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

et al. 2022

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Iodine-131 radiolabeled polyvinylchloride: A potential radiotracer for micro and nanoplastics bioaccumulation and biodistribution study in organisms

Munir¹,

Sholikhah

Lestari³

et al. 2023

Marine Pollution Bulletin

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Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

Cited by 2 publications

References 127 publications

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

Iodine-131 radiolabeled polyvinylchloride: A potential radiotracer for micro and nanoplastics bioaccumulation and biodistribution study in organisms

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